Apigenin‐5‐methyläther, ein neues Flavon aus Thevetia peruviana

Voigtländer, H. W.; Balsam, G.

doi:10.1002/ardp.19703031002

Cited by 10 publications

(3 citation statements)

References 8 publications

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“…Both the plants have potent molluscicidal and anticholinesterase activity against harmful snails and slugs (Panigrahi and Raut, 1994;Singh et al, 2000Singh et al, , 2004bSingh et al, , 2009Singh and Singh, 2003a). The toxicological actions of Thevetia peruviana may be due to the presence of apigenin-5-methyl ether (fl avonoid) and triterpenoid glycosides (Voigtlander and Balsam, 1970) while a number of alkaloids (pseudo-akuammigine in addition to betulin, ursolic acid and β-sitosterol), steroids and triterpenoids are present in Alstonia scholaris (Banerji and Banerji, 1977).…”

Section: Plant Origin Molluscicidementioning

confidence: 99%

Molluscicides from some common medicinal plants of eastern Uttar Pradesh, India

Singh¹,

Yadav²,

Singh

2009

J of Applied Toxicology

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Many aquatic snails act as intermediate hosts for the larvae of trematodes, Fasciola hepatica and Fasciola gigantica, which cause the diseases fascioliasis and schistosomiasis. The WHO has tested several thousands of synthetic compounds for the control of the snail host. Although effective, these molluscicides have so far not proved themselves to be entirely satisfactory. With a growing awareness of environmental pollution, efforts are being made to discover molluscicidal products of plant origin. Being products of biosynthesis, these are potentially biodegradable in nature. Several groups of compounds present in various plants have been found to be toxic to target organisms at acceptable doses ranging from <1 to 100 ppm. Common medicinal plants, i.e. Thevetia peruviana, Alstonia scholaris (Family; Apocynaceae), Euphorbia pulcherima and Euphorbia hirta (Family; Euphorbiaceae), have potent molluscicidal activity against freshwater snails. The toxicological actions of Thevetia peruviana may be due to the presence of apigenin-5-methyl ether (flavonoid) and triterpenoid glycosides, while a number of alkaloids (pseudo-akuammigine in addition to betulin, ursolic acid and beta-sitosterol), steroids and triterpenoids are present in Alstonia scholaris and the diterpenoids, pulcherrol, beta-sitosterol, hentriacontane, ellagic acid and beta-amyrin are present in Euphorbia hirta and in Euphorbia pulcherima. Although, at present very little literature is available on the control of vector snails through plant origin pesticides, an attempt has been made in this review to assemble all the known information on molluscicidal properties of common medicinal plants of eastern Uttar Pradesh, India, which might be useful for the control of harmful snails.

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Section: Plant Origin Molluscicidementioning

confidence: 99%

Molluscicides from some common medicinal plants of eastern Uttar Pradesh, India

Singh¹,

Yadav²,

Singh

2009

J of Applied Toxicology

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“…A downfield quaternary carbon (d C 120.1) of ketohexose C-2Љ should be linked to the C-2 oxygen-atom due to the absence of a free 2-OH in the 3) The NOESY spectrum (Fig. 2) showed cross peaks between protons at d 6.71 were due to the presence of protons at C-6, C-8 and C-3 in rings A and C of a vertiaflavone, respectively. Furthermore, two singlets at d H 3.90 (3H, s) and 10.26 (1H, s) were respectively assigned to protons of the methoxy group bonding to C-5 and the hydroxyl group bonding to C-4Ј of a vertiaflavone.…”

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confidence: 99%

Flavonoid and a Rare Benzophenone Glycoside from the Leaves of Aquilaria sinensis

Jing-Jing

Liu

et al. 2009

CHEMICAL & PHARMACEUTICAL BULLETIN

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“…Esterified, hydroxylated and glycosylated flavans and flavanols, such as apigenin-5-methylether [41], glycosylated dimethoxyflavanones [42], sinapoyl and feruloyl esters of kaempferol and quercetin [10] have been identified in T. peruviana plants. These compounds are antioxidants [43] and some of them retain inhibitory activity of reverse transcriptase and integrase enzymes of HIV-1 [10].…”

Section: Discussionmentioning

confidence: 99%

Phytochemical Screening of Callus and Cell Suspensions Cultures of Thevetia peruviana

Meza

Arias

Cuaspud

et al. 2020

Braz. arch. biol. technol.

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Thevetia peruviana is an ornamental shrub grown-up in many tropical region of the world. This plant produces secondary metabolites with biological properties of interest for the pharmaceutical industry. The objective was to determine the secondary metabolites profile of callus and cell suspension cultures of T. peruviana and compare them with those from explant (fruit pulp). Extracts in 50% aqueous ethanol and ethyl acetate were prepared. The phytochemical analysis was performed using standard chemical tests and thin layer chromatography. In addition, total phenolic and flavonoids compounds (TPC and TFC), total cardiac glycosides (TCG) and total antioxidant activity (TAA) was determined during the cell suspension growth. Phenolic chemical profile was also analyzed by high performance liquid chromatography (HPLC). Common metabolites (alkaloids, amino acids, antioxidants, cardiac glycosides, leucoanthocyanidins, flavonoids, phenols, sugars and triterpenes) were detected in all samples. The maximum production of extracellular TCG, TPC, TFC and TAA in cells suspensions were at 6-12 days; in contrast, intracellular content was relatively constant during the exponential grown phase (0 to 12-days). HPLC analysis detected one compound with retention time at 11.6 min; this compound was tentatively identified as dihydroquercetin, a flavonoid with anti-cancer properties. These results provide evidence on the utility of the in vitro cell cultures of T. peruviana for valuable pharmaceutical compounds production. HIGHLIGHTS Callus and cell suspensions of T. peruviana have similar phytochemical profile to in vivo plant. Cell culture of T. peruviana is a reliable platform for high-value metabolites production. Cardiac glycosides and phenolic are the most valuable metabolites detected in plant cell cultures  Dihydroquercetin production in a free and conjugated form in cell cultures is highlighted 2 Mendoza, D.; et al.

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Apigenin‐5‐methyläther, ein neues Flavon aus Thevetia peruviana

Abstract: Aus Samen von Thevetia peruviana wurde ein Flavon isoliert, bei dem es sich um den bisher nicht bekannten Apigenin‐5‐methyläther handelt. Dieses „Thevetiaflavon”︁ ist in der Droge nicht mit Zuckern verknüpft, sondern liegt frei vor.

Cited by 10 publications

References 8 publications

Molluscicides from some common medicinal plants of eastern Uttar Pradesh, India

Molluscicides from some common medicinal plants of eastern Uttar Pradesh, India

Flavonoid and a Rare Benzophenone Glycoside from the Leaves of Aquilaria sinensis

Phytochemical Screening of Callus and Cell Suspensions Cultures of Thevetia peruviana

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