Aortic glycosaminoglycans in avitaminosis

Sharaev, P. N.; Bogdanov, N. G.

doi:10.1007/bf00804779

Cited by 3 publications

(1 citation statement)

References 3 publications

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“…Деструкцію сполучної тканини оцінювали за вмістом у гомогенаті тонкої кишки мономерів, що утворюються при колагенолізі та деполімеризації протеогліканів і сіалоглікопротеїнів, а саме вільного оксипроліну [11], гексуронових кислот [12] та N-ацетилнейрамінової кислоти [13] У хибнооперованих тварин ці показники суттєво не змінювалися, проте моделювання хірургічної травми шляхом виконання лапаротомії супроводжувалося зростанням вмісту вільного оксипроліну на 15.3% (Р<0.01), гексуронових кислот на 13…”

Section: матеріал та методи дослідженняunclassified

Markers of Connective Tissue Degradation in the Small Intestine of Rats Undergoing Surgical Trauma Replicated Under Experimental Post-Traumatic Stress Disorder

Ryabushko,

Kostenko

2023

Act. Probl. of the Modern Med.

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The objective of this experiment is to study the indices of the depolymerisation of biopolymers in the small intestine connective tissue of rats undergoing surgical trauma replicated under post-traumatic stress disorder. The study was carried out on 42 white rats. The findings obtained have shown that the experimental modelling of posttraumatic stress disorder (single prolonged stress) significantly elevates the concentration of free hydroxyproline (by 44.9%, P<0. 001), hexuronic acids (by 47.0%, P<0.001), and N-acetylneuraminic acid (by 46.2%, P<0.001), indicating depolymerisation of the extracellular matrix components, collagen, proteoglycans, and sialoglycoproteins, in this organ. On the 7th day after laparotomy performed under the experimental model of posttraumatic stress disorder, the content of free hydroxyproline, hexuronic acids, and N-acetylneuraminic acid in the small intestine homogenate significantly exceeded the respective values obtained after the separate laparotomy and "sham" surgical operation performed under simulated single prolonged stress.

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Section: матеріал та методи дослідженняunclassified

Markers of Connective Tissue Degradation in the Small Intestine of Rats Undergoing Surgical Trauma Replicated Under Experimental Post-Traumatic Stress Disorder

Ryabushko,

Kostenko

2023

Act. Probl. of the Modern Med.

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Post-translational carboxylation of preprothrombin

Johnson¹

1981

The Biological Effects of Glutamic Acid and Its Derivatives

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Post-translational carboxylation of preprothrombin

Johnson

1981

Mol Cell Biochem

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In summary, in this review on the function of vitamin K in post-translational modification of precursor proteins by carboxylation of certain glutamyl residues, I have tried to cover in particular the recent work on the reaction, the enzymes involved and the mechanisms being considered. In doing this I have also considered vitamin K, its discovery, its functional form and the possible relation of its metabolism to the carboxylation reaction. Equally the various vitamin K-dependent gla-containing proteins currently known have been described. The carboxylation of synthetic small molecule exogenous substrates and the synthesis and metabolism of the products of carboxylation are of great help in studying the reaction. Structural specificity of vitamin K analogs in vivo and in vitro has been compared and the use of various antagonists in vivo and in vitro considered in attempts to gain an understanding of the overall reaction. The reactions subsequent to carboxylation, e.g., the activation of prothrombin to thrombin via serine proteases and the related activation of the other vitamin K-dependent proteins have not been considered in this review. The review has not covered prothrombin or other vitamin K-dependent protein isolation, nor the determination of these proteins. As the vitamin K-dependent protein carboxylation story has developed over the past six years, a number of reviews have been written which help in keeping up with the various aspects of the field as it has expanded. These reviews refer to many of the papers I have had to eliminate due to space limitations. They are referenced as 469-489. The review is in no sense comprehensive and many papers have been missed or only mentioned. I have tried to concentrate on the more recent work and, thus, much of the very fine work of the 1940's on vitamin K chemistry is hardly mentioned. Some redundancy has been built into the organization of the review so that a reader can obtain a reasonable view of any one section without having to search the whole review for all possible relevant information on any particular part of the field.

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Aortic glycosaminoglycans in avitaminosis

Cited by 3 publications

References 3 publications

Markers of Connective Tissue Degradation in the Small Intestine of Rats Undergoing Surgical Trauma Replicated Under Experimental Post-Traumatic Stress Disorder

Markers of Connective Tissue Degradation in the Small Intestine of Rats Undergoing Surgical Trauma Replicated Under Experimental Post-Traumatic Stress Disorder

Post-translational carboxylation of preprothrombin

Post-translational carboxylation of preprothrombin

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