Anxiolytic-like, stimulant and neuroprotective effects of Ilex paraguariensis extracts in mice

Santos, E.; Bicca, Maíra A.; Blum-Silva, Carlos H.; Costa, Ana Paula; Santos, Alessandra Antunes dos; Schenkel, Eloir Paulo; Farina, Marcelo; Reginatto, Flávio Henrique; Lima, Thereza Christina Monteiro de

doi:10.1016/j.neuroscience.2015.02.004

Cited by 35 publications

(16 citation statements)

References 32 publications

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“…In addition, some studies have reported yerba mate to possess neuroprotective properties, such as antidepressant-like (Ludka et al 2016), anxiolytic and stimulant (Santos et al 2015) effects, as well as attenuation of dyskinesia and memory dysfunction (Colpo et al 2007;Costa et al 2015), and reduction of the frequency of pentylenetetrazol-induced seizures (Branco Cdos et al 2013). These effects emphasize the therapeutic potential of this natural product.…”

Section: R a F Tmentioning

confidence: 96%

“…Regarding crude extracts, Ilex paraguariensis extracts have demonstrated the ability to prevent memory deficits in rats (Colpo et al 2007;Santos et al 2015), and a capacity to reduce the frequency of seizures, minimizing the neuronal damage associated with their periodic occurrence (Branco Cdos et al 2013). Moreover, Cittadini et al (2015) reported that this plant could be a source of chemopreventive agents to combat oxidative stress-related neurodegenerative pathologies because of its redox effects in brain regions.…”

Section: Introductionmentioning

confidence: 99%

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Compounds from Ilex paraguariensis extracts have antioxidant effects in the brains of rats subjected to chronic immobilization stress

Colpo

Lima

Maya-López

et al. 2017

Appl. Physiol. Nutr. Metab.

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Immobilization induces oxidative damage to the brain. Ilex paraguariensis extracts (Mate) and their major natural compound, chlorogenic acid (CGA), exert protective effects against reactive oxygen species formation. Here, the effects of Mate and CGA on oxidative damage induced by chronic immobilization stress (CIS) in the cortex, hippocampus, and striatum were investigated. For CIS, animals were immobilized for 6 h every day for 21 consecutive days. Rats received Mate or CGA by intragastric gavage 30 min before every restraint session. Endpoints of oxidative stress (levels of lipid peroxidation, protein carbonylation, and reduced (GSH) and oxidized (GSSG) forms of glutathione) were evaluated following CIS. While CIS increased oxidized lipid and carbonyl levels in all brain regions, CGA (and Mate to a lesser extent) attenuated lipid and protein oxidation as compared with control groups. GSH/GSSG balance showed a tendency to increase in all regions in response to stress and antioxidants. Taken together, our results support a protective role of dietary antioxidants against the neuronal consequences of stress.

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Section: R a F Tmentioning

confidence: 96%

Section: Introductionmentioning

confidence: 99%

Compounds from Ilex paraguariensis extracts have antioxidant effects in the brains of rats subjected to chronic immobilization stress

Colpo

Lima

Maya-López

et al. 2017

Appl. Physiol. Nutr. Metab.

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“…Numerous active components have been identified in Yerba Mate. Some of them are antioxidant (Boaventura et al, ; Mateos, Baeza, Sarriá, & Bravo, ), anti‐obesity (Alkhatib, ; Arçari, Santos, Gambero, & Ribeiro, ), antidiabetic (Kang et al, ), neuroprotective (Santos et al, ), vasodilatory (Pontilho et al, ), anti‐mutagenic (Bracesco et al, ), anti‐glycation effects, increasing of energy, antimicrobial (Yuan & Yuk, ), and anti‐inflammatory (Luz et al, ).…”

Section: Introductionmentioning

confidence: 99%

Development of a preliminary sensory lexicon for mate tea

Godoy

Chambers

Yang

2020

Journal of Sensory Studies

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A Lexicon was developed for yerba mate tea including attributes, definitions, and references to describe the color, aroma, and flavor. A highly trained panel generated 39 attributes and evaluated 18 samples of tea. Some attributes such as smoky, woody, straw-like, ashy, astringent, bitter, sweet aromatics, musty dusty, and dark green were present in most of the samples. Other characteristics such as green, floral, spice brown, and petroleum-like appeared in less than 50% of the samples. The sensory profile of mate tea was complex but differed for various teas. This terminology can be useful for manufacturers, producers, and consumers and helpful for the standardization of mate tea. Practical applicationThe development of a sensory lexicon for mate tea can be helpful for the entire mate tea chain from grower to producer to consumer. Such a lexicon aids researcher in breeding programs for Yerba Mate, can help crop managers producing mate tea with the desired characteristics; assists manufacturers in differentiating products, categorizing and selecting of raw material, optimizing processes and developing new products;and can ensure consumers they are getting a consisted, expected product. Such data are critical for use in sensory studies where descriptive data are related to consumer preferences and for conducting studies in different, labs, regions, and countries.

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“…Additionally, independent of the metabolic effects, a neuro-modulatory effect through synergism between the phenolics and xanthines could drive central nervous system stimulation (10,11). YM has additionally been reported to have analgesic and anxiolytic effects in rodents (14), which could also be a factor resulting in positive performance outcomes.…”

Section: Introductionmentioning

confidence: 99%