Compounds from Ilex paraguariensis extracts have antioxidant effects in the brains of rats subjected to chronic immobilization stress

Abstract

Immobilization induces oxidative damage to the brain. Ilex paraguariensis extracts (Mate) and their major natural compound, chlorogenic acid (CGA), exert protective effects against reactive oxygen species formation. Here, the effects of Mate and CGA on oxidative damage induced by chronic immobilization stress (CIS) in the cortex, hippocampus, and striatum were investigated. For CIS, animals were immobilized for 6 h every day for 21 consecutive days. Rats received Mate or CGA by intragastric gavage 30 min before every restraint session. Endpoints of oxidative stress (levels of lipid peroxidation, protein carbonylation, and reduced (GSH) and oxidized (GSSG) forms of glutathione) were evaluated following CIS. While CIS increased oxidized lipid and carbonyl levels in all brain regions, CGA (and Mate to a lesser extent) attenuated lipid and protein oxidation as compared with control groups. GSH/GSSG balance showed a tendency to increase in all regions in response to stress and antioxidants. Taken together, our results support a protective role of dietary antioxidants against the neuronal consequences of stress.

Effects of bioavailable phenolic compounds from Ilex paraguariensis on the brain of mice with lung adenocarcinoma

“…Although unpublished data of our group suggest variable redox effects in different organs of LAC‐1‐bearing mice, the current work did not show redox involvement of the identified bioavailable compounds as lipoperoxide‐modulating agents. The antioxidant capacity of IP has demonstrated to be neuroprotective under different conditions (Colpo et al, ; De Lima et al, ). In the case of lung cancer, additional deleterious responses are triggered in the brain and its cells, such as inflammation (Cittadini et al, ; Cittadini et al, ), which was controlled here.…”

Chimarrão consumption and prognostic factors in breast cancer: Correlation with antioxidants and blood caffeine levels

“…However, the consumption of Ilex paraguariensis by healthy individuals leads to increased GSH levels when compared with baseline values prior to its consumption (Boaventura et al, 2015). Yerba mate contains several bioactive compounds with redox‐modulating properties that act against ROS (Colpo et al, 2017). The same effect on GSH levels been observed in patients presenting with chronic diseases, such as diabetes mellitus Type II (Boaventura et al, 2013), dyslipidemia, and cardiovascular disease (Boaventura et al, 2012).…”

A Case–Control Study of the Effects of Chimarrão (Ilex paraguariensis) and Coffee on Parkinson's Disease

“…Mate was previously associated with lower PD risk in Argentina, and caffeine was considered the probable mediator of this effect (7). Previous studies have demonstrated a high content of antioxidants and substances with iron chelation properties in IP, which could elicit a potential protective effect on PD (8,9). In a recent study by Bernardi et al (10), they demonstrated that IP may have a strong neuroprotective activity on dopaminergic neurons, preventing their death with a dosedependent effect (10).…”