Anxiolytic effects of Lavandula angustifolia odour on the Mongolian gerbil elevated plus maze

Bradley, Belinda Fay; Starkey, Nicola J.; Brown, Stephen L.; Lea, Robert

doi:10.1016/j.jep.2006.12.021

Cited by 110 publications

(78 citation statements)

References 40 publications

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“…Inhalation of the vapour of the lavender essential oil and its main constituent, linalool, has shown sedative effects in both human and animal studies [37]. Other pharmacological effects of this oil, including anticonvulsive [38] anxiolytic [39], antidepressant [40], and anticonflict effects [41], have also been reported. On the other hand, lavender is also used as a tea infusion (i.e., aqueous extracts) to treat restlessness, insomnia, and nervous disorders of the stomach and intestines [42].…”

Section: Lavandula Angustifoliamentioning

confidence: 80%

Phyto-Pharmacological Effect of Nine Medicinal Plants as a Traditional Treatment on Depression

Bakhshaei¹

2017

J Appl Pharm

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Anxiety, stress and depression are characterized by widespread and highly comorbid psychiatric conditions in the world that are defined as a negative emotional experience and are associated with biochemical, cognitive, behavioural and psychological changes. Herbal medicine has been widely used among suffering and anxiety disorders since ancient times. The modern pharmacological therapy is costly and associated with multiple side effects resulting in patient non-compliance. Thus there is a need to explore alternative therapies particularly from herbal sources as these are cost effective and possess minimal side effects. This review investigates the available studies on the pharmacological effects of some medicinal plants on depression. The studied plants include: Melissa officinalis, Lavandula angustifolia, Cinnamomum zeylanicum, Viola odorata, Echium amoneum, Valeriana officinalis, Aloysia triphylla, Citrus aurantium and Salix aegyptica. The present article is a comprehensive review of the pharmacological properties, especially anti-depressants, anti-anxiety of nine medicinal plants that could be useful for clinical studies to produce an herbal product which use treat depression.

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Section: Lavandula Angustifoliamentioning

confidence: 80%

Phyto-Pharmacological Effect of Nine Medicinal Plants as a Traditional Treatment on Depression

Bakhshaei¹

2017

J Appl Pharm

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“…Due to the constant need to identify new sources of treatments for anxiety disorders, aromatherapy has grown in importance as an area in alternative medicine with proven high efficacy in reducing stress and improving mood disorders and vital signs (Bradley et al, 2007;Steflitsch & Steflitsch, 2008;Boehm et al, 2012).…”

Section: Discussionmentioning

confidence: 99%

“…When inhaled, through the nose and olfactory cortex, the odors of EOs seem to exert a direct effect on the limbic system where anxiety and emotions are often processed (Bradley et al, 2007). This gives inhalation an advantage over other routes of administration such as, for example, the oral route, and eliminates the possibility of any chemical changes to the oil as it passes through the digestive system, mainly regarding to the first-pass effect (Bradley et al, 2007).…”

Section: Discussionmentioning

confidence: 99%

Anxiolytic-like effect of Citrus limon (L.) Burm f. essential oil inhalation on mice

Viana

Cardoso

Silva

et al. 2016

Rev. bras. plantas med.

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Experimental in vivo study aimed to characterize the anxiolytic-like effect of the Citrus limon fruit peel's essential oil (CLEO) in animal models of anxiety, besides evaluating the viability J774.A1 cells in vitro through the MTT reduction method at the concentrations of 10 and 100 µg/mL. The anxiolytic behavior was evaluated in Swiss mice (n = 8) using the methodology of Elevated Plus-Maze (EPM) and Open-Field (OF). CLEO was tested by inhalation at the doses of 100, 200, and 400 µL, and as control, animals were subjected to inhalation of the vehicle (saline solution 0.9% + Tween80®) and intraperitoneal administration of diazepam (1.5 mg/kg). In the cell viability assay, it was observed that none of the concentrations showed cytotoxicity. OF test showed significant anxiolytic activity at all tested doses of OECL, compared to the control group, without changing the motor performance of the animals. Corroborating OF data, the EPM test confirmed anxiolytic activity in at least two doses of the tested oil (200 and 400 µL), justified by the number of entries and increase in the percentage of time in the open arms. The data analysis of this study evidenced that inhalation of OECL was able to induce an anxiolytic behavior in mice; however, further studies are required to ensure its safe use by the population. .A1 através do método de redução do MTT nas concentrações de 10 e 100 µg/mL. O comportamento ansiolítico foi avaliado em camundongos Swiss (n = 8), utilizando a metodologia do Labirinto em Cruz Elevado (LCE) e do Campo Aberto (CA). O OECL foi testado por inalação nas doses de 100, 200 e 400 µL, e como controle, os grupos foram submetidos à inalação do veículo (Solução fisiológica 0,9% + Tween80®) e administração intraperitoneal de diazepam (1,5 mg/kg). No ensaio de viabilidade celular, observou-se que nenhuma das concentrações apresentou citotoxicidade. O teste de CA demonstrou atividade ansiolítica significativa em todas as doses testadas do OECL, comparada ao grupo controle, sem alterar a performance motora dos animais. Corroborando os dados do CA, o teste do LCE confirmou a atividade ansiolítica em pelo menos duas das doses do óleo testadas (200 e 400 µL), justificada pelo número de entradas e aumento na percentagem de tempo nos braços abertos. A análise dos dados deste estudo evidenciou que a inalação do OECL foi capaz de induzir um comportamento ansiolítico em camundongos; entretanto, outros estudos são necessários para garantir o seu uso seguro pela população.Palavras-chave: Ansiolítico. Citrus limon. Óleo essencial. Inalação. Camundongos.

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“…After treatment with R -(+) -limonene or vehicle, animals were individually placed on the central platform facing one of the open arms of the maze, and the number of entries and time spent in each type of arm were recorded for a period of 5 min. Entry into the arm was also considered when the animal was found with all four paws within its limits (Pellow et al, 1985;Bradley et al, 2007;Grundmann et al, 2007).…”

Section: Elevated Plus Maze Test (Epm)mentioning

confidence: 99%

Preclinical evaluation of repeated dose toxicity and anxiolytic activity of monoterpene R - (+) limonene via inhalation

Alves¹,

Alves²,

Ramalho³

et al. 2016

Afr. J. Pharm. Pharmacol.

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R -(+) -limonene is a monoterpene found in several plant species. Studies have shown that plants that have this compound has anxiolytic activity. This study aimed to investigate the anxiolytic and toxicological activity in rats after inhalation of R -(+) -limonene for 30 min. For the anxiety tests using Elevated Plus Maze (EPM), concentrations of 1.0, 2.5 and 5.0% were determined. From the results, it was observed that the last concentration had achieved anxiolytic effect. Based on these results, it was found by biochemical and hematological tests, toxicity of 5% concentration in the period of 30 days with minor significant changes. In the hematological parameters, MCV, MCH and MCHC values were significant when compared to the control group, but were within the normal range when compared to values found in literature. In the biochemical parameters, changes occurred in AST and LDH levels. Elevated LDH levels can cause destruction of erythrocyte precursor cells in the bone marrow. In turn, AST may be associated to small changes in the liver. Therefore, the results demonstrated an anxiolytic activity with low toxicity at dose of 5% R -(+) -limonene via inhalation for 30 min.

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Anxiolytic effects of Lavandula angustifolia odour on the Mongolian gerbil elevated plus maze

Cited by 110 publications

References 40 publications

Phyto-Pharmacological Effect of Nine Medicinal Plants as a Traditional Treatment on Depression

Phyto-Pharmacological Effect of Nine Medicinal Plants as a Traditional Treatment on Depression

Anxiolytic-like effect of Citrus limon (L.) Burm f. essential oil inhalation on mice

Preclinical evaluation of repeated dose toxicity and anxiolytic activity of monoterpene R - (+) limonene via inhalation

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