Phyto-Pharmacological Effect of Nine Medicinal Plants as a Traditional Treatment on Depression

Bakhshaei, Sara

doi:10.21065/1920-4159.1000244

Cited by 4 publications

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References 46 publications

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“…Así, existe una gran cantidad de publicaciones que reportan el uso de plantas medicinales para tratar diversos padecimientos, incluyendo estados de ansiedad, estrés, insomnio y/o alteraciones del sistema nervioso. [15][16][17][18][19] En ese sentido, Aloysia triphylla (cedrón o verbena de limón) es utilizada en la medicina tradicional en varios municipios de la república mexicana [20][21][22][23] por sus propiedades para aliviar el insomnio, como sedante y analgésico, además de otros usos como en indigestión, diarrea, cólicos, etc. [24][25][26] A. triphylla ejerce efectos ansiolíticos en diferentes modelos animales, tanto en ratón mus musculus ICR (Institute of Cancer Research) 27 en el pez bagre (Lophiosilurus alexandri), 28,29 pez cebra (Danio rerio) 24 y en el camarón patiblanco (Litopenaeus vannamei).…”

Section: Introductionunclassified

Análisis in silico de los compuestos de Aloysia triphylla con potencial actividad ansiolítica y predicción de sus propiedades farmacocinéticas

Lobato-Tapia,

Aguilar-Muñoz

2022

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Los trastornos de ansiedad, caracterizados por una preocupación persistente, tienen una prevalencia a nivel mundial que oscila entre un 3.8 a un 25 %. Los tratamientos disponibles producen efectos adversos que, en ocasiones, limitan su continuidad en los pacientes. Una opción al uso de este tipo de tratamientos es el empleo de plantas medicinales con la capacidad de inducir estados de relajación y tranquilidad en quienes las usan, tal es el caso de Aloysia triphylla (cedrón o verbena de limón). El objetivo del presente trabajo es determinar, in silico, la actividad de los diferentes compuestos encontrados en A. triphylla y, evaluar el comportamiento farmacocinético de aquellos compuestos que resulten con mejores actividades con ayuda de la plataforma ADMET lab 2.0. Se realizó la búsqueda de los compuestos reportados en Google Scholar y Pubmed, una vez obtenido el listado, se introdujeron en la plataforma de PASS online para obtener sus actividades más probables. Se eligieron aquellas actividades relacionadas con la ansiedad y a esos compuestos se les evalúo su comportamiento farmacocinético en el servidor ADMET Lab 2.0. Los resultados muestran que, treinta y siete compuestos resultaron con posible actividad ansiolítica, de los cuales, siete resultaron con una probabilidad arriba del 90 % y con unos parámetros farmacocinéticos (estimados) adecuados para futuras administraciones en ensayos preclínicos y clínicos.

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Section: Introductionunclassified

Análisis in silico de los compuestos de Aloysia triphylla con potencial actividad ansiolítica y predicción de sus propiedades farmacocinéticas

Lobato-Tapia,

Aguilar-Muñoz

2022

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Biomedical Implications of Plant-based Principles as Antidepressants: Prospects for Novel Drug Development

Khushboo

Kumar

Sharma

2022

MRMC

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Background: Depression is a most common mental disorder. The symptoms of depression include loss of energy, changes in appetite, more or less sleep, anxiety, low concentration, uncertainty, restlessness, feelings of worthlessness, guilt, or despair, and thoughts of self-harm or suicide. In order to provide safe, efficient and cost-effective medication, the plants based principles in isolation or in combination with traditional antidepressants are attracting increasing attention for depression therapy. Method: The information regarding the present review and its contents such as collected from published literature materials in different international journals. We have used different search engines such as PubMed, Medline, ResearchGate Google Semantic Scholar and ScienceDirect. For this purpose, the data obtained were properly organized and suitably analyzed to include in this article. Results: Most of the phytomolecules isolated from the medicinal plants display antidepressant effect through the synaptic regulation of levels of neurotransmitters such as dopamine, serotonin, and noradrenaline in different parts of the brain. The mechanism of action of phytomolecules also involves negative regulation of the activities of monoamine oxidase (MAO) and acetylcholinesterase (AChE) and prevention of hyperactivity of hypothalamic-pituitary-adrenal (HPA) axis. In addition, the strong antioxidative and antiinflamatory potential of these phytochemicals offer synergy to their antidepressant as well as antipsychosomatic functions. Conclusion: The application of phytochemicals has proved it to be a safe, cost effective and efficient therapeutic agent to treat the patients suffering from mild to severe state of depression and other psychiatric disorders. The potential phytochemicals may be further optimized using in silico tools to develop better antidepressants and antisychotic agents in future.

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Pharmacological Potential of Sweet Violet (Banafsha) on Human Body

Ashfaq

Arshad

Rizwan

2021

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Sweet violet commonly known as Gul-e-Bafasha or Banafsha is a herb widely used as ethnomedicine in dried form in Pakistan for the treatment of various disease or symptoms. Viola odorata had phytochemicals constituents (flavonoids, flavanols, ascorbic acid, phenolics) and antioxidative property Objective: The goal of this research is to emphasize Viola Odorat's (Gul-e-Banafsha) therapeutic benefits on human health. Methods: This review literature is assessed from the previous data available from google scholar, Medline and PubMed. After going through the published articles, researches and literature, initially 104 articles were included, after excluding irrelevant and repeated articles, 37-full text articles and abstract were relevant and found eligible for the study. Results: Sweet violet scientifically known as Viola odorata has been widely used as ethnomedicine in rural areas of Pakistan for the treatment of skin infection, insomnia, inflammation, cough, fever and Cardio Vascular Diseases (CVD) with very low adverse side effects. Its leaves are used as antiseptic used as ointment and its flower has a laxative effect. It is rich in flavonoids like widely known for its therapeutic properties. Due to its phenolic property, it had antioxidant and antimicrobial property, presences of flavonoids had an anti-cancerous effect, it had tannins which reduces the mutagenic activity and it had saponins which reduces blood glucose levels in body. Presence of saponins in Sweet violet lead to the anticarcinogens, melanogenesis, neuroprotective, antimicrobial and anti-inflammatory property. Presence of Isoquinoline alkaloids constituent led to expectorant and antipyretic effect. Viola odorata is used as phytopharmaceuticals and nutraceutical agent. Conclusions: Sweet Voila had acclaimed the therapeutic effect on human health as antiseptic, antifungal, anti-inflammatory, antioxidant, antilipidemic and hepatoprotective activity due to the presences of phenolics, flavonoids, tannins, saponins, alkaloids and coumarins.

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Phyto-Pharmacological Effect of Nine Medicinal Plants as a Traditional Treatment on Depression

Cited by 4 publications

References 46 publications

Análisis in silico de los compuestos de Aloysia triphylla con potencial actividad ansiolítica y predicción de sus propiedades farmacocinéticas

Análisis in silico de los compuestos de Aloysia triphylla con potencial actividad ansiolítica y predicción de sus propiedades farmacocinéticas

Biomedical Implications of Plant-based Principles as Antidepressants: Prospects for Novel Drug Development

Pharmacological Potential of Sweet Violet (Banafsha) on Human Body

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