Anxiety, diazepam and retrieval from semantic memory

Hartley, L. R.; Spencer, Justine M. Y.; Williamson, James R.

doi:10.1007/bf00432564

Cited by 17 publications

(8 citation statements)

References 9 publications

Supporting

Mentioning

Contrasting

Order By: Relevance

“…Several studies performed in humans have reported that positive GABA A modulators can improve learning and memory in "anxious" subjects, whereas they produce disruptions in "nonanxious" subjects (Hartley et al 1982;Desai et al 1983). A similar profile of effects was shown in a study by Campbell et al (2004), where the benzodiazepine triazolam increased errors in squirrel monkeys responding on a repeated acquisition of behavioral chains procedure, but the same dose decreased errors when responding in the repeated-acquisition procedure was disrupted by response-independent tail shocks.…”

Section: Discussionmentioning

confidence: 53%

Interaction of cocaine with positive GABAA modulators on the repeated acquisition and performance of response sequences in rats

et al. 2005

View full text Add to dashboard Cite

show abstract

Section: Discussionmentioning

confidence: 53%

Interaction of cocaine with positive GABAA modulators on the repeated acquisition and performance of response sequences in rats

et al. 2005

View full text Add to dashboard Cite

show abstract

“…Thus, memory impairment appeared to occur for only a brief time in the chronic users following intake of their medication, but was not continuously altered despite the persistent concentrations of BZs measured in plasma. A number of BZ medications have been reported to produce effects resembling short-term anterograde amnesia when administered acutely to normal volunteers (Ghoneim and Mewaldt 1975) or to anxious subjects (Angus and Romney 1984;Hartley et al 1982). These effects appear to be due to an inability to consolidate new information into long-term memory storage, although immediate memory and information learned prior to drug administration are not affected by acute BZ administration (for review, see Lister 1985).…”

Section: Discussionmentioning

confidence: 99%

Chronic use of benzodiazepines and psychomotor and cognitive test performance

1986

View full text Add to dashboard Cite

The performance of 43 long-term users (average = 5 years) of benzodiazepine (BZ) medications was examined on a battery of behavioral tasks, cognitive tests, and subjective mood rating scales. The performance of the chronic BZ users did not differ significantly from age- and sex-matched anxious subjects, except that critical flicker fusion (CFF) thresholds were lower and subjective ratings of tranquilization were higher in the BZ users. Twenty-two subjects were reexamined in order to determine the acute effects of BZ medications in long-term users. The acute administration of BZ medications significantly increased CFF thresholds, improved digit-symbol substitution test performance, impaired the delayed recall of verbal material, increased subjective ratings of tranquilization, and reduced physical sedation. Motor performance tests were not impaired and subjective feelings of sedation were not increased after the acute administration of BZs by chronic users. During withdrawal from long-term BZ use (17 subjects), CFF thresholds were elevated, subjective ratings of physical sedation and anxiety were increased, but performance on other psychomotor and cognitive tests was not altered. The results suggest that tolerance develops selectively to different behavioral and subjective effects of BZ medications with their continued use. Tolerance failed to develop to the antianxiety effects, the reduction of CFF threshold, and to the impairment of short-term memory caused by BZs. However, chronic users of BZ medications failed to demonstrate psychomotor-impairing or sedating effects to BZ medications. The results have implications for evaluating the safety of the long-term use of BZ medications.

show abstract

Section: Allosteric Modulators Of Gabaa Receptorsmentioning

confidence: 99%

“…Although perhaps less relevant to the processes underlying dementia, it is worth noting that administration of BZDs has also been correlated with acute reductions in cognitive performance, including impairments in semantic memory immediately following oral administration (Hartley et al 1982;Ghoneim et al 1984;Roy-Byrne et al 1987), and alterations in emotional processing following short-term use (Pringle et al 2016). Indeed, the amnesic effects of BZD drugs in humans are well-attested, first having been observed by anesthesiologists utilizing BZDs (Haslett and Dundee 1968).…”

Section: Benzodiazepinesmentioning

confidence: 99%

The GABAergic system as a therapeutic target for Alzheimer's disease

Guzmán

Vinnakota

Govindpani

et al. 2018

Journal of Neurochemistry

129

View full text Add to dashboard Cite

Glutamatergic and cholinergic dysfunction are well-attested features of Alzheimer's disease (AD), progressing with other pathological indices of the disorder and exacerbating neuronal and network dysfunction. However, relatively little attention has been paid to the inhibitory component of the excitatory/inhibitory (E/I) network, particularly dysfunction in the gamma-aminobutyric acid (GABA) signaling system. There is growing evidence in support of GABAergic remodeling in the AD brain, potentially beginning in early stages of disease pathogenesis, and this could thus be a valid molecular target for drug development and pharmacological therapies. Several GABAergic drugs have been tested for efficacy in attenuating or reversing various features and symptoms of AD, and this could represent a novel path by which we might address the growing need for more effective and benign therapies.

show abstract

Anxiety, diazepam and retrieval from semantic memory

Cited by 17 publications

References 9 publications

Interaction of cocaine with positive GABAA modulators on the repeated acquisition and performance of response sequences in rats

Interaction of cocaine with positive GABAA modulators on the repeated acquisition and performance of response sequences in rats

Chronic use of benzodiazepines and psychomotor and cognitive test performance

The GABAergic system as a therapeutic target for Alzheimer's disease

Contact Info

Product

Resources

About