Anxiety and Depression Are Correlated With Higher Morbidity After Kidney Transplantation

Noohi, Sima; Khaghanizadeh, M; Javadipour, Morteza; Assari, Shervin; Najafi, Mahdi; Ebrahiminia, Mohammad Reza; Pourfarziani, Vahid

doi:10.1016/j.transproceed.2007.04.002

Cited by 81 publications

(76 citation statements)

References 26 publications

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“…5,6 Among kidney transplant (kTx) recipients, depression is associated with reduced adherence and also with increased morbidity, graft loss, and mortality. [7][8][9][10][11][12][13] Poor sleep and various sleep problems are also frequent complaints among kTx recipients.…”

Section: Introductionmentioning

confidence: 99%

Depressive Symptoms Are Associated With Objectively Measured Sleep Parameters in Kidney Transplant Recipients

Rónai

Szentkirályi

Lázár

et al. 2017

Journal of Clinical Sleep Medicine

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Study Objectives: Both depression and sleep complaints are very prevalent among kidney transplant (kTx) recipients. However, details of the complex relationship between sleep and depression in this population are not well documented. Thus, we investigated the association between depressive symptoms and sleep macrostructure parameters among prevalent kTx recipients. Methods: Ninety-five kTx recipients participated in the study (54 males, mean ± standard devation age 51 ± 13 years, body mass index 26 ± 4 kg/m 2 , estimated glomerular filtration rate 53 ± 19 ml/min/1.73 m 2 ). Symptoms of depression were assessed by the Center for Epidemiologic Studies -Depression Scale (CES-D). After 1-night polysomnography each recording was visually scored and sleep macrostructure was analyzed. Results: The CES-D score was significantly associated with the amount of stage 2 sleep (r = 0.20, P < .05), rapid eye movement (REM) latency (r = 0.21, P < .05) and REM percentage (r = −0.24, P < .05), but not with the amount of slow wave sleep (r = −0.12, P > .05). In multivariable linear regression models the CES-D score was independently associated with the amount of stage 2 sleep (β: 0.205; confidence interval: 0.001-0.409; P = .05) and REM latency (β: 0.234; confidence interval: 0.001-0.468; P = .05) after adjustment for potential confounders. I NTRO DUCTI O NDepression is one of the most prevalent mental health conditions in patients with chronic kidney disease (CKD) [1][2][3][4] ; furthermore, it is an important determinant of impaired quality of life. 5,6 Among kidney transplant (kTx) recipients, depression is associated with reduced adherence and also with increased morbidity, graft loss, and mortality. [7][8][9][10][11][12][13] Poor sleep and various sleep problems are also frequent complaints among kTx recipients.14,15 Earlier we reported that chronic insomnia was independently associated with the presence of depression in kTx recipients. 16 In the general population there is a strong and bidirectional relationship between depression and sleep.17 This is also reflected in the Diagnostic and Statistical Manual of Mental Disorders, Fifth Edition definition of major depression (MD), 18 as sleep complaints are core symptoms of MD. Several objective sleep parameters are different in patients with MD than in healthy control patients. Patients with MD have decreased amounts of slow wave sleep (SWS) and shortened rapid eye movement (REM) latency with increased amounts of REM sleep. The exact mechanisms and factors that may link depression to poor clinical outcomes among kTx recipients are not yet well defined. In a recent review focusing on kTx and depression, 23 sleep is not mentioned. This may be due to the complete lack of polysomnography (PSG) studies that assess the association between sleep and depression in this population. The frequent co-occurrence of subjective sleep complaints and depression among kTx recipients 16 suggests that the relationship between the two conditions may be similar to the association described in the g...

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Section: Introductionmentioning

confidence: 99%

Depressive Symptoms Are Associated With Objectively Measured Sleep Parameters in Kidney Transplant Recipients

Rónai

Szentkirályi

Lázár

et al. 2017

Journal of Clinical Sleep Medicine

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“…[35][36][37][38][39][40] Among the domains that stood out in this research, when compared to both groups, there are validity (p = 0.000), functional capacity (p = 0.001), pain (p = 0.027) and general health status (p = 0.049). In a certain study 29 , there were no significant statistically differences in relation to the quality of life, when compared to the groups in the treatment of hemodialysis, in peritoneal dialysis and kidney transplant. However, it was verified that the component vitality presented a higher score in the group of renal transplant, as it was found in this study.…”

Section: Erro! Indicador Não Definidomentioning

confidence: 82%

“…13,27 Other causes often related to depression in patients in hemodialysis treatment are: complaints on malaise, cramps, sudden drops in blood pressure, presence of arteriovenous fistula and bias for insertion into the labor market 28 , as well as poor treatment adherence. 29 The problems experienced by patients with chronic kidney disease have a negative quality of life 5,11,23, , as seen in table 6, in which virtually all domains related to quality of life were lower compared to kidney transplantation, as described by the authors. 23,32 Other reason that may cause depression in patients with CRF that are in the wating list for a transplant consists possibly in the form of confronting the new situation.…”

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confidence: 88%

“…As for hemodialysis, the research 29,48 , demonstrated that patients with less time of treatment of dialysis presented higher scores for QOL, the same occuring with patients that did not have treatment of dialysis before the transplantation. However, in relation to the transplant patients that were subjected to dialysis before the surgery, it was not perceveid in this study significant effects on QOL.…”

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confidence: 95%

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Depressão e qualidade de vida em pacientes no pré e pós-transplante renal

Barros

Araújo²,

Lima³

2018

Rev enferm UFPE on line.

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Objective: to analyze the occurrence of depression and quality of life in renal patients before and after transplantation. Method: quantitative, descriptive, exploratory, cross-sectional study. Three instruments were used to collect data: a questionnaire for characterization of the sample, the Beck depression inventory (BDI) and the SF-36 questionnaire, to evaluate the quality of life. The sample consisted of two groups: one in pre-transplant patients (59 patients) and the other in renal transplant patients (63 patients), totaling 122 patients. Results: the majority of patients, in both groups, did not present depression, corresponding to 88.9% of the transplanted patients and 79.6% of the pre-transplant patients. Quality of life was higher in transplant patients than in those awaiting the procedure. The SF-36 domains that determined the best quality of life in the transplanted patients were functional capacity (p = 0.001), pain (p = 0.027), general health status (p = 0.049) and vitality (p = 0.000). Conclusion: this study showed a low occurrence of depression in patients both in the pre-and post-renal transplantation. Quality of life was higher in the transplant group. Descriptors: Depression, Quality of Life; Organ Transplantation; Chronic Disease. RESUMOObjetivo: analisar a ocorrência de depressão e a qualidade de vida em pacientes renais no pré e pós-transplante. Método: estudo quantitativo, descritivo, exploratório, de coorte transversal. Foram aplicados três instrumentos para a coleta de dados: um questionário para caracterização da amostra, o inventário Beck de depressão (BDI) e o questionário SF-36, para avaliação da qualidade de vida. A amostra foi composta por dois grupos, um de pacientes no pré-transplante renal (59 pacientes) e o outro de transplantados renais (63 pacientes), totalizando 122 pacientes. Resultados: a maioria dos pacientes, em ambos os grupos, não apresentava depressão, correspondendo a 88,9% dos transplantados e 79.6% de pacientes no pré-transplante. A qualidade de vida mostrou-se superior nos pacientes transplantados em relação aos que aguardavam o procedimento. Os domínios do questionário SF-36 que determinaram a melhor qualidade de vida nos pacientes transplantados foram capacidade funcional (p = 0,001), dor (p = 0,027), estado geral de saúde (p = 0,049) e vitalidade (p = 0,000). Conclusão: esse estudo mostrou uma baixa ocorrência de depressão nos pacientes tanto no pré, como no pós-transplante renal. A qualidade de vida mostrou-se superior no grupo de transplantados. Descritores: Depressão, Qualidade De Vida; Transplante de Órgãos; Doença Crônica. RESUMENObjetivo: analizar la ocurrencia de depresión y la calidad de vida en pacientes renales en el pre y posttrasplante. Método: estudio cuantitativo, descriptivo, exploratorio, de cohorte transversal. Se aplicaron tres instrumentos para la recolección de datos: un cuestionario para la caracterización de la muestra, el inventario Beck de depresión (BDI) y el cuestionario SF-36, para la evaluación de la calidad de vida. La muest...

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“…zaburzenia depresyjne, lękowe, psychotyczne, zachowania samobójcze, zaburzenia snu oraz dysfunkcje seksualne [7,8]. W piśmiennictwie podkreśla się fakt, iż wystąpienie depresji u biorcy przeszczepu nerki jest niezależnym czynnikiem ryzyka zwiększonej chorobowości, gorszego funkcjonowania przeszczepu, jego odrzucenia i konieczności powrotu do dializ, a także śmierci [9,10,11,12]. Za przyczyny występowania zaburzeń depresyjnych w tej grupie pacjentów uznaje się współ-istnienie czynników patofizjologicznych (np.…”

Section: Wstępunclassified

Organiczne zaburzenia urojeniowe u pacjentki po przeszczepie nerki – opis przypadku

Bąba-Kubiś

Pełka-Wysiecka

Liśkiewicz

et al. 2018

Pomeranian J Life Sci

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Introduction: This paper presents the case of a patient diagnosed with organic delusional disorder. Medical history revealed that the psychiatric symptoms increased gradually after the patient received a renal transplant from a deceased donor. Case report: A 42-year-old patient was admitted to a psychiatric ward for observation and, if necessary, modification of prior clinical diagnosis. Commentary: Psychotic symptoms in the form of delusions of reference, persecution, and auditory hallucinations occurred a few weeks after the renal transplantation from a deceased donor. The intensity of these symptoms had the tendency to increase. At that time the patient was treated with increased doses of immunosuppressive medications, in line with post-transplant treatment standards. Dose reductions had no observable effect on the psychiatric symptoms. The patient is also suffering from Hashimoto thyroiditis, hypertension, hepatitis type B, thrombosis of internal carotid artery, and diabetes mellitus type 2 with nephropathy, retinopathy, and neuropathy. Conclusions: This case report is an example of the multifactorial aetiology of psychopathological symptoms. It also shows the need to consider many aspects of the patient's somatic state while determining psychiatric diagnosis and planning treatment. Keywords: psychotic disorders; renal transplantation; immunosuppressive medications; systemic lupus erythematosus. ABSTRAKT Wstęp: W niniejszym artykule przedstawiono przypadek pacjentki chorującej na organiczne zaburzenia urojeniowe. Początek objawów psychiatrycznych następował stopniowo w okresie kilku tygodni po przeszczepieniu pacjentce nerki od zmarłego dawcy. Opis przypadku: 42-letnia pacjentka została przyjęta na oddział psychiatrii w celu obserwacji stanu psychicznego oraz ewentualnej modyfikacji postawionego wcześniej rozpoznania klinicznego. Komentarz: Objawy psychotyczne o charakterze urojeń ksobnych, prześladowczych oraz omamów słuchowych pojawiły się u pacjentki w okresie kilku tygodni po przeszczepie nerki od zmarłego dawcy. Objawy te miały tendencję do stopniowego nasilania się. Zgodnie ze standardami postępowania potransplantacyjnego pacjentka przyjmowała zwiększone dawki leków immunosupresyjnych, jednak mimo redukcji dawek objawy psychotyczne nie uległy zmniejszeniu. Pacjentka obcią-żona była somatycznie chorobą Hashimoto, nadciśnieniem tęt-niczym, wirusowym zapaleniem wątroby typu B, zakrzepicą tętnicy szyjnej wewnętrznej, cukrzycą typu 2 powikłaną nefropatią, retinopatią i neuropatią. Wnioski: Przedstawiony przypadek stanowi przykład wieloczynnikowej etiologii objawów psychopatologicznych oraz wskazuje na konieczność uwzględniania wielu aspektów stanu somatycznego przy ustalaniu diagnozy psychiatrycznej i planowaniu leczenia pacjenta. Słowa kluczowe: zaburzenia psychotyczne; transplantacja nerki; leczenie immunosupresyjne; toczeń rumieniowaty układowy. WSTĘPTransplantologia jest gałęzią medycyny, która wciąż wzbudza dużo kontrowersji oraz emocji w społeczeństwie. Według danych Poltransplantu w 2016 r. l...

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Anxiety and Depression Are Correlated With Higher Morbidity After Kidney Transplantation

Cited by 81 publications

References 26 publications

Depressive Symptoms Are Associated With Objectively Measured Sleep Parameters in Kidney Transplant Recipients

Depressive Symptoms Are Associated With Objectively Measured Sleep Parameters in Kidney Transplant Recipients

Depressão e qualidade de vida em pacientes no pré e pós-transplante renal

Organiczne zaburzenia urojeniowe u pacjentki po przeszczepie nerki – opis przypadku

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