Antiviral and Antibacterial Properties of synthesis Silver Nanoparticles with Nigella arvensis Aqueous Extract

Abstract

As a result of the emergence of new virus strains and the synthetics, virus infections pose significant global health challenges, so the need for new therapeutic drugs rises as new vi and bacterial infectious diseases emerge. This study aimed to synth extract and investigate their possible antiviral and antibacterial properties. X microscopy, and UV-Visible spectroscopy were used to validate the synthesis of Ag-NPs production through the shift from yellow color to dark brown color. TEM examination of Ag nanoparticles with mean sizes ranging from 2 to 9 nm and an average particle diameter of 2.5 spectrophotometric investigation revealed an absorption peak at action against the four studied bacteria, with the inhibition zones for Bacillus subtilis ranging from 6 to 25 mm, Staphylococcus aureus from 8 to 25 mm, and Escherichia coli from 10 to 19 mm, whereas Pseudomonas aeruginosa has shown resistance to the AgNPs solution. The MBC varied from 22.3 to 36.8 nanoparticles against the chosen bacterial strains ranged from 5.7 to 10.2 concentration (MNTC) of Ag-NPs, 10.56 µg/mL, the greenly generated Ag antiviral efficacy against HSV-1, HAV, and adenovirus Finally, The novelty in this study is the application of silver nanoparticles as an antiviral against HSV adenovirus because of the high mutation of viruses.

Identifying the Anti-MERS-CoV and Anti-HcoV-229E Potential Drugs from the Ginkgo biloba Leaves Extract and Its Eco-Friendly Synthesis of Silver Nanoparticles

“…Nevertheless, only a small number of them have been used for therapeutic against viruses. A logical hypothesis would be to begin researching the properties and advantages of GB extract and Ag NPs as an antiviral versus the MERS-CoV and HCoV-229E based on our prior work on the conjugation of GB extract as a natural product and Ag NPs as an environmental nanoparticle synthesis [ 12 , 93 ].…”

“…Among the transitional elements, silver nanoparticles (Ag NPs) are a novel nanometal particle form widely incorporated in biological, therapeutic, and engineering disciplines [ 10 ]. In particular, synthetic biologically active Ag NPs have demonstrated substantial therapeutic aptitudes, including broad-spectrum antimicrobial, anticancer, anti-inflammatory, antioxidative, and antidiabetic action [ 11 , 12 ]. A modern review of the synthesis of Ag NPs and their uses in antimicrobial textile fabrics, food packaging films, and wound dressings is provided by Chengzhu L. et al The antibacterial activity and cytotoxic effect in mammalian cells are given special consideration [ 13 ].…”

Phytotoxicity and Antimicrobial Activity of Green Synthesized Silver Nanoparticles Using Nigella sativa Seeds on Wheat Seedlings

“…Te Ag ions could be reduced by the action of favonoids, alkaloids, and polyphenols in the N. sativa seed extract [66]. [ [69][70][71][72]. Tis analysis revealed that nanoparticles are orthorhombic crystals.…”

In vitro and in silico biopotentials of phytochemical compositions and antistaphylococcal and antipseudomonal activities of volatile compounds of Argania spinosa (L.) seed oil

“…It has also been reported that argan oil has antibacterial activity against methicillin-resistant Staphylococcus aureus and Pseudomonas aeruginosa . Moreover, the studies indicated that treatment with argan oil alone did not yield any or had very low antibacterial activity against methicillin-resistant Staphylococcus aureus and Pseudomonas aeruginosa , respectively ( Naher et al, 2014 ; Elnosary et al, 2022 ). A study by Stojkovic et al (2013 ) found that the naturally occurring compounds, caffeic acid, p-coumaric acid, and rutin, present in argan oil could inhibit Staphylococcus aureus growth.…”