Antiviral Activity of Some Iraqi Indigenous Plants

Alwan, Ali Hussein; Jawad, Abdul-Latif M.; Al-Bana, Anton S.; Ali, K. F.

doi:10.3109/13880208809053901

Cited by 10 publications

(6 citation statements)

References 4 publications

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“…Additionally, previous results using aqueous and ethanolic extracts from T. polium aerial parts have shown moderate anti-rinderpest virus [ 80 ]. In 2014, Ansari and co-workers [ 81 ] reported that T. polium was a rich source of rosmarinic acid (1.8%, w/w ), weak cytotoxic activity (maximum non-toxic concentration = 1000 μg/mL), and anti-Herpes Simplex Virus-1 (HSV-1)—affected by the exposure time and the concentration of the extract used.…”

Section: Discussionmentioning

confidence: 97%

Phytochemical Screening, Antibacterial, Antifungal, Antiviral, Cytotoxic, and Anti-Quorum-Sensing Properties of Teucrium polium L. Aerial Parts Methanolic Extract

Alreshidi

Noumi

Bouslama

et al. 2020

Plants

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The chemical profile of Teucrium polium L. (T. polium) methanolic extract was tested using liquid chromatography coupled with high resolution mass spectrometry (HR-LCMS). Disc diffusion and microdilution assays were used for the antimicrobial activities. Coxsackievirus B-3 (CVB3) and Herpes simplex virus type 2 (HSV-2) were used for the antiviral activities. Chromobacterium violaceum (ATCC 12472 and CV026) and Pseudomonas aeruginosa PAO1 were used as starter strains for the anti-quorum sensing tests. Isoprenoids are the main class of compounds identified, and 13R-hydroxy-9E,11Z-octadecadienoic acid, valtratum, rhoifolin, sericetin diacetate, and dihydrosamidin were the dominant phytoconstituents. The highest mean diameter of growth inhibition zone was recorded for Acinetobacter baumannii (19.33 ± 1.15 mm). The minimal inhibitory concentrations were ranging from 6.25 to 25 mg/mL for bacterial strains, and from 6.25 to 25 mg/mL for Candida species. The 50% cytotoxic concentration on VERO (African Green Monkey Kidney) cell lines was estimated at 209 µg/mL. No antiviral activity was recorded. Additionally, T. polium extract was able to inhibit P. aeruginosa PAO1 motility in a concentration-dependent manner. However, the tested extract was able to inhibit 23.66% of the swarming and 35.25% of swimming capacities of PAO1 at 100 µg/mL. These results highlighted the role of germander as a potent antimicrobial agent that can interfere with the virulence factors controlled by the quorum-sensing systems.

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Section: Discussionmentioning

confidence: 97%

Phytochemical Screening, Antibacterial, Antifungal, Antiviral, Cytotoxic, and Anti-Quorum-Sensing Properties of Teucrium polium L. Aerial Parts Methanolic Extract

Alreshidi

Noumi

Bouslama

et al. 2020

Plants

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“…Relative to antibacterial studies, much less work has been devoted to the antiviral evaluation of T. polium various extracts. In a study performed by Alwan et al (), the ethanol extract of T. polium has been evaluated for its activity against rinderpest virus (RPV) using an agar‐overlay plaque‐reduction antiviral assay system. Their results indicated that the aqueous and ethanol extracts of T. polium had moderate antiviral activity.…”

Section: Biological Propertiesmentioning

confidence: 99%

Phytochemistry and Medicinal Properties of Teucrium polium L. (Lamiaceae)

Bahramikia

Yazdanparast

2012

Phytotherapy Research

116

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Teucrium polium L. (family Lamiaceae) is a wild-growing flowering plant, found abundantly in South-Western Asia, Europe and North Africa. Traditionally, T. polium has been used for different pathological conditions such as gastrointestinal disorders, inflammations, diabetes and rheumatism. In traditional Iranian medicine (TIM), the tea of T. polium is used for treating many diseases such as abdominal pain, indigestion, common cold and type 2 diabetes. Based on this background, many studies have been followed for scientific confirmation of the above-mentioned properties. In this review, 100 articles published from 1970 to 2011 in the area of phytochemistry, pharmacology and toxicology of extracts and compounds isolated from T. polium have been evaluated. During the past 40 years, different classes of compounds have been isolated from various parts of T. polium of which the main groups are terpenoids and flavonoids. It has been found that these compounds possess a broad spectrum of pharmacological effects including antioxidant, anticancer, antiinflammatory, hypoglycemic, hepatoprotective, hypolipidemic, antibacterial and antifungal. The results of data analyses on the chemical, pharmacological and toxicological characteristics of T. polium support the view that this plant has beneficial therapeutic properties. However, further studies to identify the active components and further verify their relevant pharmacological activities are warranted.

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“…The anti-viral activity is widely tested in various extracts of Pimpinella anisum on different viruses. The first test was realized in Iraq when Alwan et al [ 89 ] studied the antiviral activity of aqueous and ethanolic extract of 17 plant species including Pimpinella anisum against rinderpest virus (RPV). However, during antiviral in vivo and in vitro tests, the inhibitory effects were variable depending on the viruses and used Pimpinella anisum materials.…”

Section: Pharmacological Propertiesmentioning

confidence: 99%

A Multidimensional Review of Pimpinella anisum and Recommendation for Future Research to Face Adverse Climatic Conditions

Soussi

Yaagoubi²,

Nekhla³

et al. 2023

Chemistry Africa

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Anise, or Pimpinella anisum , has a long history of usage in traditional and alternative medicine, as well as in the pharmaceutical sector . The species is native to Southwest Asia, the Middle East, and the Mediterranean region. The current studies have revealed that wild and cultivated P. anisum are rich in bioactive compounds, such as phenols, tannins, carotenoids, and fatty acids. Different parts of P. anisum plant are used treatment of diseases, the treatment of pathogens for antiviral, antibacterial, and antifungal purposes, and cosmetics. In this paper, we reviewed the current knowledge on geographical distribution, cultivation, chemical compounds, extraction methods, and agronomic and medicinal uses of Pimpinella anisum . Equally, we suggested guidelines for future research to fill the gap in less investigated issues. Data for this paper was gathered via electronic literature search on Google, Google Scholar, and databases counting, Science Direct, Scopus, Springer, PubMed, and Hindawi, from 1930 to 2022. Analyzed data show that Pimpinella anisum is currently recorded from Portugal on the Atlantic Ocean in the west to China in the East. With new extraction methods, such as Ultrasound-Assisted Extraction, scientists have explored the higher quantities of polyphenols, flavonoids, and antioxidants, and revealed new constituents such as trans-anethole and estragole found in essential oil fruits by gas chromatography-mass spectrometry (GC–MS). These compounds showed significant therapeutic benefits against diseases, pathogens, and cosmetic roles. However, with the current impacts of climate change on natural vegetation cover, more investigations are needed to understand how these affect the geographical distribution, metabolic aspects, and chemical properties of Pimpinella anisum. These are suggested to increase the value of the species and ensure its conservation.

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Antiviral Activity of Some Iraqi Indigenous Plants

Cited by 10 publications

References 4 publications

Phytochemical Screening, Antibacterial, Antifungal, Antiviral, Cytotoxic, and Anti-Quorum-Sensing Properties of Teucrium polium L. Aerial Parts Methanolic Extract

Phytochemical Screening, Antibacterial, Antifungal, Antiviral, Cytotoxic, and Anti-Quorum-Sensing Properties of Teucrium polium L. Aerial Parts Methanolic Extract

Phytochemistry and Medicinal Properties of Teucrium polium L. (Lamiaceae)

A Multidimensional Review of Pimpinella anisum and Recommendation for Future Research to Face Adverse Climatic Conditions

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