Antiviral activity of lignans and their glycosides from Justicia procumbens

Asano, Jun; Chiba, Kazuhiro; Tada, Mizuki; Yoshii, Takao

doi:10.1016/0031-9422(96)00024-6

Cited by 121 publications

(91 citation statements)

References 10 publications

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“…betonica EtOH Munakata et al, 1965Day et al, 1999J. procumbens MeOH Fukamiya & Lee, 1986Asano et al, 1996;Chen et al, 1996;Su et al, 2006 J …”

Section: J Purpureamentioning

confidence: 99%

“…The antiplatelet aggregation activity of lignans 25, 26, 28, 29, 38, 40, and 52 are related to the pharmacological tests of the methanol extract of J. procumbens (Table 3). Lignans 29, 30, 31, 53, and 54 showed strong antiviral activity against vesicular stomatitis virus and low cytotoxicity against cultured rabbit lung cells (RL-33) (Asano et al, 1996). Lignans 29 and 43 showed inhibition of secondary aggregation induced by adrenaline (Wu et al, 2007).…”

Section: Biological Activity Of Compounds Isolated From Species Of Jumentioning

confidence: 99%

“…MeOH Baba et al, 1996;Gertsch et al, 2003;Kavitha et al, 2003;Rao et al, 2006;Wu et al, 2007;Kaur et al, 2009 J. procumbens EtOH Chen et al, 1996MeOH Asano et al, 1996 Diphyllin (30) Cytotoxycity and antiviral J. extensa EtOH Wang & Ripka, 1983 J. procumbens MeOH Fukamiya & Lee, 1986;Chen et al, 1996;Asano et al, 1996 J. ciliata MeOH Day et al, 1999EtOH Wang & Ripka, 1983J. betonica EtOH Munakata et al, 1965Day et al, 1999J.…”

Section: J Purpureamentioning

confidence: 99%

“…Lignans also show antiangiogenic, antileishmanial, antifungal, hypolipidemic, antiasthmatic (Vasilev & Ionkova, 2005), antiviral (Asano et al, 1996), antineoplastic (Gordaliza et al, 2000), antifeedant (Bedoya et al, 2008), insecticidal, cardiotonic, antidepressant (Ghosal et al, 1979), analgesic, antiplatelet (Chen et al, 1996), and anti-inflammatory (Navarro et al, 2004) indications, as well as activity as lipid peroxidation inhibitors. Potent anti-inflammatory activities were described for lignan glycosides isolated from J. ciliata (Day et al, 2000) and phenolic compounds isolated from J. prostrata (Sanmugapriya et al, 2005b).…”

Section: Compounds Isolated From Species Of Justiciamentioning

confidence: 99%

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Chemical constituents and biological activities of species of Justicia: a review

Corrêa¹,

Alcântara²

2012

Rev. bras. farmacogn.

122

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Abstract:The Acanthaceae family is an important source of therapeutic drugs, and the ethnopharmacological knowledge of this family requires urgent documentation as several of its species are near extinction. Justicia is the largest genus of Acanthaceae, with approximately 600 species. The present work provides a review addressing the chemistry and pharmacology of the genus Justicia. In addition, the biological activities of compounds isolated from the genus are also covered. The chemical and pharmacological information in the present work may inspire new biomedical applications for the species of Justicia, considering atom economy, the synthesis of environmentally benign products without producing toxic by-products, the use of renewable sources of raw materials, and the search for processes with maximal efficiency of energy.

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“…betonica EtOH Munakata et al, 1965Day et al, 1999J. procumbens MeOH Fukamiya & Lee, 1986Asano et al, 1996;Chen et al, 1996;Su et al, 2006 J …”

Section: J Purpureamentioning

confidence: 99%

Section: Biological Activity Of Compounds Isolated From Species Of Jumentioning

confidence: 99%

Section: J Purpureamentioning

confidence: 99%

Section: Compounds Isolated From Species Of Justiciamentioning

confidence: 99%

See 2 more Smart Citations

Chemical constituents and biological activities of species of Justicia: a review

Corrêa¹,

Alcântara²

2012

Rev. bras. farmacogn.

122

View full text Add to dashboard Cite

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“…The bioactive justicins isolated from J. procumbens in the past few years included diphyllin, 6′-hydroxy justicidin A (HJA), and chinensinaphthol methyl ether (CME), which each have a chemical structure similar to that of POD (10 -12). These justicins were proved to have a wide spectrum of biological activities, such as cytotoxicity (13 -15), antimicrobial (16), anti-platelet (17), and antiviral activities (18). A new justicin 6′-hydroxy justicidin C (HJC) was for the first time isolated from J. procumbens.…”

Section: Introductionmentioning

confidence: 99%

HJC, a New Arylnaphthalene Lignan Isolated From Justicia procumbens, Causes Apoptosis and Caspase Activation in K562 Leukemia Cells

2014

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Abstract. The aim of this study is to investigate whether HJC, isolated from Justicia procumbens for the first time, can suppress the proliferation and induce apoptosis of human leukemia K562 cells and finally clarify its related mechanism. The chemical structure of HJC was validated by LC-ESI-MS/MS, cytotoxicity was assayed using MTT, and apoptosis was investigated by flow cytometry. These assays indicated that HJC remarkably inhibited the growth in K562 cells by decreasing cell proliferation, reducing the SOD activity, enhancing ROS levels and inducing apoptosis. Activation of caspase-3 indicated that HJC may be inducing intrinsic and extrinsic apoptosis pathways and that HJC-induced apoptosis was caspase-dependent. This study suggests that HJC is a high-potency anti-tumor agent, and it induces apoptosis through a caspase-dependent pathway in human leukemia K562 cells. It also presents a potential alternative to leukemia therapy.

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