Antiviral activity of Distictella elongata (Vahl) Urb. (Bignoniaceae), a potentially useful source of anti-dengue drugs from the state of Minas Gerais, Brazil

Simoes, Leandro Ribeiro; Maciel, Glauber Meireles; Brandão, Geraldo Célio; Kroon, Erna Geessien; Castilho, Rachel Oliveira; Oliveira, Alaı́de Braga de

doi:10.1111/j.1472-765x.2011.03146.x

Cited by 42 publications

(26 citation statements)

References 18 publications

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“…ex D. Don of Adoxaceae . For what concerns the bioactivity context, this compound exerts good analgesic, anti‐inflammatory, hepato‐protective, and cytotoxic effects …”

Section: Resultsmentioning

confidence: 99%

Iridoids of Chemotaxonomy Relevance, a New Antirrhinoside Ester and Other Constituents from Kickxia spuria subsp. integrifolia (Brot.) R.Fern.

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Frezza

Serafini

et al. 2018

Chemistry & Biodiversity

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In this work, the secondary metabolite content of the EtOH extract of Kickxia spuria subsp. integrifolia (Brot.) R.Fern. is reported. Fourteen compounds were isolated and identified by means of column chromatography and NMR and MS instrumental techniques, respectively. Among the identified compounds, the chemotaxonomic markers of the species were evidenced, whereas others were reported for the first time in the genus. Among these, a new antirrhinoside derivative (12) was recognized. The iridoid content showed a molecular pattern very similar to those reported for other taxa comprised in the Antirrhinae tribe of Plantaginaceae, thus providing an additional evidence that supports the current botanical classification of the Kickxia genus. Anyway, most of the recognized components are able to exert important pharmacological properties which might suggest the possible employment of also this species in traditional medicine just like it happens for some other species of the Kickxia genus.

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“…ex D. Don of Adoxaceae . For what concerns the bioactivity context, this compound exerts good analgesic, anti‐inflammatory, hepato‐protective, and cytotoxic effects …”

Section: Resultsmentioning

confidence: 99%

Iridoids of Chemotaxonomy Relevance, a New Antirrhinoside Ester and Other Constituents from Kickxia spuria subsp. integrifolia (Brot.) R.Fern.

Venditti

Frezza

Serafini

et al. 2018

Chemistry & Biodiversity

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“…Other Bignoniaceae family species with antivirus activity have been previously reported including in vitro anti- Dengue virus type 2 activity, a flavivirus that has a genetic and serological relationship with the Zika virus , of Fridericia sp. [5; 8], Distictella elongate [ 39 ], Xylofragma myrianthum [ 40 ]. Markhamia lutea extract presented in vitro activity against Respiratory syncytial virus [ 6 ].…”

Section: Discussionmentioning

confidence: 99%

Anti-Zika virus activity and chemical characterization by ultra-high performance liquid chromatography (UPLC-DAD-UV-MS) of ethanol extracts in Tecoma species

Reis

Silva

Moura

et al. 2020

BMC Complement Med Ther

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Background Plant species from the genus Tecoma are found in tropical and subtropical regions around the world. Some of them are grown as ornamental plants and others can be used as medicinal plants. In the present study, ethanolic extracts from trunks and leaves of Tecoma species were tested in vitro using assays against the Zika virus. Methods There was a total of 8 extracts obtained from different anatomical parts of three Tecoma species. The Tecoma castaneifolia , T. garrocha , T. stans var. angustata and T. stans var. stans were prepared by percolation with ethanol. The antiviral activity was assayed in vitro against the Zika virus by the MTT colorimetric method ( n = 3). The UPLC-DAD-MS analysis of ethanolic extracts was performed from all the studied species. The biofractionation of T. stans var. stans trunk extract using different separation techniques led to the isolation of crenatoside compound. Results Ethanolic extract from Tecoma species leaves were more active against the Zika virus (EC 50 149.90 to 61.25 μg/mL) when compared to the trunk extracts tested (EC 50 131.0 to 66.79 μg/mL and two were not active). The ethyl acetate and aqueous fractions obtained from T. stans var. stans trunk were active against the Zika virus with EC 50 values of 149.90 and 78.98 μg/mL, respectively. Crenatoside is a phenylethanoid glycoside isolated from the ethyl acetate of T. stans var. stans trunk extract. This compound was tested and exhibited EC 50 34.78 μM (21.64 μg/mL), thus demonstrating a better result than the original ethanolic extracts as well as others extracts of Tecoma species, and it was more active than the positive control, ribavirin (386.84 μM). Furthermore, its selectivity index was at least 2.5 times higher than the tested ethanolic extracts and 11.1 times more potent than ribavirin. Conclusion The Tecoma species demonstrated interesting in vitro activity against the Zika virus . The crenatoside, phenylethanoid glycoside that was for the first time isolated from Tecoma stans var. stans , exhibited a potent and relevant anti- Zika virus activity, being more active than ribavirin (positive ...

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“…Moreover, the structure–activity relationship is not yet cleary demonstrated [ 294 ]. A study on the ethanolic extract obtained from Distictella elongata and its isolated constituents, against human herpesvirus type 1 (HSV-1), murine encephalomyocarditis virus (EMCV), vaccinia virus western reserve (VACV-WR) and dengue virus 2 (DENV-2), showed that the most remarkable effect was observed for a mixture of pectolinarin with acacetin-7- O -rutinoside against DENV-2 was (EC 50 11.1 ± 1.6, CC 50 > 500 μg/ml), whereas pure pectolinarin was less active against DENV-2 (EC 50 86.4 ± 3.8, CC 50 402.6 ± 9.8 μg/ml), VACV-WR (EC 50 207.1 ± 9.6, CC 50 449.0 ± 13.0 μg/mL) and HSV-1 (EC 50 314.5 ± 22.7, CC 50 449.0 ±13.0 μg/mL) [ 295 ].…”

Section: Biological Activities Of Pectolinarin and Pectolinarigenimentioning

confidence: 99%

Isolation and Biological Properties of the Natural Flavonoids Pectolinarin and Pectolinarigenin—A Review

et al. 2020

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Flavonoids are metabolites widely distributed in plants and commonly present in foods, such as fruits and vegetables. Pectolinarin, which belongs to the flavone subclass, has attracted considerable attention due to its presence in many medicinal plants. It has turned out to be a good biological agent especially due to its antioxidant, anti-inflammatory, antidiabetic, and antitumor activities, evaluated both in vitro and in vivo. Its aglycone, the metabolite pectolinarigenin, is also known for a series of biological properties including anti-inflammatory and antidiabetic effects. In the first overview on the two metabolites here presented, their collection, isolation and the results of their biological evaluation are reported.

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Antiviral activity of Distictella elongata (Vahl) Urb. (Bignoniaceae), a potentially useful source of anti-dengue drugs from the state of Minas Gerais, Brazil

Cited by 42 publications

References 18 publications

Iridoids of Chemotaxonomy Relevance, a New Antirrhinoside Ester and Other Constituents from Kickxia spuria subsp. integrifolia (Brot.) R.Fern.

Iridoids of Chemotaxonomy Relevance, a New Antirrhinoside Ester and Other Constituents from Kickxia spuria subsp. integrifolia (Brot.) R.Fern.

Anti-Zika virus activity and chemical characterization by ultra-high performance liquid chromatography (UPLC-DAD-UV-MS) of ethanol extracts in Tecoma species

Isolation and Biological Properties of the Natural Flavonoids Pectolinarin and Pectolinarigenin—A Review

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