2006
DOI: 10.1055/s-2005-373168
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Antiviral Activity of a Carrageenan fromGigartina skottsbergiiagainst Intraperitoneal MurineHerpes simplexVirus Infection

Abstract: The partially cyclized mu/nu-carrageenan 1C3, isolated from the red seaweed Gigartina skottsbergii, was previously shown to be a potent inhibitor of the in vitro replication of Herpes simplex virus types 1 (HSV-1) and 2 (HSV-2). Here the protective effect of 1C3 in a murine model of intraperitoneal ( i. p.) HSV-1 infection was evaluated. OF1 mice were i. p. infected with 5 x 10 (5) PFU of HSV-1 KOS strain, and the effects of different treatments with 1C3 were studied. When 30 mg/kg of body weight of 1C3 was ad… Show more

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Cited by 54 publications
(29 citation statements)
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“…At present, the limitations of the available animal models of DENV infection have restricted the in vivo evaluation of compounds with in vitro proved antiviral activity. However, algal polysaccharides have shown in vivo antiviral activity against other enveloped viruses like murine leukemia virus [13], HSV [10], [14], cytomegalovirus [15] and yellow fever virus [16], warranting the future perspectives of these natural compounds for prevention against dengue. …”
Section: Resultsmentioning
confidence: 99%
“…At present, the limitations of the available animal models of DENV infection have restricted the in vivo evaluation of compounds with in vitro proved antiviral activity. However, algal polysaccharides have shown in vivo antiviral activity against other enveloped viruses like murine leukemia virus [13], HSV [10], [14], cytomegalovirus [15] and yellow fever virus [16], warranting the future perspectives of these natural compounds for prevention against dengue. …”
Section: Resultsmentioning
confidence: 99%
“…Protection was not improved when repeated hourly doses were administered at up to 48 h post infection, indicating that the substance plays a role early in the virus replication process. Indeed, treatment initiated 24 h post infection yielded no improvement compared to non-treated animals (49).…”
Section: Natural Products With Anti-herpes Simplex Virus Activitymentioning
confidence: 89%
“…There are some publications about antiviral properties of different species of marine algae such as brown, green and red algae (Damonte et al, 1996;Lopez et al, 2001;Lee et al, 2004;Serkedjieva, 2004;Richards et al, 1978;Preeprame et al, 2001;Ghosh et al, 2004;Hayashi et al, 2006;Pujol et al, 2006). In most studies done in this area, the viruses tested belonged to the herpesviridae family, especially herpes simplex viruses.…”
Section: Discussionmentioning
confidence: 99%