Antiurolithic effect of Bergenia ligulata rhizome: An explanation of the underlying mechanisms

Bashir, Samra; Gilani, Anwarul Hassan

doi:10.1016/j.jep.2008.12.004

Cited by 123 publications

(103 citation statements)

References 44 publications

(47 reference statements)

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“…Recently several plants including Herniaria hirsuta (24), Phyllanthus niruri (25) and Bergenia linguata (26) are being explored for their anti-urolithiatic properties on the basis of their usage in the traditional medicine. Herniaria hirsuta, a plant from Morocco is also known to exhibit the antilithiatic activity.…”

Section: Commentsmentioning

confidence: 99%

“…Bergenia ligulata is a widely used plant in South Asia, mainly India and Pakistan, as a traditional medicine for treatment of urolithiasis. The crude aqueous-methanolic extract of Bergenia ligulata rhizome was studied using in vitro and in vivo methods and the extract showed the antiurolithic activity through CaOx crystal inhibition, diuretic, hypermagneseuric and antioxidant effects (26). Also in our laboratory, antilithiatic potency of Dolichos biflorus (27) and Trachyspermum ammi (28) has been evaluated in vitro and in vivo.…”

Section: Commentsmentioning

confidence: 99%

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Diminution of oxalate induced renal tubular epithelial cell injury and inhibition of calcium oxalate crystallization in vitro by aqueous extract of Tribulus terrestris

Aggarwal¹,

Tandon²,

Singla

et al. 2010

Int. braz j urol.

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Purpose: Recurrence and persistent side effects of present day treatment for urolithiasis restrict their use, so an alternate solution, using phytotherapy is being sought. The present study attempted to evaluate the antilithiatic properties of Tribulus terrestris commonly called as "gokhru" which is often used in ayurveda to treat various urinary diseases including urolithiasis. Materials and Methods:The activity of Tribulus terrestris was investigated on nucleation and the growth of the calcium oxalate (CaOx) crystals as well as on oxalate induced cell injury of NRK 52E renal epithelial cells. Results: Tribulus terrestris extract exhibited a concentration dependent inhibition of nucleation and the growth of CaOx crystals. When NRK-52E cells were injured by exposure to oxalate for 72 h, Tribulus terrestris extract prevented the injury in a dose-dependent manner. On treatment with the different concentrations of the plant, the cell viability increased and lactate dehydrogenase release decreased in a concentration dependent manner. Conclusion: The current data suggests that Tribulus terrestris extract not only has a potential to inhibit nucleation and the growth of the CaOx crystals but also has a cytoprotective role. Our results indicate that it could be a potential candidate for phytotherapy against urolithiasis.

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Section: Commentsmentioning

confidence: 99%

Section: Commentsmentioning

confidence: 99%

Diminution of oxalate induced renal tubular epithelial cell injury and inhibition of calcium oxalate crystallization in vitro by aqueous extract of Tribulus terrestris

Aggarwal¹,

Tandon²,

Singla

et al. 2010

Int. braz j urol.

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“…A titre d'exemple, les diurétiques, les anti-inflammatoires et les inhibiteurs de certains métabolites sont les seuls médicaments utilisés dans le traitement de la lithiase oxalocalcique, avec des effets secondaires inévitables (Chagnon 2007). Plusieurs plantes ont fait l'objet de recherches scientifiques en Algérie et à travers le monde pour évaluer l'activité antilithiasique dans un système in vitro et in vivo telles que Bergenia ligulata Engl., Tamarix gallica L., Punica granatum L., Cynodon dactylon (L.) Pers., Matricaria chamomilla L. (Bashir & Gilani 2009, Bensatal & Ouahrani 2008, Sekkoum et al 2010.…”

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Plantes antilithiasiques utilisées en médecine traditionnelle dans la ville d’Oran, Algérie

Khitri¹,

Lachgueur²,

Tasfaout³

et al. 2016

ethnoecologie

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“…Bashir & Gilani (2009) Rubus idaeus é amplamente distribuída nos países mediterrâneos. Ghalayini et al (2011) avaliaram extrato aquoso a 11,5%, por 12 dias, em ratos com hiperoxalúria induzida por etileno glicol.…”

Section: Principais Plantas Medicinais Com Potencial Uso No Controle unclassified

Plantas medicinais no controle de urolitíase

Cruces

Patelli

Tashima

et al. 2013

Rev. bras. plantas med.

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Norte do Paraná (UENP/Bandeirantes).RESUMO: Plantas medicinais têm sido utilizadas mundialmente para o controle de urolitíases na medicina humana. A ocorrência desta afecção tem aumentado em humanos, ruminantes, cães e gatos. Nos animais, fatores patofisiológicos adquiridos, congênitos ou familiares podem estar envolvidos, havendo similaridade ao que se observa em seres humanos. Porém, apesar dos avanços nas pesquisas, o emprego de plantas medicinais na medicina veterinária, ainda é pouco utilizado. Dessa forma, objetivou-se apresentar uma revisão bibliográfica dos resultados do uso de plantas medicinais no controle de urolitíase. As plantas utilizadas são: Ammi visnaga, Bergenia ligulata, Cynodon dactylon, Herniaria hirsuta e Phyllanthus niruri. A atividade antilitogênica foi relacionada às alterações da composição iônica da urina, atividade diurética, inibição de cristalização e agregação de cristais. Destaca-se o uso de Phyllanthus niruri, pela eficácia na prevenção dos urólitos. Extratos de Phyllanthus niruri normalizaram níveis altos de cálcio urinário, desfavorecendo os estágios iniciais de formação dos urólitos. Adicionalmente, foram associados à elevação da filtração glomerular e excreção urinária de ácido úrico sugerindo utilização potencial não só como efeito lítico e preventivo das calculoses, mas também em pacientes hiperuricêmicos e portadores de insuficiência renal. A partir dos resultados relatados, pode-se concluir que os trabalhos apresentados pela literatura atual são capazes de comprovar os efeitos benéficos do uso de plantas medicinais no controle de urolitíase. Entretanto, ainda são escassos os estudos realizados em animais domésticos, predominando ensaios desenvolvidos em roedores. Palavras-chave: ervas medicinais, Phyllanthus niruri, urina, urólitos.ABSTRACT: Using medicinal plants in the control of urolithiasis. Medicinal plants have been used worldwide in the prevention of urolithiasis. The occurrence of this disease has increased in men, ruminants, dogs and cats. With regard to animals, acquired (congenital or hereditary) pathophysiological factors may be involved, a fact that bears similarity to what has been observed in humans. Yet, despite advances in research, the use of medicinal plants in veterinary medicine remains still underutilized. Thus, the purpose of this study is to conduct a literature review on the use of medicinal plants in the control of urolithiasis. The plants used are: Ammi visnaga, Bergenia ligulata, Cynodon dactylon, Herniaria hirsute and Phyllanthus niruri. Antilithogenic activity was related to changes in the ionic composition of urine, diuretic activity and inhibition of crystallization and aggregation of crystals. It is worth highlighting the use of Phyllanthus niruri due to its efficiency in the prevention of uroliths. Phyllanthus niruri extracts normalized high levels of urinary calcium, inhibiting the formation of uroliths in the initial stages. Additionally, they were associated with a higher glomerular filtration and higher urinary excretion of uric acid....

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Antiurolithic effect of Bergenia ligulata rhizome: An explanation of the underlying mechanisms

Cited by 123 publications

References 44 publications

Diminution of oxalate induced renal tubular epithelial cell injury and inhibition of calcium oxalate crystallization in vitro by aqueous extract of Tribulus terrestris

Diminution of oxalate induced renal tubular epithelial cell injury and inhibition of calcium oxalate crystallization in vitro by aqueous extract of Tribulus terrestris

Plantes antilithiasiques utilisées en médecine traditionnelle dans la ville d’Oran, Algérie

Plantas medicinais no controle de urolitíase

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