Antitumour effect of fibrinogen microspheres containing doxorubicin on Ehrlich ascites carcinoma

Abstract

The antitumour activity of fibrinogen microspheres containing doxorubicin has been evaluated against Ehrlich ascites carcinoma in mice in terms of changes in body weight and survival. Tumour cell injections were made on day 0 and microsphere injections on day 1, both intraperitoneally. The suppressive effect of the drug-containing microspheres on increase in body weight was higher than that of the free drug, and tumour-bearing mice given the microspheres lived longer than those given the free drug.

Anti-Tumor Effect of Mitoxantrone-Loaded Bovine Casein Microspheres on Ehrlich Ascites Carcinoma in Mice

“…There are few reports in the literature on the antitumor activity of antineoplastic agents containing microsphere formulations against EAC. Miyazaki et al [16] investigated the antitumor effect of doxorubicin containing fibrinogen microspheres and Sugibayashi et al [17] and Morimoto et al [18] investigated the antitumor effect of 5-fluorouracil-entrapped albumin microspheres on EAC. Doxorubicin has antitumor activity comparable with mitoxantrone.…”

Fibrinogen as a promising material for various biomedical applications

“…For the incorporation of drugs into Fbg microspheres, the drug solution can be added to the W/O emulsion before adding an emulsifier. Using this method, some anti-cancer drugs, such as 5-fluorouracil 38 and adriamycin 39,40 , have been encapsulated, suggesting further applications in other drug incorporation studies. In our previous study, Fbg microspheres were similarly developed using the W/O emulsification method, with the exception of the solvent being evaporated by adding acetone instead of the use of pre-heated oil in order to decrease protein denaturation 17 .…”