Biodegradation and antitumour effect of adriamycin-containing poly(l-lactic acid) microspheres

Ike, Osamu; Shimizu, Yasuhiko; Ikada, Yoshito; Watanabe, Satoshi; Natsume, Tohru; Wada, Ryoichi; Hyon, Suong‐Hyu; Hitomï, Shigeki

doi:10.1016/0142-9612(91)90026-7

Cited by 23 publications

(12 citation statements)

References 11 publications

Supporting

Mentioning

Contrasting

Unclassified

Order By: Relevance

“…• DOX-loaded microparticles [25][26][27] • PLGA NPs [28][29][30][31] • PLGA-PEG micelles [28][29][30][31] • PLGA-vitamin E tocopheryl polyethylene glycol succinate NPs with DOX covalently conjugated to the PLGA polymer [28][29][30][31] • pH-sensitive DOX-loaded micelles of poly(Lhistidine)-PEG-folate and PLA-PEG-folate blends [32] • Self-assembled NPs of PLGA-g-pullulan loaded with DOX [33], among others • Multifunctional micelles of PLA-PEG loaded with superparamagnetic iron oxide NPs and DOX [34] Microparticle formulations have limited clinical potential since they must be locally administered or implanted. Formulations in which DOX is chemically conjugated to the drug carrier are often problematic because modification of the drug may lead to changes in its in vivo activity and creates the risk for creation of nonbiocompatible products of drug-polymer metabolism.…”

mentioning

confidence: 99%

Doxorubicin-Loaded PLGA Nanoparticles by Nanoprecipitation: Preparation, Characterization and In Vitro Evaluation

2007

View full text Add to dashboard Cite

show abstract

mentioning

confidence: 99%

Doxorubicin-Loaded PLGA Nanoparticles by Nanoprecipitation: Preparation, Characterization and In Vitro Evaluation

2007

View full text Add to dashboard Cite

show abstract

“…Poly(D,L-lactide-co-glycolide) (PLGA) has been previously used to prepare microspheres encapsulated with various molecules for the purpose of brain implantation (Ike et al 1991, Menei et al 1993. The biodegradation and tissue reaction of the copolymer PLGA microspheres, which were prepared by the solvent evaporation method, radiosterilized, and stereotactically implanted in the rat brain, have been studied by routine tissue staining, immunohistochemistry, and transmission electron microscopy (Menei et al 1993;Splenlehauer et al 1991).…”

mentioning

confidence: 99%

Adsorption of Brain Proteins on the Surface of Poly (D,L-lactide-co-glycolide) (PLGA) Microspheres

1997

View full text Add to dashboard Cite

Poly(D,L-lactide-co-glycolide) (PLGA) microspheres have been studied for intracerebral delivery of anticancer agents. To explore the biocompatibility nature of the polymer in brain, we have investigated the adsorption of brain proteins on the surfaces of PLGA microspheres. Microspheres were made by the solvent evaporation method using an oivwater (o/w) system. The brain protein adsorption experiment was performed by using a sonication eluting method. Sodium dodecyl sulfate-polyacrylamide gel electrophoresis (SDS-PAGE) was used to examine the brain proteins adsorbed. Ethyl cellulose microspheres were used in the study as a reference. The amount of brain proteins adsorbed on PLGA microspheres was also determined using a radiolabeling technique. The extent of brain proteins adsorbed on the PLGA microspheres was found to be lower than that adsorbed on the ethyl cellulose microspheres. The adsorption of brain proteins on PLGA microspheres, however, was significant, as indicated quantitatively by the lZ5I labeling studies. The adsorption of brain proteins on the surface of the PLGA microspheres may be important when considering the use of this polymer as a brain implant delivery system.

show abstract

“…Son varios los trabajos reportados acerca de la liberación de diversos medicamentos como los anticancerígenos (9)(10)(11)(12)(13)(14)(15)(16)(17)(18) y antibióticos (19)(20)(21)(22) incluyendo el estudio de los biomateriales en los cuales están soportadas dichas drogas.…”

Section: Diferentes Tipos De Sistemas (Biomateria-droga)unclassified

Sistemas biomaterial-droga para la liberación controlada de antibióticos

Grenier¹,

González²

1994

biomedica

View full text Add to dashboard Cite

RESUMENEn el presente trabajo se recogen las principales características de los sistemas de liberación sostenidade medicamentossoportadosen diferentes biomateriales y que son utilizados fundamentalmente en el tratamiento de lesiones óseas. Sobre la base de una revisión bibliográfica actualizada en este tema, se analizan en detalle los tipos de biomateriales más utilizados, así como las ventajas y desventajas que los mismos presentan en tal aplicación. SUMMARYThe purpose of this paper was to review the main characteristics of a drug delivery System supported on different biomaterials and particularly the systerns applied on the treatmet of bone diseases. The advantages and disadvantages of thistype of biomaterial utilised with this objective are analysed in detail, based on the study of up-to-date literature in this area.Actualmente, la administración local de medicamentos ha despertado gran atención debido a que constituye un método seguro y eficiente mediante el cual se obtienen efectos quimioterapéuticos superiores.En el-caso del uso local de antibióticos, se cuenta con varias formas de aplicación como son por ejemplo: el método de irrigación-succión encerrada (1.2); perfusión regional de un miembro (3); bombasdeantibióticos implantables (4), y más recientemente sistemas de liberación usando materiales que pueden retener el medicamento.Los sistemas de liberación controlada de medicamentos fueron concebidos debido a la necesidad de unaterapia local y actualmentevan adquiriendo cada vez más importancia debido a las diversas ventajas que presentan. Entre tales ventajas se encuentran las siguientes:Se logra una administración local de la droga.La acción de la droga es más efectiva, ya que a diferencia de la administración por vía oral o por perfusión, los virus u organismos extraños son atacados directamente. Evita segundas intervencionesSe logra un mayor control de la enfermedad en cuestión. traciones del medicamento por vía sistémica.

show abstract

Biodegradation and antitumour effect of adriamycin-containing poly(l-lactic acid) microspheres

Cited by 23 publications

References 11 publications

Doxorubicin-Loaded PLGA Nanoparticles by Nanoprecipitation: Preparation, Characterization and In Vitro Evaluation

Doxorubicin-Loaded PLGA Nanoparticles by Nanoprecipitation: Preparation, Characterization and In Vitro Evaluation

Adsorption of Brain Proteins on the Surface of Poly (D,L-lactide-co-glycolide) (PLGA) Microspheres

Sistemas biomaterial-droga para la liberación controlada de antibióticos

Contact Info

Product

Resources

About