Fibrinogen as a promising material for various biomedical applications

Joo, Jae Yeon; Amin, Md. Lutful; Rajangam, Thanavel; An, Seong Soo A.

doi:10.1007/s13273-015-0001-y

Cited by 16 publications

(13 citation statements)

References 64 publications

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“…Additionally, combinations thereof may be used in order to obtain end-use-specific properties. Thus, hydrogels based on different natural polymers (alginate [ 10 , 11 ], gelatin [ 12 , 13 ], cellulose [ 14 , 15 ], collagen [ 16 , 17 , 18 ], fibrinogen [ 19 , 20 ], hyaluronic acid [ 21 , 22 , 23 ]) or synthetic polymers (such as polyacrylamide [ 24 , 25 ], polyurethane [ 26 , 27 , 28 , 29 ], poly-(ethylene glycol) [ 30 , 31 ]) have been explored for the development of biomaterial inks. Naturally sourced bioactive polymers demonstrate superior biofunctionality over synthetic ones.…”

Section: Introductionmentioning

confidence: 99%

Assessment of Naturally Sourced Mineral Clays for the 3D Printing of Biopolymer-Based Nanocomposite Inks

et al. 2021

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The present study investigated the possibility of obtaining 3D printed composite constructs using biomaterial-based nanocomposite inks. The biopolymeric matrix consisted of methacrylated gelatin (GelMA). Several types of nanoclay were added as the inorganic component. Our aim was to investigate the influence of clay type on the rheological behavior of ink formulations and to determine the morphological and structural properties of the resulting crosslinked hydrogel-based nanomaterials. Moreover, through the inclusion of nanoclays, our goal was to improve the printability and shape fidelity of nanocomposite scaffolds. The viscosity of all ink formulations was greater in the presence of inorganic nanoparticles as shear thinning occurred with increased shear rate. Hydrogel nanocomposites presented predominantly elastic rather than viscous behavior as the materials were crosslinked which led to improved mechanical properties. The inclusion of nanoclays in the biopolymeric matrix limited hydrogel swelling due the physical barrier effect but also because of the supplementary crosslinks induced by the clay layers. The distribution of inorganic filler within the GelMA-based hydrogels led to higher porosities as a consequence of their interaction with the biopolymeric ink. The present study could be useful for the development of soft nanomaterials foreseen for the additive manufacturing of customized implants for tissue engineering.

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Section: Introductionmentioning

confidence: 99%

Assessment of Naturally Sourced Mineral Clays for the 3D Printing of Biopolymer-Based Nanocomposite Inks

et al. 2021

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“…[2,3] Nanofibrous fibrinogen scaffolds in particular offer very promising strategies for regenerative medicine as they mimic the nanoarchitecture of native blood clots and contain important binding sites to support cell adhesion. [3,4] Hence, they can serve as a provisional extracellular matrix (ECM) during the initial wound healing phase and were even found to have immunomodulatory properties. [5][6][7][8] Interestingly, it is known that mutations or structural changes in fibrinogen can induce thrombosis.…”

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confidence: 99%

Principles of Fibrinogen Fiber Assembly In Vitro

Stamboroski

Joshi

Noeske

et al. 2021

Macromolecular Bioscience

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Fibrinogen nanofibers hold great potential for applications in wound healing and personalized regenerative medicine due to their ability to mimic the native blood clot architecture. Although versatile strategies exist to induce fibrillogenesis of fibrinogen in vitro, little is known about the underlying mechanisms and the associated length scales. Therefore, in this manuscript the current state of research on fibrinogen fibrillogenesis in vitro is reviewed. For the first time, the manifold factors leading to the assembly of fibrinogen molecules into fibers are categorized considering three main groups: substrate interactions, denaturing and non‐denaturing buffer conditions. Based on the meta‐analysis in the review it is concluded that the assembly of fibrinogen is driven by several mechanisms across different length scales. In these processes, certain buffer conditions, in particular the presence of salts, play a predominant role during fibrinogen self‐assembly compared to the surface chemistry of the substrate material. Yet, to tailor fibrous fibrinogen scaffolds with defined structure–function‐relationships for future tissue engineering applications, it still needs to be understood which particular role each of these factors plays during fiber assembly. Therefore, the future combination of experimental and simulation studies is proposed to understand the intermolecular interactions of fibrinogen, which induce the assembly of soluble fibrinogen into solid fibers.

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“…Silk fibroin has been the most common material to address the solution within this approach [ 57 , 60 , 66 , 75 ]. It is a biocompatible material that has good mechanical properties than can be tuned with the manufacturing process.…”

Section: Discussionmentioning

confidence: 99%

“…A bioactive vascular graft has been constructed by blending fibrinogen with gelatin. Fibrinogen does not have the rheological properties to be printed with the DIW technique (viscosity < 0.5 Pa·s), but it is a favorable biomaterial for vascular tissue engineering [ 66 ]. They performed a heat treatment on the gelatin, to reduce its molecular weight, and then it was mixed with fibrinogen.…”

Section: Cardiovascular Tubular Applicationsmentioning

confidence: 99%

Continuous Based Direct Ink Write for Tubular Cardiovascular Medical Devices

2020

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Bioresorbable cardiovascular applications are increasing in demand as fixed medical devices cause episodes of late restenosis. The autologous treatment is, so far, the gold standard for vascular grafts due to the similarities to the replaced tissue. Thus, the possibility of customizing each application to its end user is ideal for treating pathologies within a dynamic system that receives constant stimuli, such as the cardiovascular system. Direct Ink Writing (DIW) is increasingly utilized for biomedical purposes because it can create composite bioinks by combining polymers and materials from other domains to create DIW-printable materials that provide characteristics of interest, such as anticoagulation, mechanical resistance, or radiopacity. In addition, bioinks can be tailored to encounter the optimal rheological properties for the DIW purpose. This review delves into a novel emerging field of cardiovascular medical applications, where this technology is applied in the tubular 3D printing approach. Cardiovascular stents and vascular grafts manufactured with this new technology are reviewed. The advantages and limitations of blending inks with cells, composite materials, or drugs are highlighted. Furthermore, the printing parameters and the different possibilities of designing these medical applications have been explored.

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Fibrinogen as a promising material for various biomedical applications

Cited by 16 publications

References 64 publications

Assessment of Naturally Sourced Mineral Clays for the 3D Printing of Biopolymer-Based Nanocomposite Inks

Assessment of Naturally Sourced Mineral Clays for the 3D Printing of Biopolymer-Based Nanocomposite Inks

Principles of Fibrinogen Fiber Assembly In Vitro

Continuous Based Direct Ink Write for Tubular Cardiovascular Medical Devices

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