Antitumor Therapy Using Nanomaterial-Mediated Thermolysis

Sawdon, Alicia J.; Weydemeyer, Ethan; Peng, Ching‐An

doi:10.1166/jbn.2014.1917

Cited by 13 publications

(8 citation statements)

References 170 publications

(227 reference statements)

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“…[1][2][3] This approach involves targeting magnetic nanoparticles to tumors and then inducing cytotoxic hyperthermia by applying an alternating magnetic field (AMF). Iron oxide nanoparticles are optimal for inducing hyperthermia, and their effectiveness as a cancer therapeutic should be evaluated according to the following criteria: 1) they should selectively target tumor cells, 2) they should easily penetrate tumor cells, 3) they should be internalized by tumor cells, 4) they should be biocompatible and nontoxic across a wide range of concentrations, 5) they should be easy to administer in the clinic, 6) they should be likely to be approved for clinical use, and 7) they should be targetable to specific tumor types or to organs with metastases.…”

Section: Introductionmentioning

confidence: 99%

Human mesenchymal stem cell-derived iron oxide exosomes allow targeted ablation of tumor cells via magnetic hyperthermia

Altanerova¹,

Babincová²,

Babinec³

et al. 2017

IJN

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Magnetic hyperthermia, or the heating of tissues using magnetic materials, is a promising approach for treating cancer. We found that human mesenchymal stem cells (MSCs) isolated from various tissues and MSCs expressing the yeast cytosine deaminase∷uracil phosphoribosyl transferase suicide fusion gene ( yCD∷UPRT ) can be labeled with Venofer, an iron oxide carbohydrate nanoparticle. Venofer labeling did not affect cell proliferation or the ability to home to tumors. All Venofer-labeled MSCs released exosomes that contained iron oxide. Furthermore, these exosomes were efficiently endocytosed by tumor cells. Exosomes from Venofer-labeled MSCs expressing the yCD∷UPRT gene in the presence of the prodrug 5-fluorocytosine inhibited tumor growth in a dose-dependent fashion. The treated tumor cells were also effectively ablated following induction of hyperthermia using an external alternating magnetic field. Cumulatively, we found that magnetic nanoparticles packaged into MSC exosomes are efficiently endocytosed by tumor cells, facilitating targeted tumor cell ablation via magnetically induced hyperthermia.

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Section: Introductionmentioning

confidence: 99%

Human mesenchymal stem cell-derived iron oxide exosomes allow targeted ablation of tumor cells via magnetic hyperthermia

Altanerova¹,

Babincová²,

Babinec³

et al. 2017

IJN

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“…Superparamagnetic iron oxide MNPs (magnetite, Fe 3 O 4 and maghemite, γ-Fe 2 O 3 ) have been used in numerous applications in biomedicine, such as magnetic resonance imaging (MRI) [ 6 ], drug delivery [ 7 ], and thermoablation therapy [ 8 ]. IONPs can be coated with hydrophilic layers followed by subsequent conjugation of target specific proteins (peptides, antigens and antibodies), which add much needed biocompatibility and target specificity [ 9 ].…”

Section: Introductionmentioning

confidence: 99%

In Vitro/In Vivo Toxicity Evaluation and Quantification of Iron Oxide Nanoparticles

Patil

Adireddy

Jaiswal

et al. 2015

IJMS

171

117

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Increasing biomedical applications of iron oxide nanoparticles (IONPs) in academic and commercial settings have alarmed the scientific community about the safety and assessment of toxicity profiles of IONPs. The great amount of diversity found in the cytotoxic measurements of IONPs points toward the necessity of careful characterization and quantification of IONPs. The present document discusses the major developments related to in vitro and in vivo toxicity assessment of IONPs and its relationship with the physicochemical parameters of IONPs. Major discussion is included on the current spectrophotometric and imaging based techniques used for quantifying, and studying the clearance and biodistribution of IONPs. Several invasive and non-invasive quantification techniques along with the pitfalls are discussed in detail. Finally, critical guidelines are provided to optimize the design of IONPs to minimize the toxicity.

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“…It has been shown that using biodegradable polymeric and magnetic nanoparticles as gene delivery carriers could promote macrophage phagocytosis and activate CD8 + T cell reaction [15]. SPION is one of the most popular nano-carriers for gene delivery due to its high surface-to-volume ratio and specific magneticity [16][17][18]. In addition, the SPION-PEI had a low cytotoxicity [19].…”

Section: Discussionmentioning

confidence: 99%

Intranasal delivery of plasmids expressing bovine herpesvirus 1 gB/gC/gD proteins by polyethyleneimine magnetic beads activates long-term immune responses in mice

Liu

Guo-wei

Gao

et al. 2021

Virol J

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Background DNA vaccine is one of the research hotspots in veterinary vaccine development. Several advantages, such as cost-effectiveness, ease of design and production, good biocompatibility of plasmid DNA, attractive biosafety, and DNA stability, are found in DNA vaccines. Methods In this study, the plasmids expressing bovine herpesvirus 1 (BoHV-1) gB, gC, and gD proteins were mixed at the same mass ratio and adsorbed polyethyleneimine (PEI) magnetic beads with a diameter of 50 nm. Further, the plasmid and PEI magnetic bead polymers were packaged into double carboxyl polyethylene glycol (PEG) 600 to use as a DNA vaccine. The prepared DNA vaccine was employed to vaccinate mice via the intranasal route. The immune responses were evaluated in mice after vaccination. Results The expression of viral proteins could be largely detected in the lung and rarely in the spleen of mice subjected to a vaccination. The examination of biochemical indicators, anal temperature, and histology indicated that the DNA vaccine was safe in vivo. However, short-time toxicity was observed. The total antibody detected with ELISA in vaccinated mice showed a higher level than PBS, DNA, PEI + DNA, and PBS groups. The antibody level was significantly elevated at the 15th week and started to decrease since the 17th week. The neutralizing antibody titer was significantly higher in DNA vaccine than naked DNA vaccinated animals. The total IgA level was much greater in the DNA vaccine group compared to other component vaccinated groups. The examination of cellular cytokines and the percentage of CD4/CD8 indicated that the prepared DNA vaccine induced a strong cellular immunity. Conclusion The mixed application of plasmids expressing BoHV-1 gB/gC/gD proteins by nano-carrier through intranasal route could effectively activate long-term humoral, cellular, and mucosal immune responses at high levels in mice. These data indicate PEI magnetic beads combining with PEG600 are an efficient vector for plasmid DNA to deliver intranasally as a DNA vaccine candidate.

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Antitumor Therapy Using Nanomaterial-Mediated Thermolysis

Cited by 13 publications

References 170 publications

Human mesenchymal stem cell-derived iron oxide exosomes allow targeted ablation of tumor cells via magnetic hyperthermia

Human mesenchymal stem cell-derived iron oxide exosomes allow targeted ablation of tumor cells via magnetic hyperthermia

In Vitro/In Vivo Toxicity Evaluation and Quantification of Iron Oxide Nanoparticles

Intranasal delivery of plasmids expressing bovine herpesvirus 1 gB/gC/gD proteins by polyethyleneimine magnetic beads activates long-term immune responses in mice

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