Antitumor and immunomodulatory activity of arabinoxylans: A major constituent of wheat bran

Cao, Li; Liu, Xiuzhen; Qian, Tianxiu; Sun, Guibo; Guo, Yan; Chang, Fengjin; Zhou, Sumei; Sun, Xiaobo

doi:10.1016/j.ijbiomac.2010.10.014

Cited by 99 publications

(90 citation statements)

References 19 publications

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“…The similar enhanced immune response in various animals, by plant extracts, was reported in previous studies (Akhtar et al, 2012;Nandini et al, 2016). Likewise, different plant extracts have been reported to increase spleenocytes proliferation, delayed type of hypersensitivity reaction and phagocytic activity of macrophages in experimental animals (Cao et al, 2010). Similarly, G. glabra (Glycyrrhizin) extract is used in autoimmune conditions and has therapeutic benefit in immunodeficiency conditions like AIDS (Mazumder et al, 2012).…”

Section: Discussionmentioning

confidence: 99%

Immunomodulatory Activity of Glycyrrhiza glabra Extract against Mixed Eimeria Infection in Chickens

Hussain¹

2017

IJAB

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This study was conducted to evaluate the immunomodulatory activity of aqueous methanolic extract (AME) of Glycyrrhiza glabra (roots) against mixed Eimeria species infection in broiler chickens. For in vivo trial, 175 day old broiler chicks were divided into five equal groups (A, B, C, D and E). At one week of age, groups A, B and C were given orally three graded doses of G. glabra AME (100, 200 and 300 mg/kg of body weight respectively) for three consecutive days. Group D served as positive (Vitamin E treated) and Group E as negative control (PBS treated). At 14 th day of age, all groups were infected orally with 60,000 sporulated oocysts of mixed Eimeria species. Cell mediated immune response was evaluated by four tests (Phytohemagglutinin-P, Concanavalin-A, Carbon clearance assay and Dinitrochlorobenzene). Humoral immune response was evaluated by microplate hemagglutination test using sheep red blood cells. Results revealed a dose dependent immune response in G. glabra AME treated groups. Cell mediated and humoral immune response of group treated with G. glabra AME @ 300 mg/kg of body weight was almost similar (P˃0.05) to the positive control group (Vitamin E treated). G. glabra AME treated groups showed significantly higher (P<0.05) cell mediated and humoral response as compared to negative control (PBS treated).

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Section: Discussionmentioning

confidence: 99%

Immunomodulatory Activity of Glycyrrhiza glabra Extract against Mixed Eimeria Infection in Chickens

Hussain¹

2017

IJAB

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“…The immune response including both cellular and humoral immunity, response by T cells and B cells respectively, plays an important role in the host defense system, which is in connection with almost all the situations of body such as tumor, inflammation, rheum, fever even sternutation [21,22]. The capacity to elicit an effective T and B cells immunity can be shown by the stimulation of lymphocyte proliferation response [23]. The present assay showed that LBP-IV could significantly promote the ConA or LPS stimulated splenocyte proliferation.…”

Section: Splenocyte Proliferation Activity Of Lbp-ivmentioning

confidence: 99%

Polysaccharides from Lycium barbarum leaves: Isolation, characterization and splenocyte proliferation activity

Liu¹,

Fan²,

Wang³

et al. 2012

International Journal of Biological Macromolecules

112

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“…Los AX también estimulan un aumento en los niveles de IL-2, pudiendo estar relacionado con ciertas propiedades antitumorales (Cao et al, 2011). Además, los AX estimulan la respuesta de anticuerpos, aumentando los niveles de IgG e IgM plasmáticos (Akhtar et al, 2012).…”

Section: Efectos Inmunomoduladoresunclassified

Arabinoxilanos y su importancia en la salud

Mulero

2017

Revista Complutense De Ciencias Veterinarias

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Revista Complutense de Ciencias Veterinarias 2017 11(especial):84-89 ARABINOXILANOS Y SU IMPORTANCIA EN LA SALUD TARABINOXYLANS AND THEIR HEALTH EFFECTS Ciudad-Mulero, MaríaDpto. Nutrición y Bromatología II. Facultad de Farmacia, Universidad Complutense de Madrid, Madrid, España. mariaciudad@ucm.es RESUMENLos arabinoxilanos (AX) son los principales polisacáridos no celulósicos en los cereales y forman parte de la fracción soluble de la fibra dietética. Estos compuestos ejercen efectos importantes sobre la salud, siendo el efecto prebiótico uno de los más destacados, el cual, junto con la capacidad antioxidante que han demostrado, convierten a estassustancias en agentes de prevención frente al cáncer de colon.A nivel metabólico los AX actúan como reguladores de la glucemia y del colesterol plasmático, siendo, además, agentes inmunomoduladores. En los últimos años el estudio de los AX ha despertado gran interés puesto que han demostrado tener importantes funciones a nivel fisiológico, funcional y tecnológico. Palabras clave: arabinoxilanos, arabinoxilooligosacáridos, prebióticos, antioxidante ABSTRACTThe arabinoxylans (AX) are the main non cellulosic polysaccharides in cereals being part of the soluble fraction of the dietary fiber. These compounds have important and numerous health benefits. One of the most noteworthy health benefits is their prebiotic effect jointly with their proven antioxidant ability makes these compounds prevention agents of colon cancer diseases. At the metabolic level the AX control glycemic and cholesterol levels being Ciudad-Mulero, M. Revista Complutense de Ciencias Veterinarias 11 (especial) 2017: 84-89 also immunoregulator agents. During the later years the research and interest of the AX has gather considerable attention since they have been related to important functions such as functional, physiological as well as technological.

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Antitumor and immunomodulatory activity of arabinoxylans: A major constituent of wheat bran

Cited by 99 publications

References 19 publications

Immunomodulatory Activity of Glycyrrhiza glabra Extract against Mixed Eimeria Infection in Chickens

Immunomodulatory Activity of Glycyrrhiza glabra Extract against Mixed Eimeria Infection in Chickens

Polysaccharides from Lycium barbarum leaves: Isolation, characterization and splenocyte proliferation activity

Arabinoxilanos y su importancia en la salud

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