Antitumor and Cytotoxic Activity of Tylopilan, a Fungal Polysaccharide from<i>Tylopilus felleus</i>Fruit Bodies

Polysaccharide fractions TG-1 and TG-2 were isolated from the fruit bodies of Trarnetes gibbosa (Pers.: Fr.) Fr.(Polyporaceae). Both fractions are glucans with trace amounts of other sugars. The polysaccharide fractions administered to rats intravenously, strongly inhibited vessel permeability in the rat pleural exudate model, induced by carragenan, but did not influence its density. Both polysaccharide fractions decreased considerably the total protein level in the pleural effusion. Fractions TG-1 and TG-2 antagonized effectively the inflammation mediator complex induced by carragenan and they neutralized the pharmacological effects with respect to small vessel permeability. At the same time they increased the number of neutrophils and eosinophils and decreased the number of lymphocytes in the peripheral blood. The pharmacological activity of polysaccharide fractions TG-1 and TG-2 confirms their function as potential factors responsible for the stabilization of a wall vessel, especially in pathological conditions leading to endothelial damage.

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“…(Kohlmunzer et a f . , 1980;Grzybek and Kohlmiinzer 1983;Defaye et al, 1988;Grzybek et al, 1990a, 1990b.…”

Section: Introductionunclassified

Antiinflammatory and vasoprotective activities of polysaccharides isolated from fruit bodies of higher Fungi P.1. polysaccharides from Trametes gibbosa (Pers.: Fr)Fr. (Polyporaceae)

Czarnecki

Grzybek

1995

Phytotherapy Research

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Antitumor and Immunomodulatory Activities of Mushroom Polysaccharides

Ooi

2008

Mushrooms as Functional Foods

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Medicinal properties of macrofungi

Hilszczańska¹

2012

Forest Research Papers

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This review highlights the importance to people of some types of wild fungi considered in the context of non-wood forest products. Macrofungi are used both for food and medicine proposes. Substances isolated from the higher Basidiomycetes and Ascomycetes mushrooms express promising immune modulating, antitumor, antiviral, antibacterial and antidiabetic properties. They have been, and are presently, used against cancer in some countries in Far East as well as in the United States of America and Canada. Their useful properties are mainly conferred by biologically-active polysaccharides present in the fruiting bodies and cultured mycelium. A few dozen different polysaccharide antitumor agents have been developed from such species as: Ganoderma lucidum, Lentinus edodes, Schizophylum commune, Trametes versicolor and Inonotus obliquus. In the review some other fungi and their properties are also described. The information is provided to widen our knowledge of the importance of the organisms that live in forest ecosystems.

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Antitumor and Cytotoxic Activity of Tylopilan, a Fungal Polysaccharide fromTylopilus felleusFruit Bodies

Abstract: Tylopilan (1) is a branched, tetrameric /-D-glucan, Mr = 1.3 x 106, isolated (1) from fruit bodies of Tylopilusfelleus (Bull. ex Fr.) P. Karst. (Boletaceae). The chemical structure of tylopilan was established by Defaye et al. (2).

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Antiinflammatory and vasoprotective activities of polysaccharides isolated from fruit bodies of higher Fungi P.1. polysaccharides from Trametes gibbosa (Pers.: Fr)Fr. (Polyporaceae)

Antiinflammatory and vasoprotective activities of polysaccharides isolated from fruit bodies of higher Fungi P.1. polysaccharides from Trametes gibbosa (Pers.: Fr)Fr. (Polyporaceae)

Antitumor and Immunomodulatory Activities of Mushroom Polysaccharides

Medicinal properties of macrofungi

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