Antitumor activity of caffeic acid 3,4-dihydroxyphenethyl ester and its pharmacokinetic and metabolic properties

In-vitro and in-vivo antimalarial activity of caffeic acid and some of its derivatives

“…Furthermore, it has been shown previously that caffeic is absorbed in rats and has an absolute bioavailability in humans around 95% . To the best of our knowledge, there are no data available about caffeic acid ethyl ester bioavailability, but a publication showed that caffeic acid phenetyl ester was resorbed in rats . Caffeic acid and derivatives could then explain, at least in part, the oral antimalarial activity of traditional medicinal plants where these compounds are abundant.…”

“…[22,23] To the best of our knowledge, there are no data available about caffeic acid ethyl ester bioavailability, but a publication showed that caffeic acid phenetyl ester was resorbed in rats. [24] Caffeic acid and derivatives could then explain, at least in part, the oral antimalarial activity of traditional medicinal plants where these compounds are abundant. One hypothesis for better activity of ethyl caffeate compared to caffeic acid could be the ability to reach intracellular targets which Figure 2 In-vivo antimalarial activity of ethyl caffeate at day 4, following the standard test of Peters, using intra-peritoneal route.…”

3,4-Dihydroxyphenylethanol alleviates early brain injury by modulating oxidative stress and Akt and nuclear factor-κB pathways in a rat model of subarachnoid hemorrhage

“…The phenolic compound 3,4-dihydroxyphenylethanol (DOPET), also known as hydroxytyrosol, a natural compound that can be extracted from olives, has numerous biological and pharmacological activities; studies conducted in recent years have confirmed that hydroxytyrosol has strong antioxidant activity, promotes the reduction of blood pressure, prevents cardiovascular disease and has anticancer activity; thus, hydroxytyrosol is a natural antioxidant considered worthy of research and vigorous development (17,18). However, the neuroprotective effects of DOPET on SAH-induced EBI have not been investigated.…”

Pharmacokinetic profile and metabolite identification of bornyl caffeate and caffeic acid in rats by high performance liquid chromatography coupled with mass spectrometry

“…A survey of literature has showed that caffeic acid esters can be easily hydrolyzed to CA in vivo. 16,17 As a kind of caffeic acid ester, bornyl caffeate is composed of CA and borneol. We simultaneously examined the pharmacokinetics of bornyl caffeate and CA aer administration of a single dose of bornyl caffeate.…”

“…In terms of pharmacokinetics and stability, a survey of literature has showed that there are a number of methods for the determination of caffeic acid esters. [13][14][15] Among these assays, high performance liquid chromatography-tandem mass spectrometry (HPLC-MS/MS) is the most powerful and canonical technique to determine several caffeic acid esters such as 3,4-dihydroxyphenethyl caffeate, 16 phenethyl caffeate 17 and their metabolites in plasma. In most cases, these studies have focused on the stability of the compounds, but much less attention was paid to their pharmacokinetics.…”