In-vitro and in-vivo antimalarial activity of caffeic acid and some of its derivatives

Alson, Sylvain G; Jansen, Olivia; Cieckiewicz, Ewa; Rakotoarimanana, Hajatiana; Rafatro, Herintsoa; Degotte, Gilles; Francotte, Pierre; Frédérich, Michel

doi:10.1111/jphp.12982

Cited by 46 publications

(48 citation statements)

References 22 publications

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“…Hence, LA may be expected to exert toxicity to cultured P. falciparum via extracellular production of linoleate peroxides/epoxides (Guillaume, Calzada, Lagarde, Schrevel, & Deregnaucourt, ). Additionally, antiplasmodium potential of phenolics and flavonoids in GSO would have to be addressed via malaria parasite metabolism and development (Alson et al, ; Cai, Zhang, Ji, & Xing, ; Kusch et al, ; Palaniswamy, Pradeep, Sathya, & Angayarkanni, ).…”

Section: Discussionmentioning

confidence: 99%

Linoleic acid‐rich guava seed oil: Safety and bioactivity

Prommaban

Utama‐ang

Chaikitwattana

et al. 2019

Phytotherapy Research

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Guava (Psidium guajava) is a widely consumed fruit and has been commercialized in markets. The seeds are by-products of the processing procedures performed by the commercial guava juice industry. They are considered a nutritional resource that has been poorly utilized as they contain essential fatty acids such as linoleic acid (LA) and phenolics in abundance. In the study, guava seed oil (GSO) was used, which was obtained by hexane extraction of guava seeds to determine composition and test toxicity, cell migration, cancer cell viability, and plasmodium growth. GSO was found to be relatively nontoxic to normal hepatocytes and peripheral blood mononuclear cells, with mice for 14 days showing median lethal dose (LD 50 ) > 10 mg/kg and rats for up to 90 days. Surprisingly, the oil inhibited the proliferation of the human erythroleukemic cells in a dose-dependent manner with the half maximal inhibitory concentration values of 155 and 137 μg/ml at 24 and 48 hr, respectively. Importantly, GSO at 500 μg/ml was found to increase the degree of migration of keratinocytes (HaCaT). These observations suggest that edible P. guajava seed oil, which is abundant with linoleic acid and antioxidants, can promote skin wound healing and inhibit the proliferation of leukemic cells.

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Section: Discussionmentioning

confidence: 99%

Linoleic acid‐rich guava seed oil: Safety and bioactivity

Prommaban

Utama‐ang

Chaikitwattana

et al. 2019

Phytotherapy Research

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“…A number of reports on the biological activities of MC have focused on its potent anti-cancer properties [ 28 , 29 , 30 , 31 , 32 ]. Additionally, anti-microbial, anti-inflammatory, anti-platelet, anti-diabetic, hepatoprotective, or anti-senescence properties of MC have also been shown [ 33 , 34 , 35 , 36 , 37 , 38 ]. However, the neuroprotective properties of MC are less investigated.…”

Section: Introductionmentioning

confidence: 99%

Neuroprotective Effects of Methyl Caffeate against Hydrogen Peroxide-Induced Cell Damage: Involvement of Caspase 3 and Cathepsin D Inhibition

et al. 2020

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Finding effective neuroprotective strategies to combat various neurodegenerative disorders still remain a clinically unmet need. Methyl caffeate (MC), a naturally occurring ester of caffeic acid, possesses antioxidant and anti-inflammatory activities; however, its role in neuroprotection is less investigated. In order to better characterize neuroprotective properties of MC, we tested its effectiveness in various models of neuronal cell injury in human neuroblastoma SH-SY5Y cells and in mouse primary neuronal cell cultures. MC at micromolar concentrations attenuated neuronal cell damage induced by hydrogen peroxide (H2O2) in undifferentiated and neuronal differentiated SH-SY5Y cells as well as in primary cortical neurons. This effect was associated with inhibition of both caspase-3 and cathepsin D but without involvement of the PI3-K/Akt pathway. MC was neuroprotective when given before and during but not after the induction of cell damage by H2O2. Moreover, MC was protective against 6-OHDA-evoked neurotoxicity in neuronal differentiated SH-SY5Y cells via inhibition of necrotic and apoptotic processes. On the other hand, MC was ineffective in models of excitotoxicity (induced by glutamate or oxygen–glucose deprivation) and even moderately augmented cytotoxic effects of the classical apoptotic inducer, staurosporine. Finally, in undifferentiated neuroblastoma cells MC at higher concentrations (above 50 microM) induced cell death and when combined with the chemotherapeutic agent, doxorubicin, it increased the cell damaging effects of the latter compound. Thus, neuroprotective properties of MC appear to be limited to certain models of neurotoxicity and depend on its concentrations and time of administration.

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“…The C 6 -C 3 phenylpropanoid pathway is responsible for biosynthesizing various plant phenols that have biological activities like antioxidant, anti-microbial, anti-inflammatory, anti-cancer, anti-allergenic, antihypertensive, anti-thrombogenic and anti-platelet. 31 The antimalarial activity of phenols had been reported by Laphookhieo et al, 32 Morimoto et al 33 and Alson et al 34 .…”

Section: Phytopharmacology Of Acacia Pennata and Evidences For Their mentioning

confidence: 79%

Ethnopharmacology and phytochemistry-based review on the antimalarial potential of Acacia pennata (L.) Willd.

Zothantluanga¹

2020

Sci Vis

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A protozoan infection called malaria is caused by Plasmodium parasites. In 2018, it infected more than 228 million people and caused 405,000 fatalities. Worryingly, the present antimalarial drugs had developed drug resistance. Furthermore, they are associated with adverse effects and price issues. Amidst the gloomy scenario, drug discovery based on natural products had renewed the hope to overcome the burdens associated with the present antimalarial drugs. Auspiciously, medicinal plants had contributed significantly to the modern pharmacotherapy of malaria. Interestingly, Acacia pennata (L.) Willd. was also documented as a traditional antimalarial agent. However, there is still no scientific evidence regarding its antimalarial activity. Therefore, this article was aimed to study the phytochemical profile of A. pennata and explore their potential activity against malarial parasites. A. pennata contains different classes of bioactive compounds such as alkaloids, flavonoids, phenols, glycosides, terpenoids, phytosterols, and saponins whose antimalarial activities had been reported. Accordingly, the future scopes and challenges regarding the possible antimalarial activity for A. pennata are also discussed. To maximize the chances for finding a new antimalarial chemical entity from A. pennata, a schematic flow chart on the ethnopharmacology based drug discovery approach is also provided. Thus, this literary work may be used by researchers as a referential guide in the search for new antimalarial phytochemicals.

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In-vitro and in-vivo antimalarial activity of caffeic acid and some of its derivatives

Abstract: Our study provides evidence for an antimalarial potential of caffeic acid derivatives which are common in several medicinal plants traditionally used against malaria. It also demonstrates the possibility to use such derivatives in the treatment of malaria.

Cited by 46 publications

References 22 publications

Linoleic acid‐rich guava seed oil: Safety and bioactivity

Linoleic acid‐rich guava seed oil: Safety and bioactivity

Neuroprotective Effects of Methyl Caffeate against Hydrogen Peroxide-Induced Cell Damage: Involvement of Caspase 3 and Cathepsin D Inhibition

Ethnopharmacology and phytochemistry-based review on the antimalarial potential of Acacia pennata (L.) Willd.

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