Antithyroid Drugs in Iodine 131 Therapy of Hyperthyroidism

Einhorn, J.; Saterborg, N.- E.

doi:10.1177/028418516205800301

Cited by 2 publications

(3 citation statements)

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“…04). These data are in keeping with previous studies that have shown that the radioprotectant properties of PTU are most pronounced when PTU is used as pretreatment for RAI therapy and discontinued for less than 7-14 days before RAI dosing (Crooks et al, 1960;Einhorn & Saterborg, 1962;Reynolds & Kotchen, 1979;Tuttle et al, 1995). The RAI failure rate of 29% following PTU use within 4-7 days of RAI administration verifies the results of our previous report in which a 34% RAI failure rate was seen in a similar group of patients from another institution (Tuttle et al, 1995).…”

Section: Discussionsupporting

confidence: 91%

“…Pretreatment with antithyroid drugs (ATD) for several weeks before RAI therapy in order to deplete the thyroid gland of preformed stores of thyroid hormone is recommended for selected patients by many authors (Connell et al, 1987;Becker & Hurley, 1988;Cooper, 1994). This practice is now widely accepted but may be associated with a higher treatment failure rate than with RAI alone (Einhorn & Saterborg, 1962;Reynolds & Kotchen, 1979;Tuttle et al, 1995). Some studies have attributed the higher treatment failure rate of combined therapy to either patient selection bias or to inadequate time off ATDs before and after RAI (Steinbach et al, 1979;Bliddal et al, 1982;Connell et al, 1987;Velkeniers et al, 1988).…”

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confidence: 99%

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The effect of propylthiouracil on subsequent radioactive iodine therapy in Graves' disease

Hancock¹,

Rm²,

LeMar³

et al. 1997

Clinical Endocrinology

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Propylthiouracil discontinued 4-7 days before radioiodine dosing is associated with a significant increase in the failure rate of a single dose of radioiodine. Discontinuation of the propylthiouracil for at least a week before radioiodine administration is associated with a higher, although not statistically significant, radioiodine failure rate. In patients that require treatment with propylthiouracil before radioiodine therapy, a higher total serum thyroxine level at diagnosis is associated with an increased rate of radioiodine failure. Consideration should be given to increasing empirically the dose of radioiodine administered to Graves' disease patients that have received propylthiouracil within a week of radioiodine administration in an effort to decrease the radioiodine failure rate to an acceptable level.

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Section: Discussionsupporting

confidence: 91%

mentioning

confidence: 99%

The effect of propylthiouracil on subsequent radioactive iodine therapy in Graves' disease

Hancock¹,

Rm²,

LeMar³

et al. 1997

Clinical Endocrinology

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“…Raheem S and Nanayakkara D compared to methimazole or carbimazole. This is mainly due to the presence of sulfhydryl group in propylthiouracil, which is absent in carbimazole [20].…”

Section: Discussionmentioning

confidence: 99%