Antiseptic therapy with a polylacticacid-acetic acid matrix in burns

Ryssel, H.; Gazyakan, Emre; Germann, Günter; Hellmich, Susanne; Riedel, K.; Reichenberger, M; Radu, Christian Andreas

doi:10.1111/j.1524-475x.2010.00610.x

Cited by 9 publications

(8 citation statements)

References 32 publications

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“…For this reason, topical antibiotics [1] or antiseptic treatment may be required. Even antiseptic therapy, with a polylacticacid-acetic acid matrix, has an equivalent e ectiveness to silver sulfadiazine in the treatment of second and third degree burns [28]. In this study, in group 2, montelukast administration caused signi cant reduction in the density of neutrophil leukocytes on the 3 rd day -and to a similar extent as that seen with the application of pomade (group 3).…”

Section: Discussionsupporting

confidence: 54%

Effects of montelukast on burn wound healing in a rat model

Turtay

Fırat²,

Şamdancı³

et al. 2010

CIM

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Purpose: Montelukast, a selective cysteinyl leukotriene D4-receptor antagonist, is used in the treatment of asthma. In a rat model, our aim was to investigate the effects of montelukast, alone or in combination with topical antibiotics, on local burn wound healing. Methods: Rats were randomly allocated to four groups after local burn development: Group 1; rats were left to secondary healing without treatment, Group 2; a dose of 10 mg/kg montelukast was given by gastric gavage once a day for 10 days, Group 3; rats were treated with topical pomade (bacitracin neomycin sulphate), and Group 4; rats were treat with a combination of topical antibiotic and montelukast (10 mg/kg were given by gastric gavage once a day for 10 days). Skin biopsies were taken on days 3, 10, 14, and 20 relative to burn induction. Results: Reepithelialization in the pomade and montelukast+pomade groups on the 10th day was significantly greater, in comparison with control and montelukast groups (p < 0.05). For the montelukast group, edema (on the 14th day) and angiogenesis, fibroblast proliferation, edema and macrophage infiltration (on the 20th day) were statistically improved in comparison with the control group (p < 0.05). For the montelukast+pomade group, angiogenesis, fibroblast proliferation and macrophage infiltration (on the 10th day), and angiogenesis, fibroblast proliferation, edema and macrophage infiltration (on the 14th and 20th days) were statistically improved in comparison with the control group (p < 0.05). Conclusion: In conclusion, montelukast was effective on burn wound healing. Moreover, the effect was amplified when combined with topical antibiotics applied in the early stage of burn wound healing.

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Section: Discussionsupporting

confidence: 54%

Effects of montelukast on burn wound healing in a rat model

Turtay

Fırat²,

Şamdancı³

et al. 2010

CIM

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“…We believe this is unlikely to be the explanation, as Pseudomonas thrives in the airways of cystic fibrosis patients, which are relatively acidic [24]. Moreover, topical treatment of burn-wounded patients with a polylactic acid-acetic acid dressing did not decrease the resident bacterial bioburden, and Pseudomonas frequently remained present [25]. It also is possible that factors elaborated by Lactobacillus interfere with pseudomonal physiology directly, and there is some evidence that Lactobacillus can interfere specifically with Pseudomonas' capacity to form biofilm and to produce its quorum-sensing molecules [26].…”

Section: Discussionmentioning

confidence: 91%

Local Probiotic Therapy with Lactobacillus plantarum Mitigates Scar Formation in Rabbits after Burn Injury and Infection

Satish

Gallo

Johnson

et al. 2017

Surgical Infections

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Background: Infection is the most common complication in burn-injured patients and is believed to contribute to the hypertrophic scarring frequently observed in such injury. Pseudomonas aeruginosa is a common pathogen in burn wound infection. We examined the effect of local probiotic therapy with Lactobacillus plantarum on the severity of the scarring following burn wounding and infection with P. aeruginosa in a rabbit model. Methods: Full-thickness burn wounds were inoculated with control vehicle or L. plantarum; wounds were then challenged with bioluminescent P. aeruginosa. The time course of the ensuing infection was monitored by quantification of the emitted light. After allowing wounds to contract to near completion, they were harvested and analyzed for markers of scar formation. Results: Application of L. plantarum curtailed both the severity and the length of the pseudomonal infection. Probiotic therapy significantly reduced both Type I collagen mRNA concentrations and total collagen protein accumulation in infected wounds, consistent with reduced scarring. Surprisingly, the probiotic showed a nearly equivalent effect in uninfected wounds. Masson's trichrome staining confirmed these findings histologically. Conclusions: Lactobacillus plantarum shows exciting potential as a therapeutic agent to both counteract burn wound infection and to alleviate scarring even in the absence of infection.

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“…Acetic acid, on the other hand, creates weakly acidic or neutral states in wounds that boost oxygen saturation, and healing is promoted by the degradation of surface biofilms [ 6 , 7 , 8 , 9 ]. Because acetic acid soaks require at least two dressing changes daily, negative-pressure dressings seemed an ideal pairing, facilitating acid instillation by design.…”

Section: Introductionmentioning

confidence: 99%

Negative Pressure Wound Therapy of Chronically Infected Wounds Using 1% Acetic Acid Irrigation

Jeong

Lee

et al. 2015

Arch Plast Surg

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BackgroundNegative-pressure wound therapy (NPWT) induces angiogenesis and collagen synthesis to promote tissue healing. Although acetic acid soaks normalize alkali wound conditions to raise tissue oxygen saturation and deconstruct the biofilms of chronic wounds, frequent dressing changes are required.MethodsCombined use of NPWT and acetic acid irrigation was assessed in the treatment of chronic wounds, instilling acetic acid solution (1%) beneath polyurethane membranes twice daily for three weeks under continuous pressure (125 mm Hg). Clinical photographs, pH levels, cultures, and debrided fragments of wounds were obtained pre- and posttreatment. Tissue immunostaining (CD31, Ki-67, and CD45) and reverse transcription-polymerase chain reaction (vascular endothelial growth factor [VEGF], vascular endothelial growth factor receptor [VEGFR]; procollagen; hypoxia-inducible factor 1 alpha [HIF-1-alpha]; matrix metalloproteinase [MMP]-1,-3,-9; and tissue inhibitor of metalloproteinase [TIMP]) were also performed.ResultsWound sizes tended to diminish with the combined therapy, accompanied by drops in wound pH (weakly acidic or neutral) and less evidence of infection. CD31 and Ki-67 immunostaining increased (P<0.05) post-treatment, as did the levels of VEGFR, procollagen, and MMP-1 (P<0.05), whereas the VEGF, HIF-1-alpha, and MMP-9/TIMP levels declined (P<0.05).ConclusionsBy combining acetic acid irrigation with negative-pressure dressings, both the pH and the size of chronic wounds can be reduced and infections be controlled. This approach may enhance angiogenesis and collagen synthesis in wounds, restoring the extracellular matrix.

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Antiseptic therapy with a polylacticacid-acetic acid matrix in burns

Cited by 9 publications

References 32 publications

Effects of montelukast on burn wound healing in a rat model

Effects of montelukast on burn wound healing in a rat model

Local Probiotic Therapy with Lactobacillus plantarum Mitigates Scar Formation in Rabbits after Burn Injury and Infection

Negative Pressure Wound Therapy of Chronically Infected Wounds Using 1% Acetic Acid Irrigation

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