Effects of montelukast on burn wound healing in a rat model

Abstract

Purpose: Montelukast, a selective cysteinyl leukotriene D4-receptor antagonist, is used in the treatment of asthma. In a rat model, our aim was to investigate the effects of montelukast, alone or in combination with topical antibiotics, on local burn wound healing. Methods: Rats were randomly allocated to four groups after local burn development: Group 1; rats were left to secondary healing without treatment, Group 2; a dose of 10 mg/kg montelukast was given by gastric gavage once a day for 10 days, Group 3; rats were treated with topical pomade (bacitracin neomycin sulphate), and Group 4; rats were treat with a combination of topical antibiotic and montelukast (10 mg/kg were given by gastric gavage once a day for 10 days). Skin biopsies were taken on days 3, 10, 14, and 20 relative to burn induction. Results: Reepithelialization in the pomade and montelukast+pomade groups on the 10th day was significantly greater, in comparison with control and montelukast groups (p < 0.05). For the montelukast group, edema (on the 14th day) and angiogenesis, fibroblast proliferation, edema and macrophage infiltration (on the 20th day) were statistically improved in comparison with the control group (p < 0.05). For the montelukast+pomade group, angiogenesis, fibroblast proliferation and macrophage infiltration (on the 10th day), and angiogenesis, fibroblast proliferation, edema and macrophage infiltration (on the 14th and 20th days) were statistically improved in comparison with the control group (p < 0.05). Conclusion: In conclusion, montelukast was effective on burn wound healing. Moreover, the effect was amplified when combined with topical antibiotics applied in the early stage of burn wound healing.

Beneficial Effects of Montelukast Against Methotrexate-Induced Liver Toxicity: A Biochemical and Histological Study

“…It is reported that montelukast can reduce eosinophilic inflammation in the airways [35–37]. Besides CysLT 1 receptor antagonists or biosynthesis inhibitors ameliorate at ethanol-induced gastric mucosal damage [38] and wound healing [39, 40]. According to our results, montelukast treatment after Mtx injection reduced the MDA and MPO levels.…”

Beneficial Effects of Montelukast against Cisplatin-Induced Acute Renal Damage in Rats

“…[34][35][36] Besides, CysLT1 receptor antagonists or biosynthesis inhibitors ameliorate ethanol-induced gastric mucosal damage, 37,38 experimental colitis, 39 and wound healing. 22,40,41 Recently, Sener et al 16 have reported that montelukast has protective effects on chronic renal failure-induced multiple organ injury. They attributed this to montelukast's ability to inhibit neutrophil infiltration and apoptosis.…”

Otostegia persica extraction on healing process of burn wounds

“…Because of its oily and moisturizing features, topical antibiotics are required to promoting burn wound healing and re-epithelialisation 11 . Topical antimicrobial agents containing silver sulfadiazine have been used clinically to eliminate infections common in local burn wounds 12 . Therefore we compared treatment with OP pomade with no treatment and topical treatment alone.…”