Beneficial Effects of Montelukast against Cisplatin-Induced Acute Renal Damage in Rats

Abstract

Objective: In this study, the therapeutic and protective effects of montelukast against cisplatin (CP)-induced acute renal damage were investigated. Materials and Methods: Thirty-five female rats were divided into five groups as follows: (1) control, (2) montelukast (10 mg/kg daily for 10 days per-oral (p.o.), (3) CP (single dose 7 mg/kg intraperitoneally (i.p.)), (4) CP + montelukast (10 mg/kg daily for 10 days p.o., after 3 days of the injection of CP), (5) montelukast (10 mg/kg daily for 10 days p.o.) + CP (single dose 7 mg/kg i.p., after the last dose of montelukast). At the end of the experiment, malondialdehyde (MDA), a lipid peroxidation product, myeloperoxidase (MPO), and reduced glutathione (GSH) levels were determined in the renal tissue. Also, blood urea nitrogen (BUN) and creatinine (Cr) levels were assayed from the trunk blood samples. Results: CP treatment caused a significant elevation of MDA, MPO, BUN, and Cr levels when compared with the control group. Also, GSH levels were found to be reduced due to the CP treatment. Montelukast administration after CP injection ameliorated all of these parameters. Our histopathological findings (marked swelling of epithelial cells, tubular dilatation, tubular desquamation, and loss of brush border in the kidney) were consistent with the biochemical results. Conclusion: Montelukast treatment after CP injection exerted therapeutic effects against CP-induced acute kidney damage.

Renoprotective effects of montelukast in an experimental model of cisplatin nephrotoxicity in rats

“…The currently reported ML renoprotective efficacy against CIS is supported by a another study by Beytur et al . Since both LTR blocking and 5‐lipoxygenase inhibition confer renoprotection in CIS injury, hence LT plays a crucial role in such an ailment.…”

“…In renal dysfunction and urinary bladder sensitivity, ML protective potential is linked to the inhibition of release of inflammatory and oxidative stress mediators . ML protects against methotrexate and cisplatin (CIS) nephrotoxic effects. The latter authors showed that ML renoprotection is a function of the reduced oxidative stress and neutrophil infiltration.…”

“…reported a protective effect of 5‐lipoxygenase inhibition in a CIS‐induced renotoxicity model in rats. Hence, it is feasible that lipoxygenase metabolites play a prominent role in CIS kidney injury . Since ML protective mechanisms against CIS renal damage has not yet been fully elucidated, accordingly, this investigation was undertaken to divulge the effect of ML on CIS‐induced inflammation and apoptosis in the rat kidney.…”

Beneficial Effects of Short-Term Calorie Restriction against Cisplatin-Induced Acute Renal Injury in Aged Rats

“…There are experimental data suggesting that nephrotoxic drugs may also change the levels of BUN and SCr [22,23,24], which are commonly used to monitor the development and extent of renal tubular damage due to DDP [25]. Therefore, in this study we examined the levels of BUN and SCr after the application of DDP.…”

The valuable effects of potent antioxidant curcumin in cisplatin induced liver and kidney injury

“…It is known that CIS causes nephrotoxicity and nephrotoxicity is a strong factor to restrict usage of CIS 18 . In the present study; the deterioration of kidney functions was shown by increased serum BUN level, histopathological images of kidney as tubular epithelial necrosis, luminal necrotic debris and tubular dilatation and also histopathological kidney score in CIS administrated group.…”