Negative Pressure Wound Therapy of Chronically Infected Wounds Using 1% Acetic Acid Irrigation

Jeong, Hii Sun; Lee, Byeong Ho; Lee, Hye Kyung; Kim, Hyoung Suk; Moon, Min Seon; Suh, In Suck

doi:10.5999/aps.2015.42.1.59

Cited by 32 publications

(25 citation statements)

References 26 publications

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“…After 2-12 days, P. aeruginosa was eliminated [236]. Using NPWTi with 1% AA ( n = 3; instillation of 30 mL twice daily for 3 weeks, no control), the number of pathogens (MRSA, Gram-negative) was significantly reduced ( n = 2) or eliminated; this was associated with improved healing and a shift from highly basic pH to a weak basic or neutral pH [240] (Table 12). …”

Section: Future Perspectivesmentioning

confidence: 99%

Consensus on Wound Antisepsis: Update 2018

Krämer

Dissemond²,

Kim³

et al. 2017

Skin Pharmacol Physiol

243

215

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Wound antisepsis has undergone a renaissance due to the introduction of highly effective wound-compatible antimicrobial agents and the spread of multidrug-resistant organisms (MDROs). However, a strict indication must be set for the application of these agents. An infected or critically colonized wound must be treated antiseptically. In addition, systemic antibiotic therapy is required in case the infection spreads. If applied preventively, the Wounds-at-Risk Score allows an assessment of the risk for infection and thus appropriateness of the indication. The content of this updated consensus recommendation still largely consists of discussing properties of octenidine dihydrochloride (OCT), polihexanide, and iodophores. The evaluations of hypochlorite, taurolidine, and silver ions have been updated. For critically colonized and infected chronic wounds as well as for burns, polihexanide is classified as the active agent of choice. The combination 0.1% OCT/phenoxyethanol (PE) solution is suitable for acute, contaminated, and traumatic wounds, including MRSA-colonized wounds due to its deep action. For chronic wounds, preparations with 0.05% OCT are preferable. For bite, stab/puncture, and gunshot wounds, polyvinylpyrrolidone (PVP)-iodine is the first choice, while polihexanide and hypochlorite are superior to PVP-iodine for the treatment of contaminated acute and chronic wounds. For the decolonization of wounds colonized or infected with MDROs, the combination of OCT/PE is preferred. For peritoneal rinsing or rinsing of other cavities with a lack of drainage potential as well as the risk of central nervous system exposure, hypochlorite is the superior active agent. Silver-sulfadiazine is classified as dispensable, while dyes, organic mercury compounds, and hydrogen peroxide alone are classified as obsolete. As promising prospects, acetic acid, the combination of negative pressure wound therapy with the instillation of antiseptics (NPWTi), and cold atmospheric plasma are also subjects of this assessment.

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Section: Future Perspectivesmentioning

confidence: 99%

Consensus on Wound Antisepsis: Update 2018

Krämer

Dissemond²,

Kim³

et al. 2017

Skin Pharmacol Physiol

243

215

View full text Add to dashboard Cite

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“…Acetic acid has been investigated to prevent biofilms in the dental 41 , food 42 , and wound health 43 contexts. However, contact times are measured in hours, and there is less existing research relevant to cleaning storage containers.…”

Section: Discussionmentioning

confidence: 99%

Efficacy of locally-available cleaning methods in removing biofilms from taps and surfaces of household water storage containers

et al. 2020

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Biofilms are aggregates of microorganisms attached to surfaces that can (re)contaminate water by releasing microorganisms. We grew E. coli biofilms on household taps and on storage container coupons, and cleaned them with locally-available agents (bleach, boiled water, soapy water, vinegar) and methods (flowing, scrubbing, or soaking taps; soaking and wiping container coupons). After cleaning, we enumerated surface E. coli and imaged biofilms using epifluorescence microscopy. Biofilms were removed from taps when: soaking assembled for five minutes (bleach, boiled water); and, scrubbing and soaking unassembled for five minutes (bleach, boiled water, vinegar). Only soaking methods removed E. coli from container coupons. To remove biofilms, we recommend soaking assembled taps in boiled water for five minutes. No recommendation for cleaning containers emerged as soaking storage containers is impractical. Results are consistent with biofilm research, and highlight the need for technical research to develop realistic cleaning recommendations for water storage containers in households.

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“…As well as preventing infection and decreasing the bacterial load, NPWT has demonstrated a wide variety of merits in the treatment of complex wound defects. Previous studies have reported that NPWT is able to decrease wound size, maintain a moist atmosphere for wound healing, reduce edema and assist with the closure of areas not fully closed in the wound, also termed dead cavities (8,22). Notably, microscopically NPWT is able to promote granulation, vascularization, epithelialization and the synthesis of fibrin within the wound (23,24).…”

Section: Discussionmentioning

confidence: 99%

“…Previous studies regarding the use of NPWT primarily concern traumatic wounds with or without infection, and the most frequently used pressure is -80 to -125 mmHg (31). In cases with fragile wound edges, low perfusion, poor tolerability or skin grafts, a minor pressure (<125 mmHg) is often attempted (8). Furthermore, negative pressure protocols are typically used at one of two settings, namely, continuous or intermittent.…”

Section: Discussionmentioning

confidence: 99%

“…Negative pressure wound therapy (NPWT), also known as vacuum-assisted closure, is a revolutionary technique for the management of complex wounds. Previous studies have focused on the merits of NPWT compared with traditional methods in the treatment of complex wound defects (8). Despite a lack of high-level evidence, studies have indicated that NPWT may facilitate wound healing, prepare the wound bed for skin grafts or flaps, decrease the risk of infection and reduce the labor of clinicians (9)(10)(11).…”

Section: Introductionmentioning

confidence: 99%

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Use of negative pressure wound therapy as an adjunct to the treatment of extremity soft-tissue sarcoma with ulceration or impending ulceration

Chen

et al. 2016

Oncology Letters

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Abstract. Major wound complications of the extremities, following wide tumor resection and reconstruction for soft-tissue sarcomas (STSs), remain a challenge for limb-sparing surgery. Furthermore, STSs with ulceration or impending ulceration predispose patients to an increased risk of post-operative infection. The present study was conducted to assess the efficacy of negative pressure wound therapy (NPWT) in preventing wound complications associated with surgical treatment of STSs with ulceration or impending ulceration, in patients treated between February 2012 and January 2013. A total of 5 patients, with a mean age of 48 years (range, 24-68 years), were enrolled in the present study. The diagnoses consisted of undifferentiated pleomorphic sarcoma (n=2), leiomyosarcoma (n=1), synovial sarcoma (n=1) and epithelioid sarcoma (n=1). According to American Joint Committee on Cancer criteria, 3 cases were stage III tumors, and the remaining 2 cases were of stages ⅡA and ⅡB, respectively. A total of 3 patients exhibited ulceration at diagnosis, and the remaining patients demonstrated impending ulceration. The mean wound area following wide resection of the tumor was 73 cm 2 (range, 45-110 cm 2 ). A continuous suction mode, with pressures measuring -200 to -300 mmHg, was used for 7-10 days on the soft-tissue defects as preparation for wound closure. Soft-tissue reconstruction included muscle flaps (n=2) and skin grafts (n=5). No major wound complications occurred. Post-operative functional and cosmetic outcomes were acceptable. A single patient demonstrated local recurrence 12 months after surgery and re-excision of the tumor was performed. All patients remained alive at the conclusion of follow-up, with a mean follow-up time of 26 months (range, 12-36 months). The present study demonstrated that NPWT is effective and safe when used as an adjunct to wound closure following resection of extremity STS with ulceration/impending ulceration.

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Negative Pressure Wound Therapy of Chronically Infected Wounds Using 1% Acetic Acid Irrigation

Cited by 32 publications

References 26 publications

Consensus on Wound Antisepsis: Update 2018

Consensus on Wound Antisepsis: Update 2018

Efficacy of locally-available cleaning methods in removing biofilms from taps and surfaces of household water storage containers

Use of negative pressure wound therapy as an adjunct to the treatment of extremity soft-tissue sarcoma with ulceration or impending ulceration

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