Antischistosomal Activity of the Terpene Nerolidol

Silva, Marcos P.N.; Oliveira, George Laylson da Silva; Carvalho, Rusbene Bruno Fonseca de; Sousa, Damião Pergentino de; Freitas, Rivelilson Mendes de; Pintó, Pedro; Moraes, Josué de

doi:10.3390/molecules19033793

Cited by 55 publications

(40 citation statements)

References 43 publications

(49 reference statements)

Supporting

Mentioning

Contrasting

Unclassified

Order By: Relevance

“…Generally, if a drug induces tegumental alterations, the onset and precise pattern of these alterations depend on the particular drug and the treatment regimen used (44) . The characteristic features of tegumental damage observed in this study, including destruction of the tegument and erosion and loss of spines, were consistent with those previously described in the literature following in vitro exposure to different antischistosomal agents such as hypericin (45) , allicin (46) , nerolidol (47) , phthalyl thiazole (LpQM-45) (48) , β-lapachone (49) , and DNK (32) . Hence, reductions in worms may be attributed to the tegumental damage observed.…”

Section: Discussionsupporting

confidence: 76%

In vitro antischistosomal activity of venom from the Egyptian snake Cerastes cerastes

Hassan

Abdel-Rahman

Ibrahim

et al. 2016

Rev. Soc. Bras. Med. Trop.

View full text Add to dashboard Cite

Introduction:We studied the potential in vitro antischistosomal activity of Cerastes cerastes venom on adult Schistosoma mansoni worms. Methods: Live specimens of the horned viper snake, C. cerastes were collected from the Aswan Governorate (Egypt). Venom was collected from snakes by manual milking. Worms of S. mansoni were obtained from infected hamsters by perfusion and isolated from blood using phosphate buffer. Mortality rates of worms were monitored after 3 days of exposure to snake venom at LC 50 and various sublethal concentrations (10, 5, 2.5µg/ml). Scanning electron microscopy was used to investigate tegumental changes in treated worms after exposure to LC 50 doses of venom. Results: The LC 50 of C. cerastes venom was 21.5µg/ml. The effect of C. cerastes venom on Schistosoma worms varied according to their sex. The mortality rate of male and female worms after 48-h exposure was 83.3% and 50% , respectively. LC 50 of C. cerastes venom induced mild to severe tegumental damage in Schistosoma worms in the form of destruction of the oral sucker, shrinkage and erosion of the tegument, and loss of some tubercle spines. Conclusions: The present study demonstrated that C. cerastes venom exerts potential in vitro antischistosomal activity in a time and dose-dependent manner. These results may warrant further investigations to develop novel schistosomicidal agents from C. cerastes snake venom.

show abstract

Section: Discussionsupporting

confidence: 76%

In vitro antischistosomal activity of venom from the Egyptian snake Cerastes cerastes

Hassan

Abdel-Rahman

Ibrahim

et al. 2016

Rev. Soc. Bras. Med. Trop.

View full text Add to dashboard Cite

show abstract

“…The terpenes with antischistosomal activity are: rotundifolone [66], (+)-limonene epoxide [56], and carvacryl acetate, a derivative of carvacrol (monoterpenes) [39]; artemisinin and its derivatives [30,31], nerolidol [59], and budlein-A and its derivatives [38] (sesquiterpenes); phytol [60] (diterpene), betulin [37] and its triphenylphosphonium derivatives [69], balsaminol F, karavilagenin C [36] (triterpenes) (Figure 1). Importantly, among the group of terpenes, in vitro and in vivo antischistosomal properties have been described only for artemisinin and its derivatives, phytol and triphenylphosphonium derivatives, whereas it was reported in vitro schitosomicidal activity for other terpenes (Table 1).…”

Section: Terpenesmentioning

confidence: 99%

Natural Products with Antischistosomal Activity

Moraes¹

2015

Future Med. Chem.

View full text Add to dashboard Cite

In recent years, natural product groups have been gaining prominence as possible sources of new drugs for schistosomiasis. This review attempts to update the antischistosomal natural compounds, or natural product-derived compounds, from the mid-1980s. Some of the main metabolites obtained from plants (e.g., terpenes, alkaloids, phenolic compounds and peptides) with in vitro and/or in vivo antischistosomal properties are discussed. Less thoroughly, due to scarcity of data in the literature, molecules from animals (e.g., peptides) are also described. Special mention of the anthelmintic activity against different parasitic stages of schistosomes is made; the mechanism of action of most of the metabolites is discussed, and a number of bioassay procedures are listed.

show abstract

“…Different responses in antischistosomal drugs susceptibility between male and female S. mansoni worms have been described by Silva et al [24], were males are more sensible to the nerolidol terpene. On the other hand, Mitsui et al [29], show that S. mansoni females are more sensible to artesunate sesquiterpene.…”

Section: Discussionmentioning

confidence: 91%

“…Other authors observed similar tegumental alterations after evaluating different sesquiterpenes in vitro. e.g Dihydroartemisinin 4a,5-dihydrobudlein A, Nerolidol [22][23][24].…”

Section: Discussionmentioning

confidence: 99%