Natural Products with Antischistosomal Activity

Moraes, Josué de

doi:10.4155/fmc.15.23

Cited by 81 publications

(54 citation statements)

References 105 publications

(247 reference statements)

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“…Therefore, widespread emergence of drug resistance is probable and makes the development of new therapeutic approaches against schistosomiasis mandatory. In the past years, numerous natural products and synthetic drugs have been evaluated as potential schistosomicidal agents [18,19], but few studies have shown the effects of these drugs on the induction of apoptosis in this parasite. Curcumin (CUR), a secondary metabolite of turmeric derived from C .…”

Section: Discussionmentioning

confidence: 99%

“…Such new drugs could be potentially applied in the treatment of neglected tropical diseases (NTD), including schistosomiasis [18,19]. Curcumin (1,7-bis(4-hydroxy-3-methoxyphenyl)-1,6 heptadiene-3,5-dione) (CUR) is the major curcuminoid compound extracted from Curcuma longa L., a plant that possesses many pharmacological and biological activities [20], including antiparasitic action [21–25].…”

Section: Introductionmentioning

confidence: 99%

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Curcumin Generates Oxidative Stress and Induces Apoptosis in Adult Schistosoma mansoni Worms

et al. 2016

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Inducing apoptosis is an interesting therapeutic approach to develop drugs that act against helminthic parasites. Researchers have investigated how curcumin (CUR), a biologically active compound extracted from rhizomes of Curcuma longa, affects Schistosoma mansoni and several cancer cell lines. This study evaluates how CUR influences the induction of apoptosis and oxidative stress in couples of adult S. mansoni worms. CUR decreased the viability of adult worms and killed them. The tegument of the parasite suffered morphological changes, the mitochondria underwent alterations, and chromatin condensed. Different apoptotic parameters were determined in an attempt to understand how CUR affected adult S. mansoni worms. CUR induced DNA damage and fragmentation and increased the expression of SmCASP3/7 transcripts and the activity of Caspase 3 in female and male worms. However, CUR did not intensify the activity of Caspase 8 in female or male worms. Evaluation of the superoxide anion and different antioxidant enzymes helped to explore the mechanism of parasite death further. The level of superoxide anion and the activity of Superoxide Dismutase (SOD) increased, whereas the activity of Glutathione-S-Transferase (GST), Glutathione reductase (GR), and Glutathione peroxidase (GPX) decreased, which culminated in the oxidation of proteins in adult female and male worms incubated with CUR. In conclusion, CUR generated oxidative stress followed by apoptotic-like-events in both adult female and male S. mansoni worms, ultimately killing them.

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Section: Discussionmentioning

confidence: 99%

Section: Introductionmentioning

confidence: 99%

Curcumin Generates Oxidative Stress and Induces Apoptosis in Adult Schistosoma mansoni Worms

et al. 2016

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“…In recent years, an extensive attention to natural products as a treatment of neglected tropical diseases, including schistosomiasis, has been growing. The awareness has stimulated an exertion to improve a new medicine as a substitute method to this parasitosis control [9, 10, 38]. …”

Section: Discussionmentioning

confidence: 99%

“…The research on medicinal plants is encouraged by the WHO, considering that certain traditional knowledge on curative plants could add up to the development of new pharmaceutical products as well as to the combat against diseases that affects the populations of developing countries [9, 10]. …”

Section: Introductionmentioning

confidence: 99%

Comparative Evaluation of Anthelmintic Activity of Edible and Ornamental Pomegranate Ethanolic Extracts againstSchistosoma mansoni

Yones

Badary

Sayed

et al. 2016

BioMed Research International

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Due to the development of praziquantel (PZQ) schistosomes resistant strains, the discovery of new antischistosomal agents is of high priority in research. This work reported the in vitro and in vivo effects of the edible and ornamental pomegranate extracts against Schistosoma mansoni. Leaves and stem bark ethanolic extracts of both dried pomegranates were prepared at 100, 300, and 500 μg/mL for in vitro and 600 and 800 mg/kg for in vivo. Adult worms Schistosoma mansoni in RPMI-1640 medium for in vitro and S. mansoni infected mice for in vivo tests were obtained from Theodor Bilharz Research Institute, Cairo, Egypt. In vitro activity was manifested by significant coupled worms separation, reduction of motor activity, lethality, and ultrastructural tegumental alterations in adult worms. In vivo activity was manifested revealed by significant reduction of hepatic granulomas number and diameter, decreased number of bilharzial eggs in liver tissues, lowered liver inflammatory infiltration, decreased hepatic fibrosis, and inducible nitric oxide synthase (iNOS) expression. Ethanolic stem bark extract of edible pomegranate exhibited highest antischistosomal activities both in vitro and in vivo. Therefore, pomegranate showed a good potential to be used as a promising new candidate for the development of new schistosomicidal agents.

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“…As a result, many compounds with promising antischistosomal properties have been identified by academia (5). Among these, piplartine (piperlongumine) and curcumin have also been described as promising anticancer agents (6,7).…”

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confidence: 99%

Antischistosomal Activity of Oxindolimine-Metal Complexes

Moraes

Dário

Couto

et al. 2015

Antimicrob Agents Chemother

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In recent years, a class of oxindole-copper and -zinc complex derivatives have been reported as compounds with efficient proapoptotic activity toward different tumor cells (e.g., neuroblastomas, melanomas, monocytes). Here we assessed the efficacy of synthesized oxindole-copper(II), -zinc(II), and -vanadyl (VO 2؉ ) complexes against adult Schistosoma mansoni worms. The copper(II) complexes (50% inhibitory concentrations of 30 to 45 M) demonstrated greater antischistosomal properties than the analogous zinc and vanadyl complexes regarding lethality, reduction of motor activity, and oviposition.

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Natural Products with Antischistosomal Activity

Cited by 81 publications

References 105 publications

Curcumin Generates Oxidative Stress and Induces Apoptosis in Adult Schistosoma mansoni Worms

Curcumin Generates Oxidative Stress and Induces Apoptosis in Adult Schistosoma mansoni Worms

Comparative Evaluation of Anthelmintic Activity of Edible and Ornamental Pomegranate Ethanolic Extracts againstSchistosoma mansoni

Antischistosomal Activity of Oxindolimine-Metal Complexes

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