Antiretroviral therapy adherence and its determinant factors among people living with HIV/AIDS: a case study in Iran

Morowatisharifabad, Mohammad Ali; Movahed, Ehsan; Farokhzadian, Jamileh; Nikooie, Ruhollah; Hosseinzadeh, Mahdieh; Askarishahi, Mohsen; Bidaki, Reza

doi:10.1186/s13104-019-4204-5

Cited by 19 publications

(15 citation statements)

References 13 publications

(26 reference statements)

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“…Our research analyzed numerous lost to follow uprelated socio-demographic and clinical variables and found they were all substantially associated with improved antiretroviral therapy correlating with the study done in Iran. 19 Male patients were nearly twice as likely as their female counterparts to be lost to follow-up from antiretroviral therapy, study findings in Gonder, 20 Oromia, 4 Goba, 21 India, 18 Aksum 20 reported similarly while study results in Ethiopia 22 and Malawi contrasts the finding since these research findings suggest that males were more likely to conform to antiretroviral therapy. 17 This result shows that in antiretroviral therapy patients, gender is a sensitive problem that requires focus and attention.…”

Section: Discussionmentioning

confidence: 84%

Influence of Lost to Follow Up from Antiretroviral Therapy Among Retroviral Infected Patients at Tuberculosis Centers in Public Hospitals of Benishangul-Gumuz, Ethiopia

Degavi¹

2021

HIV

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Background: Broadening access to healthcare (ART) antiretroviral therapy has led to a 19% reduction in the death rate of people infected with the human immunodeficiency virus. This study would also describe the status and deciding factors of ART in (TB) tuberculosis centers in public hospitals of Benishangul-Gumuz, Ethiopia, for (LTFU) lost follow-up among (RVI) retroviral infected patients. Methods: Hospital-based, unrivalled analysis of the case management (3:1) design was conducted. A total of 752 study participants (563 controls and 189 cases) Picked by systematic random sampling methodology, and where reviewed their charts from TB Centers. Data were entered and cleaned using Epi data version 3.1.1 and then exported to SPSS version 22 for analysis. To analyze the statistical relationship between the outcome variable and independent variables, binary logistic regression was used. Relevance was declared at a p-value <0.05. Results: A total of 1122 (25.3%) were LTFU. Among index cases with male cases, there were higher odds of lost to follow up (AOR= 1.68, 95% CI; 1.085, 2.609), 15-24 old age group have no formal education, civil servant were also having high comparatively. In index cases with identified parents, the risk of LTFU up had lower HIV status (AOR=0.5; 95% CI; 0.24, 0.997). Rest all variables showed low odds to LTFU. Conclusion: A large number of patients enrolled in ARTwere missing from follow-up at TB centers, but unfortunately did not make the next appointment reported. The absence of prophylaxis was accepted as an independent determinant of LTFUfor ART.

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Section: Discussionmentioning

confidence: 84%

Influence of Lost to Follow Up from Antiretroviral Therapy Among Retroviral Infected Patients at Tuberculosis Centers in Public Hospitals of Benishangul-Gumuz, Ethiopia

Degavi¹

2021

HIV

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“…In the current study, the IM nonadherence of the patients was 33.53%, which was in accordance with previously reported 5–50% range of nonadherence rate in renal transplantation ( Leendertse et al, 2008 ; Germani et al, 2011 ). Forgetfulness was one of the major reasons for nonadherence to medications in other clinical settings such as HIV ( Morowatisharifabad et al, 2019 ). Better drug reminder also effectively reduced the rate of nonadherence.…”

Section: Discussionmentioning

confidence: 99%

Identification of Immunosuppressive Medication Nonadherence Factors Through a Combined Theory Model in Renal Transplant Recipients

et al. 2021

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Background: Immunosuppressive medication (IM) nonadherence is associated with poor transplant outcomes. Therefore, it is of great importance to identify predictive factors with IM nonadherence. We aimed to improve the predicted capacity of the theory of planned behavior (TPB) by adding health belief model’s (HBM) variables in renal transplant patients (RTPs).Methods: This cross-sectional study distributed questionnaires to patients who had undergone renal transplant and follow-up regularly in the transplant center of Third Xiangya Hospital in China. The self-developed questionnaire collected data in three aspects: general data questionnaire, TPB, HBM-specific questionnaire, and Basel Assessment of Adherence to Immunosuppressive Medications scale.Results: A total of 1,357 of 1,480 patients completed the survey, with a participation rate of 91.69% and IM nonadherence rate of 33.53%. The marital status, household income, preoperative drinking history, the time after transplantation, and religion showed independent predictive factors with IM nonadherence (p < 0.05). Strikingly, adding HBM variables to the TPB theory model significantly increased its prediction ability to IM nonadherence (52%). Also, HBM manifested the highest coefficient of effect (−0.620). Particularly, perceived barriers and perceived seriousness, the variables of the HBM model, played a vital influence on medication nonadherence (−0.284 and 0.256).Conclusion: Our study here reveals the first investigation of the combined effects of the TPB and HBM model on IM nonadherence in Chinese RTPs, which could significantly improve the predictive ability of any single model. Meanwhile, future interventions should be conducted to both increase perceived seriousness and reduce perceived barriers for taking IM, which will effectively decrease IM nonadherence rates and improve transplant outcomes.

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“…Another study reported forgetfulness and high drug dosage as common reasons for non-adherence. [ 13 ]…”

Section: Discussionmentioning

confidence: 99%

Assessment of adherence and factors contributing to non-adherence among patients on anti-retroviral therapy in a tertiary care hospital: A cross sectional study

Hadaye

Jambhale²,

Shastri³

2020

J Family Med Prim Care

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Background: For the successful treatment of human immunodeficiency virus (HIV), it is important that drugs should be taken regularly. Non-adherence not only increases chances of failure of treatment but also leads to the development of resistance to drugs and hence more focus has been given to adherence in the treatment protocol of HIV. Objectives: To determine the level of adherence, its determinants, and to ascertain reasons for non-adherence of antiretroviral therapy (ART) in patients with HIV/acquired immunodeficiency syndrome (AIDS). Methods: A cross-sectional study conducted at an adult ART clinic over a period of one year. The sample size was 320. A systematic random sampling technique was used. Semi-structured Adult AIDS Clinical Trials Group questionnaire was used. Beck Depression Inventory (BDI-II) for current depression and self-report of four days recall method and multi-method approach were used for adherence measurement. Results: The mean age of respondents was 37.26 ± 8.3 years. About 60.3% were males, 34.1% females, and 5.6% were transgenders (TGs). High adherence was found in 87.2% by self-report and 72.5% by multi-method approach. History of opportunistic infection and depression were found to be the best predictors of adherence. Reasons for short term non-adherence were found to be simply forgot to take medications, being away from home, busy with other things, and ran out of pills. Reasons for long-term non-adherence were financial difficulty, side-effects, and shift to alternate therapy. Conclusions: Significant non-adherence to ART necessitates addressing adherence issues in pre-ART counseling, the involvement of family and social support.

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Antiretroviral therapy adherence and its determinant factors among people living with HIV/AIDS: a case study in Iran

Cited by 19 publications

References 13 publications

Influence of Lost to Follow Up from Antiretroviral Therapy Among Retroviral Infected Patients at Tuberculosis Centers in Public Hospitals of Benishangul-Gumuz, Ethiopia

Influence of Lost to Follow Up from Antiretroviral Therapy Among Retroviral Infected Patients at Tuberculosis Centers in Public Hospitals of Benishangul-Gumuz, Ethiopia

Identification of Immunosuppressive Medication Nonadherence Factors Through a Combined Theory Model in Renal Transplant Recipients

Assessment of adherence and factors contributing to non-adherence among patients on anti-retroviral therapy in a tertiary care hospital: A cross sectional study

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