Antiproliferation effects of Glycine max Linn ethanolic extract on induced mammary gland carcinoma in albino rats

Triana, N. M.; Wilujeng, None Estiary; Putri, Meiriani; Yuda, D. M. P.; Hardiono, A. L.; Purnama, Muhammad Thohawi Elziyad; Fikri, Faisal

doi:10.1088/1755-1315/441/1/012103

Cited by 2 publications

(1 citation statement)

References 8 publications

Supporting

Mentioning

Contrasting

Order By: Relevance

“…Natural ingredients need to be extracted to get some or all of the active ingredients used to synthesize the right dosage, easily stored, and maintain for a long time. The extracted material can be in the form of fresh ingredients or powder 13 . The active ingredient of capsaicin is efficacious as a stimulant of gastric acid secretion and prevents infections in the digestive system.…”

Section: Resultsmentioning

confidence: 99%

Analysis of Capsicum annuum L. Methanolic Extract and Its Potential as a Hepatoprotector

Mustofa Helmi Effendi,

Mohammad Sukmanadi

2021

Indian Journal of Forensic Medicine & Toxicology

View full text Add to dashboard Cite

ThinLayerChromatography(TLC) method performed to purify capsaicin compound in C. annum L. and test the bioactive component of Capsicum Annum L on MAPK1 target proteins using the Immunohistochemistry (IHC) method to determine the reactions between receptor-ligand (antigen-antibody) complexes formed and become a reference in vivo tests. Natural ingredients need to be extracted to get some or all of the active ingredients used to synthesize the right dosage, easily stored, and maintain for a long time. The active ingredient of capsaicin is efficacious as a stimulant of gastric acid secretion and prevents infections in the digestive system.The immunohistochemical examination is intended to determine the expression of MAPK1 (ERK) on cells of mice hepatocytes (Mus musculus). MAPK 1 (ERK) expression score data were obtained using the modified Remmele method is the result of multiplying the percentage score of immunoreactive cells with the color intensity score on immunoreactive cells. The abnormal target protein signaling pathway contributes to cell proliferation, differentiation, survival, and uncontrolled cell apoptosis.Analysis of amino acid residues, Capsaicin to MAPK1haverelativelysimilarresiduessothatitcanbeconcludedthat the binding sites of the two compounds are close to similarities and affect receptors at relatively similar sites, namely oncogenicreceptors/ proteins. Concluded that the ethanol extract of Capsicum. annum L. had a greater in the powder form , TLC method showed the capsaicin standard was 1020 µg/ml, that capsaicin in chilies (Capsicum Annum L.) can synergistically inhibit cell through reactions in the anti-apoptotic MAPK 1 potentiates the antiproliferative action that can promote hepatoprotector, a finding that demands further clinicaltesting.

show abstract

Section: Resultsmentioning

confidence: 99%

Analysis of Capsicum annuum L. Methanolic Extract and Its Potential as a Hepatoprotector

Mustofa Helmi Effendi,

Mohammad Sukmanadi

2021

Indian Journal of Forensic Medicine & Toxicology

View full text Add to dashboard Cite

show abstract

Lime Peel Liquid (Citrus aurantifolia, Swingle) Inhibit Escherichia Coli In Vitro

et al. 2021

View full text Add to dashboard Cite

The purpose of this study was to determine in vitro inhibition test of lime peel liquid (Citrus aurantifolia, Swingle) against E. coli. The E. coli isolate was cultured on Muller Hinton Agar (MHA) media. Antibacterial test in this study using diffusion method. Negative control (K-) using CMC-Na 0.1%. Positive control (K+) using oxytetracycline antibiotics. The treatments were given lime peel liquid (Citrus aurantifolia, Swingle) with concentrations of 100%, 75%, 50% and 25%, respectively. The study design using Completely Randomized Design (CRD) method, with six treatments and four repetitions. Data were analyzed by Kruskal-Wallis test, Moreover, the Post Hoc Mann-Whitney method. The inhibition zone analysis results were showed that K + had significant differences compared to all treatments K-, 100%, 75%, 50%, and 25%. K- was found to be significantly different from treatments 100%, 75%, 50% and 25%. The results showed that the lime peel liquid has the potential as an antibacterial activity against the growth of E. coli in vitro. Concentration of 25% has shown the presence of inhibitory zones on Mueller Hinton media that have been inoculated with lime peel liquid.

show abstract

Antiproliferation effects of Glycine max Linn ethanolic extract on induced mammary gland carcinoma in albino rats

Cited by 2 publications

References 8 publications

Analysis of Capsicum annuum L. Methanolic Extract and Its Potential as a Hepatoprotector

Analysis of Capsicum annuum L. Methanolic Extract and Its Potential as a Hepatoprotector

Lime Peel Liquid (Citrus aurantifolia, Swingle) Inhibit Escherichia Coli In Vitro

Contact Info

Product

Resources

About