Antiplatelet Effects and Vasorelaxing Action of Some Constituents of Formosan Plants

Chung, Mei‐Ing; Gan, Kim-Hong; Lin, Chun‐Nan; Ko, Feng‐Nien; Teng, Che-Ming

doi:10.1021/np50096a018

Cited by 52 publications

(35 citation statements)

References 4 publications

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“…The present study demonstrates that CP-8-O-glc was the most potent of the four compounds examined, in terms of in- hibiting platelet aggregation, and suggests that it has therapeutic potential for the prevention of platelet hyperactivity-related cardiovascular diseases. In addition, in agreement with a previous study (22), emodin was found to have antiplatelet activity in the present study. Anthraquinone derivatives are considered to be the important constituent in this plant.…”

Section: Discussionsupporting

confidence: 94%

Chrysophanol-8-O-glucoside, an Anthraquinone Derivative in Rhubarb, Has Antiplatelet and Anticoagulant Activities

et al. 2012

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Abstract. Rhubarb is a widely used traditional medicine and has been reported to elicit a number of biological effects including anti-inflammatory and antiplatelet effects. In the present study, we investigated the effects of anthraquinone derivatives isolated from rhubarb on platelet activity. Of four anthraquinone derivatives isolated from rhubarb examined, chrysophanol-8-O-glucoside (CP-8-O-glc) was found to have the most potent inhibitory effect on collagen-and thrombin-induced platelet aggregation. CP-8-O-glc-treated mice showed significantly prolonged bleeding times. Furthermore, CP-8-O-glc was found to have a significant inhibitory effect on rat platelet aggregation ex vivo and on thromboxane A 2 formation in vitro. In coagulation tests, CP-8-O-glc did not alter prothrombin time, and it prolonged the activated partial thromboplastin time. However, CP-8-O-glc only inhibited platelet phosphatidylserine exposure, but not exert direct inhibition on intrinsic factors. This study demonstrates the antiplatelet and anticoagulant effects of CP-8-O-glc and suggests that this compound might be of therapeutic benefit for the prevention of plateletrelated cardiovascular diseases.

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Section: Discussionsupporting

confidence: 94%

Chrysophanol-8-O-glucoside, an Anthraquinone Derivative in Rhubarb, Has Antiplatelet and Anticoagulant Activities

et al. 2012

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“…Rutin induced 98% inhibition on ADP-induced platelet aggregation at 60 μg/ml which is in accordance with previously reported data in literature about quercetin related fl avonoids inhibitory action on washed rabbit platelets (Chung et al 1993).…”

Section: Discussionsupporting

confidence: 92%

Platelet Aggregation Inhibitors from Aerial Parts of Ruta Chalepensis Grown in Jordan

Shehadeh

Afifi

Abuhamdah

2007

Integr Med�Insights

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Abstract:From the aerial parts of Ruta chalepensis L., grown in Jordan, two furanocoumarins (bergapten and chalepensin), one fl avonoid glycoside (rutin) as well as several minor compounds have been isolated. The structural elucidation of these compounds was established based on spectral data (UV, IR, MS, 1 H-NMR and 13 C-NMR). In Jordan, R. chalepensis is recommended for the treatment of rheumatism, mental disorders and menstrual problems. Fresh and dried leaves are used as fl avoring agent in food and beverages. Antiplatelet activities of the crude methanolic and ethylacetate extracts in addition to the three isolated major compounds were measured by the aggrometric method according to Beretz and Casenave. Optical aggregometer connected to dual channel recorder was used for measuring aggregation. Both, ethylacetate and methanol extracts inhibited ADP-induced platelet aggregation (ADP-IA) of human blood. However, only ethylacetate extract was able to induce 50% inhibition of collagen-induced platelet aggregation (Co-IA) platelet rich plasma. Bergapten was more active against ADP-IA compared to chalepensin while the latter was more active against Co-IA compared to bergapten.

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“…Rutin (Scheme 1) is a kind of flavonoid glycoside known as Vitamin P and has capacity in antiplatelet, antiviral, antihypertensive, and strengthing the capillaries of blood vessels [10,11], which are the results of its high radical scavenging activity and antioxidant capacity [12][13][14]. These properties are potentially beneficial in preventing diseases and protecting the stability of the genome.…”

Section: Introductionmentioning

confidence: 99%

Combined antioxidant effects of rutin and Vitamin C in Triton X-100 micelles

Guo

Wei

Liu

2007

Journal of Pharmaceutical and Biomedical Analysis

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Antiplatelet Effects and Vasorelaxing Action of Some Constituents of Formosan Plants

Cited by 52 publications

References 4 publications

Chrysophanol-8-O-glucoside, an Anthraquinone Derivative in Rhubarb, Has Antiplatelet and Anticoagulant Activities

Chrysophanol-8-O-glucoside, an Anthraquinone Derivative in Rhubarb, Has Antiplatelet and Anticoagulant Activities

Platelet Aggregation Inhibitors from Aerial Parts of Ruta Chalepensis Grown in Jordan

Combined antioxidant effects of rutin and Vitamin C in Triton X-100 micelles

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