Antiplatelet aggregation activity of compounds isolated from Guttiferae species in human whole blood

Natural products as a source of Alzheimer's drug leads

“…151 Other xanthones from Gentiana campestris L. (Gentianaceae) leaf inhibit AChE; optimum inhibitory activity was associated with absence of a glucopyranosyl, and a methoxy group present in position C-3, since the most potent inhibitor, bellidifolin ( 84 ), was similar in potency to galantamine ( 15 ). 152 Macluraxanthone ( 85 ) (occurs in some Guttiferae) is a potent non-competitive AChE inhibitor, 137 but it also inhibits platelet aggregation, 153 therefore therapeutic development could be limited due to the potential for drug interactions with antiplatelet / anticoagulant drugs.…”

“…Terpenoids reported to have anti-aggregation activity are highly lipophilic and include retinol (150), retinal (151), and retinoic acid (152) (components of vitamin A), as well as b-carotene (153). Although vitamin A and 153 could inhibit the aggregation of fAb 40 and fAb 42 , and destabilize them in vitro, these compounds could not depolymerize amyloid fibrils into monomers or oligomers.…”

Antiplatelet and Anticoagulant Effects of Two New Phenylpropanoid Sucrose Esters and Other Secondary Metabolites from the Aerial Part of Canna edulis

“…Eleven known compounds were isolated and identified as 6’‐acetyl‐3,6,2’‐tri‐p‐coumaroyl sucrose ( 3 ), [13] 6′‐acetyl‐3,6,2′‐triferuloyl sucrose ( 4 ), [13] tiliroside ( 5 ), [15] afzelin ( 6 ), [16] quercitrin ( 7 ), [17] 2‐hydroxycinnamaldehyde ( 8 ), [18] cinnamic acid ( 9 ), [19] 3,4‐dimethoxycinnamic acid ( 10 ), [20] dehydrovomifoliol ( 11 ), [21] 4‐hydroxy‐3,5‐dimethoxybenzaldehyde ( 12 ), [22] and (S)‐(−)‐rosmarinic acid ( 13 ) [23] by comparison of NMR data with those reported in the literature (Figure 3). Among the previously reported compounds, 3 , 4 , 6–9 , 13 have been documented for their antiplatelet aggregation and anticoagulant activities [24–28] . Cinnamic acid ( 9 ) and its derivative, 2‐hydroxycinnamaldehyde ( 8 ), also had anticancer, [29,30] and anti‐inflammatory properties [31–33] .…”

“…Among the previously reported compounds, 3, 4, 6-9, 13 have been documented for their antiplatelet aggregation and anticoagulant activities. [24][25][26][27][28] Cinnamic acid (9) and its derivative, 2-hydroxycinnamaldehyde (8), also had anticancer, [29,30] and anti-inflammatory properties. [31][32][33] Additionally, 8 was found to contribute to the restoration of liver function in cases of acetaminophen-induced acute liver injury.…”

Bioactive compounds and functional foods as coadjuvant therapy for thrombosis

“…In context, acetylsalicylic acid inhibited 42 and 31% of platelet aggregation induced by ADP (10 μM) and collagen (2 μg mL −1 ), respectively, at a concentration of 25 μg mL −1 equivalent to 138 μM. 85 Thus, both phenanthrenes and zingerone exhibited a greater antiplatelet effect. Similarly, Zhou et al 41 and Riaz & Khan 33 reported that the extracts of pomegranate and Asiatic bittersweet had a greater in vitro effect than that exhibited by acetylsalicylic acid.…”