The SARS‐CoV‐2 outbreak has been one of the largest public health crises globally, while thrombotic complications have emerged as an important factor contributing to mortality. Therefore, compounds that regulate the processes involved in thrombosis could represent a dietary strategy to prevent thrombotic complications involved in COVID‐19. In August 2022, various databases were consulted using the keywords “flavonoids”, “antiplatelet”, “anticoagulant”, “fibrinolytic”, and “nitric oxide”. Studies conducted between 2019 and 2022 were chosen. Flavonoids, at concentrations mainly between 2 and 300 μM, are capable of regulating platelet aggregation, blood coagulation, fibrinolysis, and nitric oxide production due to their action on multiple receptors and enzymes. Most of the studies have been carried out through in vitro and in silico models, and limited studies have reported the in vivo and clinical effect of flavonoids. Currently, quercetin has been the only flavonoid evaluated clinically in patients with COVID‐19 for its effect on D‐dimer levels. Therefore, clinical studies in COVID‐19 patients analyzing the effect on platelet, coagulant, fibrinolytic, and nitric oxide parameters are required. In addition, further high‐quality studies that consider cytotoxic safety and bioavailability are required to firmly propose flavonoids as a treatment for the thrombotic complications implicated in COVID‐19.
is study was oriented towards encapsulation of S. rebaudiana extract and the study of its release kinetics. e desired encapsulation was achieved by the ionotropic gelation method using sodium alginate and inulin of polymeric constituents. Characterization of the capsules was performed by micrometric properties, encapsulation efficiency, in vitro extract release analysis, and biological activity of released extract. e in vitro release profiles from different capsules were applied on different kinetic models. e prepared capsules were found spherical in shape with diameters ranging from 2.07 to 2.63 mm, having the encapsulation efficiencies of 43.77% and 56.53% for phenolic compounds and steviol glycosides, respectively. e best-fit model with the highest correlation coefficient was observed in the Ritger-Peppas model, indicating diffusion controlled principle. e release exponent n value obtained from the Korsmeyer-Peppas model varied between 0.2273 and 1.1719, confirming that the mechanism of S. rebaudiana extract bioactive compounds release was diffusion controlled.
Cardiovascular diseases (CVD) are the leading cause of death. The most common cardiovascular pathologies are thromboembolic diseases. The antithrombotic therapy prevents the thrombi formation or dissolves the previously constituted. However,...
scite is a Brooklyn-based organization that helps researchers better discover and understand research articles through Smart Citations–citations that display the context of the citation and describe whether the article provides supporting or contrasting evidence. scite is used by students and researchers from around the world and is funded in part by the National Science Foundation and the National Institute on Drug Abuse of the National Institutes of Health.