Antiplatelet and Anticoagulant Effects of Two New Phenylpropanoid Sucrose Esters and Other Secondary Metabolites from the Aerial Part of Canna edulis

Abstract

This study isolated pure compounds from Canna edulis aerial parts and assessed their antiplatelet and anticoagulant potential. Structural elucidation resulted in the identification of two new compounds: caneduloside A (1) and caneduloside B (2), and eleven known compounds: 6’‐acetyl‐3,6,2’‐tri‐p‐coumaroyl sucrose (3), 6¢‐acetyl‐3,6,2¢‐triferuloyl sucrose (4), tiliroside (5), afzelin (6), quercitrin (7), 2‐hydroxycinnamaldehyde (8), cinnamic acid (9), 3,4‐dimethoxycinnamic acid (10), dehydrovomifoliol (11), 4‐hydroxy‐3,5‐dimethoxybenzaldehyde (12), and (S)‐(‐)‐rosmarinic acid (13). Compounds 3, 4, 6‐9, 13 were previously reported for antithrombotic properties. Hence, antithrombotic tests were conducted for 1, 2, 5, 10‐12. All tested compounds demonstrated a dose‐dependent antiaggregatory effect, and 10 and 12 were the most potent for both ADP and collagen activators. Additionally, 10 and 12 exhibited anticoagulant effects, with prolonged prothrombin time and activated partial thromboplastin time. The new compound 1 displayed antiplatelet and anticoagulant activity, while 2 mildly inhibited platelet aggregation. C. edulis is a potential source for developing antithrombotic agents.

Solubility Behavior, Solvent Effect, and Data Correlation of 3,4-Dimethoxycinnamic Acid in 12 Pure Solvents at Multiple Temperatures

“…8 In 2024, a study showed that DMCA had antiplatelet effects for both ADP and collagen and showed anticoagulant activities. 9 The practical application of chemical substances is always closely related to the interaction between the molecules in the system, and molecular interactions can determine its physical properties such as dissolution, crystal nucleation, and growth. 10,11 However, solubility is a crucial physicochemical characteristic in the crystallization process, which is a key factor in optimizing the crystallization process and predicting the final yield.…”

“…In addition, ferulic acids and various methylated cinnamic acid derivatives, like DMCA, improve cell viability and indirectly increase the expression of various endogenous antioxidant enzymes. , What is more, Zheng et al demonstrated DMCA against adult and larval stages of Plutella xylostella . In 2024, a study showed that DMCA had antiplatelet effects for both ADP and collagen and showed anticoagulant activities …”