Antiplatelet actions of panaxynol and ginsenosides isolated from ginseng

Chen, Teng; Kuo, Sheng‐Chu; Ko, Feng‐Nien; Lee, Jan-Chang; Lee, Lih-Gen; Chen, Sheng‐Chih; Huang, Tur‐Fu

doi:10.1016/s0304-4165(89)80051-0

Cited by 107 publications

(47 citation statements)

References 11 publications

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“…Ginsenoside Rb1 isolated from red ginseng significantly decreased histamine and leukotriene production in a dosedependent manner during mast cell activation [21] as well as lipopolysaccharide-induced proinflammatory cytokine production [43]. Recently, dietary pigment, curcumin appears to block H pylori-induced NF-κB activation, IL-8 gene expression, the cell scattering response [35], and modulate AA metabolism including PLA 2 , COX, and 5-LOX [44].…”

Section: Discussionmentioning

confidence: 99%

“…Based on our previous report that the rescuing action of red ginseng extract (RGE) from H pylori-associated cytotoxicity through the efficient inhibitory actions of both MAPK and repression of redox-sensitive transcription factor [20] and on other's reports showing the influence of ginsenoside isolate or panaxynol isolated from ginseng on either intracellular calcium [21,22] or mediators like COX-2 and nuclear factor (NF)-κB [23,24], we hypothesized that RGE can modulate H pylori-associated gastric inflammation through modulating LOX activities and measured the LOX activities by both reverse phase-high performance liquid chromatography (RP-HPLC) and thin layer chromatography (TLC) and checked its expression by Western blotting in gastric mucosal cells.…”

Section: Abstract Helicobacter Pylori Red Ginseng 5(s)-hete 5-lmentioning

confidence: 99%

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Inhibitory Activities and Attenuated Expressions of 5-LOX with Red Ginseng in Helicobacter pylori-Infected Gastric Epithelial Cells

et al. 2007

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Our recent studies documented that red ginseng extract (RGE, isolates from steamed and dried Panax ginseng, C.A. Meyer) can inhibit Helicobacter pylori-induced mitogen-activated protein kinase (MAPK) signaling with repressing either nuclear factor (NF)-κB-DNA binding activity or releases of IL-8 and COX-2 in gastric epithelial cells (Dig Dis Sci 50:1218-1227, 2005. We extended the experiment to prove whether RGE influences 5-lipoxygenase (5-LOX) pathway, thereby suppressing the biosynthesis of 5(S)-HETE. The 5-LOX enzyme activities were measured by thin layer chromatography using 14 C-labeled arachidonic acid (AA) and quantified by reverse phase-high performance liquid chromatography in human gastric adenocarcinoma (AGS) cells cocultured with H pylori (ATCC 43504 strain) with or without pretreatment of RGE. Western blotting analyses for MAPK signaling and 5-LOX, reverse transcriptase polymerase chain reaction for interleukin-8, and electrophoretic mobility shift assay for NF-κB-DNA binding were done, respectively. H pylori infection increased exclusively 5-LOX enzyme activity and RGE inhibited H pylori-stimulated 5-LOX activity, resulting in suppression of 5(S)-HETE generations from AA. RGE inactivated c-jun phosphorylation and repressed redox-sensitive transcriptional activation, led to reduced expression of IL-8 and 5-LOX mRNA in gastric mucosal cells, of which action was

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Section: Discussionmentioning

confidence: 99%

Section: Abstract Helicobacter Pylori Red Ginseng 5(s)-hete 5-lmentioning

confidence: 99%

Inhibitory Activities and Attenuated Expressions of 5-LOX with Red Ginseng in Helicobacter pylori-Infected Gastric Epithelial Cells

et al. 2007

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“…Falcarinol (1) and falcarindiol (2) have shown anti-inflammatory and anti-plateletaggregatory effects (Teng et al 1989;Appendino et al 1993;Alanko et al 1994). For falcarinol it has been suggested that this pharmacological action is related to the ability of the compound to modulate prostaglandin catabolism by inhibiting the prostaglandincatabolizing enzyme 15-hydroxy-prostaglandin dehydrogenase (Fujimoto et al 1998).…”

Section: Anti-inflammatory Anti-platelet-aggregatory and Antibacterimentioning

confidence: 99%

Acetylenes and Psoralens

Christensen¹,

Brandt²

2006

Plant Secondary Metabolites

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“…Some of the ingredients examined have been reported to have antiplatelet activities. For example, active ingredients of Magnolis officinalis, 22) Corydalis yanhusuo, 21) and Panax ginseng 23,24) have been shown to exert their antiplatelet effect through a mechanism inhibiting thromboxane formation. Magnolia officinalis and Corydalis yuanhusuo have also been shown to exert antiplatelet action through the decrease of intracellular calcium concentration.…”

Section: Fig 5 Effects Of Inducing Platelet Aggregation By Ingrediementioning

confidence: 99%