Inhibitory Activities and Attenuated Expressions of 5-LOX with Red Ginseng in Helicobacter pylori-Infected Gastric Epithelial Cells

Park, Soo‐Jin; Yeo, Myoung-Souk; Jin, Joo-Hyun; Lee, Kee-Myung; Kim, Sung Soo; Choi, Sang Yoon; Hahm, Ki‐Baik

doi:10.1007/s10620-006-9440-6

Cited by 31 publications

(22 citation statements)

References 38 publications

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“…Red ginseng extract has inhibitory 5-LOX enzyme activity and LOX-inhibiting action that suppresses inflammation of H. pylori-infected gastric epithelial cells [162] . Epigallocatechin gallate, one of the green tea catechins, showed significant cytoprotective effects against H. pylori associated gastric cytotoxicity [163] .…”

Section: Eradication: Hope Is Coming?mentioning

confidence: 99%

Antibiotic treatment forHelicobacter pylori: Is the end coming?

Kim

Choi

Chung

2015

WJGPT

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Infection with the Gram-negative pathogen Helicobacter pylori (H. pylori ) has been associated with gastroduodenal disease and the importance of H. pylori eradication is underscored by its designation as a group I carcinogen. The standard triple therapy consists of a proton pump inhibitor, amoxicillin and clarithromycin, although many other regimens are used, including quadruple, sequential and concomitant therapy regimens supplemented with metronidazole, clarithromycin and levofloxacin. Despite these efforts, current therapeutic regimens lack efficacy in eradication due to antibiotic resistance, drug compliance and antibiotic degradation by the acidic stomach environment. Core tip: This article reviews the recent literature describing antibiotic resistance and trends in Helicobacter pylori (H. pylori ) treatment. As there is no effective conventional therapy, new treatments are being developed and bismuth quadruple, sequential, concomitant therapies are recommended as a first-line regimen in regions with high levels of clarithromycin resistance. Quinolones have also been used for H. pylori treatment, although the cure rate has gradually reduced with this approach. New therapeutic directions include probiotic supplementation, tailored therapy, novel agents, and nanotechnology.

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Section: Eradication: Hope Is Coming?mentioning

confidence: 99%

Antibiotic treatment forHelicobacter pylori: Is the end coming?

Kim

Choi

Chung

2015

WJGPT

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“…RGE blocked NOX activity that was enhanced in renal tubular cells exposed to GM. There were several reports demonstrating the antioxidant effect of red ginseng in cancer cells, pancreatic b cells, auditory cells, and gastric epithelial cells, 18,32,37,38 and recent studies showed the attenuation of mitochondrial dysfunction by red ginseng. 39,40 Ginsenoid restored respiratory chain complex activities and aconitase activity in an animal model of focal cerebral ischemia with a decrease in mitochondrial ROS production, 40 suggesting the neuroprotective effect of red ginseng via an integrated process of mitochondrial protection.…”

Section: Effect Of Red Ginseng Extract On Aki H-s Shin Et Almentioning

confidence: 99%

Renoprotective effect of red ginseng in gentamicin-induced acute kidney injury

Shin

Kim

et al. 2014

Laboratory Investigation

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Aminoglycoside-induced nephrotoxicity is one of the prevalent causes of acute kidney injury (AKI). Oxidative stressmediated apoptosis of renal tubular cells is known to be a major mechanism of renal injury. Red ginseng extract (RGE) has been reported to possess antioxidant and immune-modulatory activities. We investigated the effect of RGE on gentamicin (GM)-induced apoptosis and oxidative stress in cultured renal tubular cells and animal model of GM-induced AKI. GM induced the generation of reactive oxygen species (ROS) with an increase in NADPH oxidase (NOX) activity and mitochondrial oxidation in NRK-52E cells that were ameliorated with RGE. GM-induced apoptosis of NRK-52E cells, which was associated with an increased expression of mitochondrial Bax, cytosolic cytochrome c, and cleaved caspase-9 and -3, along with a decrease in bcl-2 expression, was also blocked by RGE. In an animal model of GM-induced AKI, RGE treatment significantly attenuated renal dysfunction, cell apoptosis, and tubular damage. RGE ameliorated ROS production in rats with GM-induced AKI, as demonstrated by an increase in the reduced form of glutathione in renal cortex and a decrease in urinary excretion of 8-hydroxy-2 0 -deoxyguanosine. Our results suggest that RGE protects the kidney from GM-induced AKI via the mechanism of modulation of oxidative stress.

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“…To increase eradication rates of first-line therapy, several clinical trials involving extending treatment duration to more than one week, use of higher doses of per protocol (PP), and/or new antibiotics such as quinolones, use of quadruple therapy, or addition of probiotics, vitamin C, bovine lactoferrin, ginseng, wine, garlic, honey, and cranberry have been carried out [11][12][13][14][15]. Previous studies have suggested that Korean red ginseng 1) inhibits H. pylori colonization, 2) exhibits antioxidative and antiinflammatory effects during H. pylori infection, 3) provides efficient restorative action, 4) inhibits expression of genes associated with generation of volatile sulfur compounds (VSCs), and 5) increases eradication rates in addition to attenuating H. pyloriassociated halitosis [16][17][18][19]. Here, we investigated the effects of supplementation of triple therapy with Korean red ginseng on both H. pylori eradication rates and H. pylori-associated halitosis.…”

Section: Efficacy Of Korean Red Ginseng Supplementation On Eradicatiomentioning

confidence: 99%

Efficacy of Korean Red Ginseng Supplementation on Eradication Rate and Gastric Volatile Sulfur Compound Levels after Helicobacter pylori Eradication Therapy

Lee¹,

Park²,

Choi³

et al. 2010

Journal of Ginseng Research

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This clinical study was performed to evaluate whether supplementation of proton pump inhibitor (PPI)-based triple therapy with Korean red ginseng can enhance Helicobacter pylori (H. pylori) eradication and reduce levels of halitosis-associated volatile sulfur compounds (VSCs) in the stomach. Seventy-six patients were randomized into an eradication regimen-only group (n=45) or an eradication regimen plus 10 weeks of Korean red ginseng supplementation group (n=31). The eradication regimen consisted of PPI b.i.d., clarithromycin 500 mg b.i.d., and amoxicillin 1 g b.i.d.. for seven days. Korean red ginseng supplementation commenced on the last day of the eradication regimen.13 C-urea breath test and halimeter measurements were performed prior to protocol repetition. By intention-to-treat analysis, the H. pylori eradication rate in the Korean red ginseng group (77.4%, 24 of 31) was higher than that in the control group (45.0%, 26 of 45). However, by per protocol analysis, the eradication rate in the Korean red ginseng group was significantly higher than that in the control group (92.3%, 24/26 vs. 69.4%, 26/38; p<0.05). H. pylori infection was significantly associated with increased VSC levels. However, VSC levels decreased significantly in the Korean red ginseng group (p<0.05). In conclusion, supplementation of triple therapy with Korean red ginseng increased the H. pylori eradication rate and led to significant reductions in VSC levels, suggesting the usefulness of this substance in combating H. pylori infection.

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Inhibitory Activities and Attenuated Expressions of 5-LOX with Red Ginseng in Helicobacter pylori-Infected Gastric Epithelial Cells

Cited by 31 publications

References 38 publications

Antibiotic treatment forHelicobacter pylori: Is the end coming?

Antibiotic treatment forHelicobacter pylori: Is the end coming?

Renoprotective effect of red ginseng in gentamicin-induced acute kidney injury

Efficacy of Korean Red Ginseng Supplementation on Eradication Rate and Gastric Volatile Sulfur Compound Levels after Helicobacter pylori Eradication Therapy

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