Antiplasmodial properties of kaempferol-3-O-rhamnoside isolated from the leaves of Schima wallichii against chloroquine-resistant Plasmodium falciparum

Barliana, Melisa Intan; Suradji, Eka W.; Abdulah, Rizky; Diantini, Ajeng; Hatabu, Toshimitsu; Nakajima‐Shimada, Junko; Subarnas, Anas; Koyama, Hiroshi

doi:10.3892/br.2014.271

Cited by 41 publications

(36 citation statements)

References 21 publications

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“…A previous study reported the antimicrobial activity of the hydroalcoholic extract from the S. wallichii bark against Escherichia coli, Pseudomonas aeruginosa and Shigella species (9). Furthermore, our previous study also reported the antiplasmodial properties of S. wallichii and its component, kaempferol-3-O-rhamnoside, against chloroquine-resistant Plasmodium falciparum (10).…”

Section: Discussionmentioning

confidence: 83%

Induction of caspase cascade pathway by kaempferol-3-O-rhamnoside in LNCaP prostate cancer cell lines

Halimah¹,

Diantini²,

Destiani³

et al. 2014

Biomedical Reports

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Abstract.Prostate cancer has become a leading cause of mortality in humans. Previous studies have shown the potential anticancer properties of kaempferol-3-O-rhamnoside in breast cancer cell lines. In the present study, the anticancer potential of kaempferol-3-O-rhamnoside was investigated in LNCaP human prostate cancer cell lines. The inhibition of cell proliferation was investigated using MTT assays, whereas its ability to induce the caspase-cascade pathway was investigated by western blotting. The results showed that kaempferol-3-O-rhamnoside inhibits the proliferation of LNCaP cells in a dose-dependent manner by upregulating the expression of caspase-8, caspase-9, caspase-3 and poly (ADP-ribose) polymerase proteins. Although further studies are required, the results of the present study indicate the potential application of kaempferol-3-O-rhamnoside in cancer treatment. IntroductionCancer has become a significant disease for humans. In the USA alone, there were ~1.6 million new cases and 577,190 predicted mortalities in 2012. Among all types of cancer, prostate cancer is one of the top causes of male cancer fatalities worldwide (1). It is predicted that 233,000 new cases of prostate cancer will occur in America during 2014 (2).Several treatments are available for treatment of prostate cancer, by overcoming the aggressive tumor. These include surgery, radiation, radioactive implants and hormonal therapy. However, the treatment often impacts the quality of life due to side-effects or complications (3). Thus, numerous investigators have focused on discovering novel drugs or treatments. Among all the agents tested, natural products derived from medicinal plants are among the most favorable.In our previous study, kaempferol-3-O-rhamnoside, the major compound found in the ethyl acetate fractions of the Schima wallichii (S. wallichii) Korth. leaves, was isolated and its properties were investigated against breast cancer cell lines. The results indicated that kaempferol-3-O-rhamnoside was favorable for further exploration of its anticancer therapeutic potential (4). Therefore, in the present study the anticancer properties and mechanism of kaempferol-3-O-rhamnoside were investigated in prostate cancer cell lines. Materials and methodsPlant materials. S. wallichii Korth. leaves were collected from Lembang, West Java, Indonesia. The plant species was identified at the Department of Biology, Faculty of Mathematics and Natural Sciences, University of Padjadjaran (West Java, Indonesia).Extraction and isolation. The S. wallichii leaves were dried and extracted with 70% ethanol at room temperature three times for 24 h each. A concentrated extract was obtained in vacuo at 50˚C. The ethanol extract was partitioned into n-hexane, ethyl acetate and aqueous phases. Column chromatography on a Wakogel C 200 (Wako Pure Chemical Industries, Ltd., Osaka, Japan) column was performed to the ethyl acetate fraction, as it was previously reported as the most active fraction against cancer cell lines, using a mixture of n-hexane, ethyl ac...

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Section: Discussionmentioning

confidence: 83%

Induction of caspase cascade pathway by kaempferol-3-O-rhamnoside in LNCaP prostate cancer cell lines

Halimah¹,

Diantini²,

Destiani³

et al. 2014

Biomedical Reports

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“…Medicinal plants contain numerous compounds which serve as potential drug sources for human disease management (Barliana et al, 2014). Some of the medicinal plants that have been previously reported to possess antimalarial activities in folkloric medicine include Lawsonia inermis, Chromolaena odorata and Tithonia diversifolia (Afolayan et al, 2014;Elufioye and Agbedahunsi, 2004;Idowu et al, 2010;Ukpai and Amaechi, 2012).…”

Section: Introductionmentioning

confidence: 98%

Antimalarial actions of Lawsonia inermis, Tithonia diversifolia and Chromolaena odorata in combination

Afolayan

Adegbolagun

Irungu

et al. 2016

Journal of Ethnopharmacology

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“…Flavonoids, saponins, alkaloids, diterpenoids and kaempferol rhamnoside found in various medicinal plants have demonstrated antimalarial activities. [24][25][26][27] Thus the antimalarial activity of Alysicarpus glumaceus methanol extract in P. berghei infected mice might be due to the presence of one or a combination of these phytochemical constituents acting singly or in combination.…”

Section: Resultsmentioning

confidence: 99%

Antimalarial Activity of the Methanol Aerial Extract of Alysicarpus glumaceus (Vahl) DC. in Plasmodium berghei Infected Mice

Olorukooba¹,

Khan²,

Madu³

2019

TJNPR

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Article history:Medicinal plants are a potential source of affordable and effective drugs used in the treatment of many diseases. The plant Alysicarpus glumaceus has been used in traditional medicine for the treatment of many ailments including; thrush, sore, asthma, burn, and fever. The present study was designed to investigate the antimalarial activity of the methanol aerial extract of Alysicarpus glumaceus in Plasmodium berghei infected mice using suppressive, curative and prophylactic models. Phytochemical screening using standard procedures and acute toxicity studies via the oral route in mice were also conducted. Results from the phytochemical screening revealed the presence of glycosides, saponins, tannins, flavonoids, triterpenes, and alkaloids. The oral mean lethal dose (LD50) was estimated to be greater than 5,000 mg/kg in mice. The methanol aerial extract of Alysicarpus glumaceus at doses of 250, 500 and 1,000 mg/kg produced a significant (p<0.05) dose-dependentchemosuppression in the suppressive, curative and prophylactic tests respectively. There was a statistically significantly (p<0.05) prolongation of mean survival time in the extract treated mice in the curative study. The results of this investigation suggest that the methanol aerial extract of Alysicarpus glumaceus contains bioactive constituents with antimalarial activity.

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Antiplasmodial properties of kaempferol-3-O-rhamnoside isolated from the leaves of Schima wallichii against chloroquine-resistant Plasmodium falciparum

Cited by 41 publications

References 21 publications

Induction of caspase cascade pathway by kaempferol-3-O-rhamnoside in LNCaP prostate cancer cell lines

Induction of caspase cascade pathway by kaempferol-3-O-rhamnoside in LNCaP prostate cancer cell lines

Antimalarial actions of Lawsonia inermis, Tithonia diversifolia and Chromolaena odorata in combination

Antimalarial Activity of the Methanol Aerial Extract of Alysicarpus glumaceus (Vahl) DC. in Plasmodium berghei Infected Mice

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