Antiplasmodial Natural Products

Nogueira, Cláudio Rodrigo; Lopes, Lucia Maria Xavier

doi:10.3390/molecules16032146

Cited by 105 publications

(70 citation statements)

References 111 publications

(127 reference statements)

Supporting

Mentioning

Contrasting

Unclassified

Order By: Relevance

“…Flavonoids comprising a large group of polyphenolic secondary metabolites possess antimalarial activities. Triterpenoids including saponins have been found to be active on P. falciparum [3]. The observed antimalarial activity of water extract might also be attributed to the presence of anthraquinones which were absent in the methanol extract.…”

Section: Discussionmentioning

confidence: 99%

See 1 more Smart Citation

In vivo Antimalarial Activity of Methanol and Water Extracts of Eryngium thorifolium Boiss (Apiaceae Family) against P. berghei in Infected Mice

Ural¹,

Kayalar²,

Durmuşkahya³

et al. 2014

Trop. J. Pharm Res

View full text Add to dashboard Cite

Section: Discussionmentioning

confidence: 99%

“…As a result of the recognition of the global importance of fighting against malaria, efforts to discover and develop new antimalarials from plant sources has increased [3].…”

Section: Introductionmentioning

confidence: 99%

In vivo Antimalarial Activity of Methanol and Water Extracts of Eryngium thorifolium Boiss (Apiaceae Family) against P. berghei in Infected Mice

Ural¹,

Kayalar²,

Durmuşkahya³

et al. 2014

Trop. J. Pharm Res

View full text Add to dashboard Cite

“…4 Many others have also been described as active in vitro against the parasite and could become lead compounds with new mechanisms of action in order to overcome resistance. 5 Triterpene-rich plant extracts containing betulinic acid (2a, Figure 2) have been reported as antiplasmodial. Initial evidences of the activity of betulinic acid indicated a moderately action against P. falciparum (NF 54) with IC 50 values (concentration in that the growth of the parasites is 50% inhibited) = 10.5 µg mL -1 .…”

Section: Introductionmentioning

confidence: 99%

Preparation of Derivatives of Betulinic Acid, Steviol and Isosteviol and Evaluation of Antitrypanosomal and Antimalarial Activities

Ullah

Baratto

Paula³

et al. 2016

Journal of the Brazilian Chemical Society

View full text Add to dashboard Cite

Derivatives of steviol, isosteviol and betulinic acid were prepared and tested in vitro against Plasmodium falciparum W2 (chloroquine-resistant) and Trypanosoma cruzi. The best results against P. falciparum were found for the betulinic acid ). The derivatives of betulinic acid were more selective to the parasite when compared with hepatoblastoma HepG2 A16 cells. The results showed that nitrophenylhydrazone derivatives of lupane and beyerane terpenes are promising prototypes of antimalarial agents. Among the compounds tested against T. cruzi the oxime of isosteviol was active against both epimastigote and trypomastigote forms of the parasite.

show abstract

“…The history of malaria has shown that plants are a source of new molecules. This is the case of quinine that has been isolated from Chincona and artemisinin that has been isolated from Artemisia annua (Batista et al, 2009;Bero and Joëlle, 2011;Bero et al, 2009;Kaur et al, 2009;Nogueira and Lopes, 2011;Phillipson and Wright, 1991). Over 80% of the world's population use medicinal plants for healing (WHO, 2008(WHO, , 2010.…”

Section: Introductionmentioning

confidence: 99%

Antiplasmodial activity of Vernonia cinerea Less (Asteraceae), a plant used in traditional medicine in Burkina Faso to treat malaria

Soma¹,

Sanon²,

GansanÃ³

et al. 2017

Afr. J. Pharm. Pharmacol.

View full text Add to dashboard Cite

Research and development of new antiplasmodial molecules in plant is a very important way for the development of new anti-malarial drugs. In this study, Vernonia cinerea Less (Asteraceae) was selected for its promising antiplasmodial activity because it is traditionally used in Burkina Faso to treat malaria. The aim of this study was to investigate the antiplasmodial activity of this whole plant. Five crude extracts of V. cinerea Less were prepared from the solvents of increasing polarity (CH 2 Cl 2 , CH 3 OH, CH 3 OH/H 2 O (1/1), H 2 O and alkaloids extracts). The method of Ciulei (1982) and thin layer chromatography were used for chemical characterization. The p-LDH technique was used in vitro. Extracts were evaluated in vitro for efficacy against the Plasmodium falciparum strain K1, which is resistant to chloroquine, and 3D7, which is sensitive to chloroquine. The crude extracts of alkaloids showed the IC 50 =4.25 μg/ml with the strains 3D7 and IC 50 =2.56 µg/ml with the K1 strains. The CH 2 Cl 2 extracts showed the IC 50 = 8.42 µg/ml and IC 50 =5.85 µg/ml on strains 3D7 and K1, respectively. The CH 3 OH extracts showed the IC 50 =21.08 µg/ml, CH 3 OH/H 2 O extracts gave 41.56 µg/ml and H 2 O extracts gave 37.17 µg/ml on strains of P. falciparum K1. The present study highlighted the very promising antiplasmodial activity of V. cinerea Less. The most antiplasmodial activity of this plant extracts merit further study about its in vivo antiplasmodial activity in Plasmodium berghei infected mice.

show abstract

Antiplasmodial Natural Products

Cited by 105 publications

References 111 publications

<i>In vivo</i> Antimalarial Activity of Methanol and Water Extracts of <i>Eryngium thorifolium</i> Boiss (Apiaceae Family) against <i>P. berghei</i> in Infected Mice

<i>In vivo</i> Antimalarial Activity of Methanol and Water Extracts of <i>Eryngium thorifolium</i> Boiss (Apiaceae Family) against <i>P. berghei</i> in Infected Mice

Preparation of Derivatives of Betulinic Acid, Steviol and Isosteviol and Evaluation of Antitrypanosomal and Antimalarial Activities

Antiplasmodial activity of Vernonia cinerea Less (Asteraceae), a plant used in traditional medicine in Burkina Faso to treat malaria

Contact Info

Product

Resources

About