Antioxidative effects of phenolic extracts from chestnut leaves, catkins and spiny burs in streptozotocin-treated rat pancreatic β-cells

Mujić, Aida; Grdović, Nevena; Mujić, Ibrahim; Mihailović, Mirjana; Živković, Jelena; Poznanović, Goran; Vidaković, Melita

doi:10.1016/j.foodchem.2010.08.068

Cited by 50 publications

(40 citation statements)

References 24 publications

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“…The possible mechanism by which pumpkin brings out its antidiabetic action maybe potentiating and stimulate the insulin secretion from pancreatic β-cells [21]. Another possibility is because the flavonoids can protect the DNA from the oxidative damage, so it can resist the problem in β-cell [22][23][24].…”

Section: Discussionmentioning

confidence: 99%

Antidiabetic Effects of Pumpkin (Cucurbita Moschata Durch) Flesh and Seeds Extracts in Streptozotocin Induced Mice

Marbun

Sitorus

Sinaga

2018

Asian J Pharm Clin Res

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Objective: The present study is to investigate the antidiabetic effect of pumpkin flesh and seeds ethanolic extracts in STZ-induced diabetic mice. Methods:The study begins with making the ethanolic extracts of pumpkin flesh and seeds and then evaluates the physicochemical characterization, phytochemical screening, and induced diabetic mice using STZ.Result: The physicochemical evaluation shows that the extracts had a good and high purity level, while the phytochemical screening showed both pumpkin flesh and seeds extracts have a various of phytoconstituents. The pumpkin flesh and seeds ethanolic extracts (dose level 150 mg/kg) showed a significant reduction of the blood glucose. Conclusion:Pumpkin flesh and seeds ethanolic extracts exhibited significant antidiabetes activity in STZ-induced mice.

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Section: Discussionmentioning

confidence: 99%

Antidiabetic Effects of Pumpkin (Cucurbita Moschata Durch) Flesh and Seeds Extracts in Streptozotocin Induced Mice

Marbun

Sitorus

Sinaga

2018

Asian J Pharm Clin Res

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“…Different solvents such as water (Calliste et al 2004; Barreira et al 2010), methanol (Calliste et al 2004), ethyl acetate (Basile et al 2000;Calliste et al 2004) and ethanol-aqueous solutions (Almeida, Fernandes, et al 2008;Almeida, Valentão, et al 2008;Mujić et al 2011) are suitable agents for the extraction of phenolics from C. sativa leaves, but the polarity of the solvent influences the antioxidant activity of the extract. Ethanol is considered a good solvent for polyphenol extraction and safe for human consumption (Shi et al 2005) being a GRAS (generally recognised as safe) compound.…”

Section: Extraction Methodsmentioning

confidence: 99%

“…According to Opara (2004), antioxidant supplements can be used as adjunct therapy for control of blood sugar in diabetic patients. As such, Mujić et al (2011) studied the capacity of leaf extracts of C. sativa in DNA protection in b-cells. A diabetogenic agent streptozotocin (STZ) was mixed with an ethanolic extract of C. sativa leaves.…”

Section: Chestnut Leaf Extractsmentioning

confidence: 99%

Castanea sativaby-products: a review on added value and sustainable application

Braga

Rodrigues

Oliveira

2014

Natural Product Research

107

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Castanea sativa Mill. is a species of the family Fagaceae abundant in south Europe and Asia. The fruits (chestnut) are an added value resource in producing countries. Chestnut economic value is increasing not only for nutritional qualities but also for the beneficial health effects related with its consumption. During chestnut processing, a large amount of waste material is generated namely inner shell, outer shell and leaves. Studies on chestnut by-products revealed a good profile of bioactive compounds with antioxidant, anticarcinogenic and cardioprotective properties. These agro-industrial wastes, after valorisation, can be used by other industries, such as pharmaceutical, food or cosmetics, generating more profits, reducing pollution costs and improving social, economic and environmental sustainability. The purpose of this review is to provide knowledge about the type of chestnut by-products produced, the studies concerning its chemical composition and biological activity, and also to discuss other possible applications of these materials.

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“…The possible mechanism might be the potentiation of pancreatic secretion of insulin from existing β-cell [19]. Another possibility is because the flavonoids can protect the DNA from the oxidative damage, so it can resist the problem in β-cell [20].…”

Section: Discussionmentioning

confidence: 99%

Phytochemical Screening and Antidiabetic Activity of Different Leaf Extracts From Lotus (Nelumbo Nucifera Gaertn.) in Streptozotocin Induced Mice

Rumanti

Nainggolan

Harahap

2017

Asian J Pharm Clin Res

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Objective: The present study is to evaluate the antidiabetic activity of various extract of Lotus (Nelumbo nucifera Gaertn.) leaf using hexane, ethyl acetate, and ethanol organic solvent.Methods: Standard phytochemical screening method and streptozotocin induced diabetic mice. Result:The phytochemical screening showed only ethyl acetate of lotus leaf extract contains the flavonoids. The ethyl acetate lotus leaf extract (dose level 150 mg/kg) showed a significant reduction of the blood glucose. Conclusion:The ethyl acetate extract of lotus leaf (N. nucifera Gaertn.) had the hypoglycemic effect on diabetic induced mice.

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Antioxidative effects of phenolic extracts from chestnut leaves, catkins and spiny burs in streptozotocin-treated rat pancreatic β-cells

Cited by 50 publications

References 24 publications

Antidiabetic Effects of Pumpkin (Cucurbita Moschata Durch) Flesh and Seeds Extracts in Streptozotocin Induced Mice

Antidiabetic Effects of Pumpkin (Cucurbita Moschata Durch) Flesh and Seeds Extracts in Streptozotocin Induced Mice

Castanea sativaby-products: a review on added value and sustainable application

Phytochemical Screening and Antidiabetic Activity of Different Leaf Extracts From Lotus (Nelumbo Nucifera Gaertn.) in Streptozotocin Induced Mice

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