Antioxidants from Lespedeza homoloba. (I)

Miyase, Toshio; Sano, Mitsuaki; Nakai, Haruko; Muraoka, Miyuki; Nakazawa, Miho; Suzuki, M.; Yoshino, Kyouji; Nishihara, Yunosuke; Tanai, Junichi

doi:10.1016/s0031-9422(99)00195-8

Cited by 66 publications

(44 citation statements)

References 13 publications

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“…It is an addition to the small group of naturally occurring benzils (Ferrari et al, 1984;Miyase et al, 1999;Li et al, 1998) which presumably arise by oxidation of flavonoid precursors. Compounds 2 and 3 are new isoflavones.…”

Section: Resultsmentioning

confidence: 99%

A benzil and isoflavone derivatives from Derris scandens Benth.

et al. 2004

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Section: Resultsmentioning

confidence: 99%

A benzil and isoflavone derivatives from Derris scandens Benth.

et al. 2004

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“…3,[19][20][21] Furthermore, the presence of two hydroxyls, one methoxy, and two 3,3-dimethylallyl substituents was evident from the MS data and NMR spectra (see Experimental Section). Three aromatic proton singlets at δ 7.10, 7.08, and 6.31 appeared in the 1 H NMR spectrum, together with the biogenetically expected oxygenation at C-5, C-7, and C-4′, 1,7,19,21,22 indicating that the 3,3-dimethylallyl groups could be placed at C-6, C-8, or C-5′. This was resolved from the HMBC NMR spectrum, which showed correlations of the H-1′′ at δ 3.41 with C-5 (δ 153.0) and C-7 (δ 156.2); H-8 at δ 6.31 with C-4a (δ 104.6), C-6 (δ 114.3), C-7 (δ 156.2), and C-8a (δ 153.8); and H-2 at δ 5.45 with C-8a, allowing for the location of one 3,3-dimethylallyl group located at C-6.…”

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confidence: 94%

Antibacterial Compounds from Glycyrrhiza uralensis

et al. 2006

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From the roots of Glycyrrhiza uralensis, two new pterocarpenes, glycyrrhizol A (1) and glycyrrhizol B (2), along with four known isoflavonoids, 5-O-methylglycryol (3), isoglycyrol (4), 6,8-diisoprenyl-5,7,4′-trihydroxyisoflavone (5), and gancaonin G (6), were isolated using a bioassay-guided fractionation method. The structures of the new compounds (1 and 2) were elucidated by spectroscopic data interpretation. The known compounds (3-6) were identified by comparison of their spectroscopic data with reported values in the literature. Glycyrrhizol A (1) and 6,8-diisoprenyl-5,7,4′-trihydroxyisoflavone (5) exhibited potent antibacterial activity against Streptococcus mutans with minimum inhibitory concentrations of 1 and 2 µg/mL, respectively, while glycyrrhizol B (2) and gancaonin G (6) showed more moderate activity.

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“…Daidzein and genistein, two major isoflavones in soybean, have received a considerable attention due to their bioactivities beneficial to the human health, including estrogenic (9), anticancer (14), antioxidant (1,21), and cardioprotective (11) activities. Recently, special interest has been focused on the biological effects of the daidzein metabolites, which are being actively studied for drug development (5,16).…”

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confidence: 99%