A benzil and isoflavone derivatives from Derris scandens Benth.

Derris scandens Benth Extract Potentiates Radioresistance of Hep-2 Laryngeal Cancer Cells

“…A variety of biological active compounds have been identified from the extract of this plant. The major active constituents of D. scandens are benzyls and isoflavones, including genistein, coumarins, scandinone, scandenin, prenylated isoflavones, and isoflavone glycosides (Rukachaisirikul et al, 2002;Laupattarakasem et al, 2004;Mahabusarakam et al, 2004;Rao et al, 2007). The main compounds showing intestinal α-glucosidase inhibitory and free radical scavenging activity are scandinone, scadenone, scandenin A, scandenin B, and 4', 5', 7-trihydroxybiprenyl isoflavone (Rao et al, 2007).…”

Phytochemical investigation and antimicrobial activity of Derris scandens

“…Previous studies indicated the presence of coumarins, isoflavones, flavones, isoflavone glycosides and phenyl coumarins as chemical constituents from D. scandens (Sreelatha et al, 2010;Mahabusarakam et al, 2004). Now we are reporting two coumarins (1 and 2), four triterpenes (3-6), and two steroids (7 and 8) from the roots and stems extracts of D. scandens.…”

“…(family Leguminosae) is distributed in South East Asia and North Australia (Mahabusarakam et al, 2004). Its stem is widely used in traditional medicine as an anti-tussive, diuretic, expectorant and anti-dysentery agent and for treatment of muscle pains (Mahabusarakam et al, 2004), cough and diarrhea (Sreelatha et al, 2010). Insecticidal constituents, viz., rotenone and lonchocarpic acid, were reported also from the roots of D. scandens, and these compounds demonstrated insect anti-feedant activity (Rani et al, 2013).…”

Efficacy and safety of Derris scandens (Roxb.) Benth. for musculoskeletal pain treatment: A systematic review and meta-analysis of randomized controlled trials

“…and leukotriene-B4 (LTB4) generation in the same manner, similar AEs of both can be produced (Wongsinkongman et al, 2013;Kuptniratsaikul et al, 2011;Mahabusarakam et al, 2004;Laupattarakasem et al, 2004). In Thailand National List of Essential Medicines (NLEMs), D. scandens should be used with caution in peptic ulcer patients because it may irritate the gastrointestinal mucosa.…”

“…scandens extract exhibited good anti-inflammatory effect by inhibition of cyclooxygenase 1 (COX-1) and leukotriene-B4 (LTB4) generation, reduction of eicosanoid synthesis via both cyclooxygenase and lipoxygenase pathways and myeloperoxide release (Wongsinkongman et al, 2013;Kuptniratsaikul et al, 2011;Mahabusarakam et al, 2004;Laupattarakasem et al, 2004).…”