Efficacy and safety of Derris scandens (Roxb.) Benth. for musculoskeletal pain treatment: A systematic review and meta-analysis of randomized controlled trials

Puttarak, Panupong; Sawangjit, Ratree; Chaiyakunapruk, Nathorn

doi:10.1016/j.jep.2016.09.021

Cited by 24 publications

(11 citation statements)

References 17 publications

Supporting

Mentioning

Contrasting

Order By: Relevance

“…In Thailand, it has been used traditionally for pain treatment. [ 1 ] Phytochemical studies of the plant have shown that its stems contain various bioactive compounds, such as flavonoids and terpenoids. [ 2 ] Among these compounds, the isoflavone genistein was determined to exhibit anti-inflammatory activity.…”

Section: Introductionmentioning

confidence: 99%

Quantitative analysis of triterpene lupeol and anti-inflammatory potential of the extracts of traditional pain-relieving medicinal plants Derris scandens, Albizia procera, and Diospyros rhodocalyx

Somwong

Theanphong

2021

J Adv Pharm Technol Res

View full text Add to dashboard Cite

A BSTRACT Derris scandens , Albizia procera , and Diospyros rhodocalyx have traditionally been used as herbal remedies for pain relief in Thailand. The ethanolic extracts of these plants obtained by Soxhlet extraction were analyzed by the developed high-performance liquid chromatography-diode-array detection method. Lupeol, the anti-inflammatory triterpene, was selected as a chemical marker for this investigation. All extracts together with that compound were further evaluated for their potential on anti-inflammatory activity using 5-lipoxygenase inhibition assay. Lupeol in each extract was quantified and expressed in the range of 21.44 ± 0.89–40.72 ± 0.40 mg per 100 g of crude drug and the enzyme inhibitory activity of all tested extracts presented as half-maximal inhibitory concentration values ranged between 63.71 ± 2.09 and 91.09 ± 1.40 μg/mL. This study shows that the developed analytical method is effective for analyzing triterpene lupeol in these plants and also reveals the relationship between a lupeol content and the anti-inflammatory effect.

show abstract

Section: Introductionmentioning

confidence: 99%

Quantitative analysis of triterpene lupeol and anti-inflammatory potential of the extracts of traditional pain-relieving medicinal plants Derris scandens, Albizia procera, and Diospyros rhodocalyx

Somwong

Theanphong

2021

J Adv Pharm Technol Res

View full text Add to dashboard Cite

show abstract

“…4 The crude drug of D. scandens stem was also reported that it significantly reduced muscle pain in patients with osteoarthritis and low back pain, with the similar adverse reactions to that of NSAIDs. 3,20,21 Moreover, chloroform extract of leaf and root and aqueous extract of stem of D. scandens exhibited anti-inflammatory activity in the carrageenan-induced paw oedema in rat model and they inhibited eicosanoid inflammatory mediator. 22,23 For Clinical studied found that there were no differences in efficacy and safety in the treatments of knee osteoarthritis with D. scandens crude for seven consecutive days and ibuprofen.…”

Section: Discussionmentioning

confidence: 99%

Anti-Inflammatory Activity and Quantitative Analysis of Major Compounds of the Mixtures of Derris scandens (DZSS) Formula

Ayameang¹,

Rattarom²,

Mekjaruskul³

et al. 2020

View full text Add to dashboard Cite

The mixtures of Derris scandens (DZSS) formula is a Thai traditional medicine, which consists of Derris scandens (Roxb.) Benth. (Fam.Leguminosae-Papilioideae) (D), Zingiber cassumunar Roxb. (Fam.Zingiberaceae) (Z), Suregada multiflora Baill. (Fam.Euphorbiaceae) (S) and Siphonodon celastrineus (Fam.Celastraceae) (S). According to the Thai National List of Essential Herbal Medicine (2013), there are two traditional formulas of DZSS formula, DZSS1 and DZSS2, which contains a different amount of Zingiber cassumunar Roxb. rhizome. The ratios of 4 herbs (D:Z:S:S) in the DZSS1 and DZSS2 formulas are 1:1:1:1 and 1:2:1:1, respectively. 1,2 The DZSS formula has been traditionally used for relieving muscle pain. The formula is given orally at the dosage of 900-1,500 mg three times a day immediately after a meal. This medicinal herb formula is contraindicated in pregnant women and should be carefully used in patients with peptic ulcer since D. scandens showed a similar mechanism of anti-inflammation as that of non-steroidal anti-inflammatory drugs (NSAIDs) with an inhibition against prostaglandin production. 1,2 Gastrointestinal side effects are thus the major disadvantage of the oral DZSS formula. It is therefore interesting to develop the DZSS formula in a topical dosage form. Previously literature reviewed on the subject of single ingredients of the DZSS formula indicated the presence of coumarins, isoflavones, flavones, isoflavone glycosides and phenyl coumarins as chemical constituents from D. scandens. 3-5 D. scandens, has been used in Ayurvedic, Thai and Chinese herbal medicine to treat a variety of painrelated conditions, including muscle pain, joint pain, arthritis and headaches. Dalpanitin and vicenin-3, two of the flavonoids isolated from D. scandens gave MICs of 23 μg mL-1 against S. aureus. Dalpanitin also exhibited relevant MICs on Gramnegative bacteria (94 μg mL-1 against Escherichia coli and Pseudomonas aeruginosa). 6 For the Thai traditional medicine, volatile oil from Z. cassumunar has been used directly apply and penetrate on the skin for remedied for muscle stress and joint pain. 7 Four phenylbutanoids including (E)-4(3´,4´dimethoxyphenyl)but-3-en-1-ol (compound D), (E)-(3´,4´-dimethoxyphenyl)but-3-en-1-yl acetate (D-acetate), (E)-1(3,4-dimethoxyphenyl)butadiene (DMPBD) and (E)-3(3´,4´-dimethoxyphenyl)-4-[(E)-3´,4´-dimethoxystyr yl]cyclohex1-en (DMPDMS) that isolated from Z. cassumunar extract. 8,9 The stem of S. multiflora and S. celastrineus have been used for treatment of skin disease. The bark of S. multiflora found chemical constituents such as two ent-kaurene diterpenes, ent-16-kaurene-3β,15β,18-triol and ent-3-oxo-16-kaurene-15β,18-ABSTRACT Background: The mixtures of Derris scandens (DZSS) formula is a Thai traditional medicine, which consists of 4 medicinal plants, including Derris scandens (Roxb.) Benth. (D) Zingiber cassumunar Roxb. (Z), Suregada multiflora Baill. (S) and Siphonodon celastrineus (S). The DZSS formula has been used in an oral dosage form for the treatment of muscle pain. However...

show abstract

“…Zhang et al [ 21 ] demonstrated that acupuncture analgesia is effective in reducing pain. In Thailand, Derris scandens has been widely used to reduce musculoskeletal pain [ 22 ].…”

Section: Discussionmentioning

confidence: 99%

Efficacy of Cabbage Leaf versus Cooling Gel Pad or Diclofenac Gel for Patients with Knee Osteoarthritis: A Randomized Open-Labeled Controlled Clinical Trial

Chobpenthai

Arunwatthanangkul

Mahikul

2022

Pain Research and Management

View full text Add to dashboard Cite

Background. Osteoarthritis (OA) is one of the most common joint degeneration ailments adversely affecting the elderly population by impairing their physical movements and quality of life. This study aimed to establish the efficacy of cabbage leaf application in alleviating pain-related distress and positively improving OA conditions. Materials and Methods. Patients with moderate to severe (grades 3-4) OA by the Kellgren and Lawrence grading system with a poor to good Oxford Knee Score were selected for enrollment in this clinical trial. The participants were divided into three intervention groups: the cooling gel pad group for 20 minutes duration once a day (n = 20), the diclofenac gel group for 4 times a day (n = 20) as the control group (total n = 40), and the cabbage leaf group for 1-hour duration once a day (n = 20) as the experimental group (total n = 20). All trial participants were trained to record their Numerical Rating Scale (NRS) pain score and Oxford Knee Score and were advised to undergo weekly follow-ups and assessment of the outcome at 4 weeks. Data were analyzed by the paired t-test and analysis of variance (ANOVA). Results. The cabbage leaf group and cooling gel pad group showed a significant difference in both the Oxford Knee Score ( p < 0.001 in both groups) and NRS score ( p < 0.001 in both groups) before and after the intervention, by using the paired t-test. The three study procedures were found to be significantly different with respect to both the Oxford Knee Score ( p = 0.012 ) and NRS score ( p < 0.001 ), by using ANOVA. Conclusion. This study clinically demonstrated that cabbage leaf application and cooling gel pad application showed similar improvements in reducing OA symptoms in terms of the overall NRS score and Oxford Knee Score. Their therapeutic effectiveness was better than that of diclofenac gel.

show abstract

Efficacy and safety of Derris scandens (Roxb.) Benth. for musculoskeletal pain treatment: A systematic review and meta-analysis of randomized controlled trials

Cited by 24 publications

References 17 publications

Quantitative analysis of triterpene lupeol and anti-inflammatory potential of the extracts of traditional pain-relieving medicinal plants Derris scandens, Albizia procera, and Diospyros rhodocalyx

Quantitative analysis of triterpene lupeol and anti-inflammatory potential of the extracts of traditional pain-relieving medicinal plants Derris scandens, Albizia procera, and Diospyros rhodocalyx

Anti-Inflammatory Activity and Quantitative Analysis of Major Compounds of the Mixtures of Derris scandens (DZSS) Formula

Efficacy of Cabbage Leaf versus Cooling Gel Pad or Diclofenac Gel for Patients with Knee Osteoarthritis: A Randomized Open-Labeled Controlled Clinical Trial

Contact Info

Product

Resources

About