Antibacterial Compounds from Glycyrrhiza uralensis

Abstract

From the roots of Glycyrrhiza uralensis, two new pterocarpenes, glycyrrhizol A (1) and glycyrrhizol B (2), along with four known isoflavonoids, 5-O-methylglycryol (3), isoglycyrol (4), 6,8-diisoprenyl-5,7,4′-trihydroxyisoflavone (5), and gancaonin G (6), were isolated using a bioassay-guided fractionation method. The structures of the new compounds (1 and 2) were elucidated by spectroscopic data interpretation. The known compounds (3-6) were identified by comparison of their spectroscopic data with reported values in the literature. Glycyrrhizol A (1) and 6,8-diisoprenyl-5,7,4′-trihydroxyisoflavone (5) exhibited potent antibacterial activity against Streptococcus mutans with minimum inhibitory concentrations of 1 and 2 µg/mL, respectively, while glycyrrhizol B (2) and gancaonin G (6) showed more moderate activity.

Antioxidant and Antibacterial Activities of Glycyrrhiza uralensis Fisher (Jecheon, Korea) Extracts Obtained by various Extract Conditions

“…유럽계 감초인 G. glabra는 glabridin 성분이 주요 성분으로 함유되어 있고 현재 기능성 미백 소재인 유용성 감초 추출물로 고시되어 있다 [10]. 감초의 주성분으로는 glycyrrhizin과 플라보노이드인 liquiritin, liquiritigenin 및 isoliquiritigenin 등과 아이소플 라보노이드인 licoricidin 등이 보고되고 있고 [11], 감초 추출물은 항산화 활성, 면역 증강 및 항균 활성 등이 있는 것으로 보고되고 있다 [12][13][14]. 본 연구에 앞서 저자들은 국내산 농산물의 수입대체 목적으로 국가별(한국, 중국 및 우즈베키스탄) 감초의 항산화 활성을 비교 분석하여 보고한 바 있다.…”

Development and evaluation of a safe and effective sugar‐free herbal lollipop that kills cavity‐causing bacteria

“…Following our previous discovery [15] that a specific licorice extract has strong antimicrobial activity against cavity-causing bacteria due to the existence of a highly potent antimicrobial compound, Glycyrrhizol A, we aimed to develop a sugar-free candy supplemented with licorice extracts to promote oral health. In order to achieve this goal, we first needed to produce effective licorice extracts in large quantity, and in a safe manner.…”

“…Most importantly, instead of using toxic organic solvents described in the previous paper [15], we successfully developed a new protocol to achieve the same effect by using food-grade ethanol.…”

“…In a previous study, we generated a herbal extract from the roots of Glycyrrhiza uralensis, and the extract showed strong bacteriocidal effects against cavity-causing bacteria like S. mutans. Further studies led to the discovery of a novel compound, Glycyrrhizol A, which is responsible for this bio-activity [15]. In the current study, we aimed to produce the effective herbal extract in large quantity, and use this extract to develop a sugar-free lollipop that could effectively kill cavity-causing bacteria like S. mutans in vitro.…”

In Vitro Antibacterial Effects of Gagam-seopyoungjeon Aqueous Extracts and Their Combination Effects with Clindamycin against Gardnerella Vaginalis

“…세균성 질증의 한의학적 치료에 대한 연구로는 蛇床子洗方 28) , 淸帶湯 29) , 完帶 湯 30) 등이 있었는데 아직까지 加減攝營 煎에 대한 연구는 없었다. 또한, 구성 약 물 중 白芍藥 31) , 白朮 32) , 山藥(炒) 33) , 續 斷(炒) 34) , 地楡, 乾薑(炒黑), 川芎 35,36) , 當 歸 37,38) , 烏梅 및 炙甘草 [39][40][41] an international collaborative study.…”