Antioxidants and α-glucosidase inhibitors from Ipomoea batatas leaves identified by bioassay-guided approach and structure-activity relationships

Zhang, Lu; Tu, Zong–cai; Yuan, Tao; Wang, Hui; Xie, Xing; Fu, Zhifeng

doi:10.1016/j.foodchem.2016.03.079

Cited by 117 publications

(102 citation statements)

References 30 publications

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“…The total phenolic content (TPC) of different crude extracts and fractions was measured by the Folin-Ciocalteau method using a microplate reader (Biotek, Vermont, USA) as previous report (Zhang et al, 2016). The TPC was calculated from a calibration curve plotted using gallic acid as standard, and results were expressed as mg of gallic acid equivalents per gram of extract (mg GAE/g E.).…”

Section: Determination Of Total Phenolic Contentmentioning

confidence: 99%

“…The strongest antioxidant potential of EAF could be due to the highest TPC ( Fig. 1), phenolic compounds like phenolic acid, tannins and flavonoids are one of the main group of compounds acting as antioxidants in plants (Tabata et al, 2008;Zhang et al, 2015a;Zhang et al, 2016). Besides that, a number of phenolic acids, tannins (such as geraniin, corilagin, ellagic acid), kaempferol and apigenin derivatves have been identified or tentatively identified from APT and APA, most of them have been widely reported to show excellent antioxidant activity.…”

Section: Antioxidant Activitiesmentioning

confidence: 99%

“…What's more, about 20% of the drugs used worldwide come from plants (Zengin, 2016). Tannins, phenolic acids, flavonoids, terpenoids, alkaloids and steroids are generally considered as the major bioactive constituents in plants (Bueno et al, 2014;Sousa et al, 2016;Zhang et al, 2016). Until now, enormous efforts have been performed to discover novel, safe and non-toxic plant sources or plant-derived natural compounds as alternative or complementary medicines for the treatment of various chronic diseases (Chang et al, 2016;Kumar et al, 2015).…”

Section: Introductionmentioning

confidence: 99%

“…However, synthetic inhibitors, such as acarbose and miglitol, have serious undesirable adverse effects, such as flatulence, diarrhea and serious hepatitis (Carrascosa et al, 1997;Diaz-Gutierrez et al, 1998). At this point, effective, non-toxic and inexpensive ␣-glucosidase inhibitors derived from plant sources were reported to be more acceptable to consumers, and the significance is increasing all over the world (Kalra, 2014;Ma et al, 2015;Zhang et al, 2016).…”

Section: Introductionmentioning

confidence: 99%

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Antihyperglycemic, antioxidant activities of two Acer palmatum cultivars, and identification of phenolics profile by UPLC-QTOF-MS/MS: New natural sources of functional constituents

Zhang

Xie

et al. 2016

Industrial Crops and Products

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Section: Determination Of Total Phenolic Contentmentioning

confidence: 99%

Section: Antioxidant Activitiesmentioning

confidence: 99%

Section: Introductionmentioning

confidence: 99%

Section: Introductionmentioning

confidence: 99%

See 2 more Smart Citations

Antihyperglycemic, antioxidant activities of two Acer palmatum cultivars, and identification of phenolics profile by UPLC-QTOF-MS/MS: New natural sources of functional constituents

Zhang

Xie

et al. 2016

Industrial Crops and Products

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“…Antioxidant activity of methanol extract was evaluated using DPPH scavenging ability assay, which was conducted in a 96-well plate according to previously used method zhang lu et al, 17 with slight modification. Samples in different concentrations (100, 250, 500, 1000, 1500, 2000 ppm) and 0.114 mM DPPH solution 180 µL in methanol were added to each well.…”

Section: Antioxidant Activitymentioning

confidence: 99%

Pharmacognosy, Phytochemical Study and Antioxidant Activity of Sterculia rubiginosa Zoll. Ex Miq. Leaves

Prastiwi

Elya²,

Sauriasari³

et al. 2018

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Original Article INTRODUCTIONIndonesia Nation is rich in flora diversity. Many native plants of Indonesia that still need development for treatment, one of them from the genus Sterculia. The genus was present in tropical and sub-tropical regions, with a number of species 1100. The tree or shrub with simple leaves with flat or toothed edges, unisexual flowers, with 5 petals, some of which have an unpleasant odor as an example of Sterculia foetida in Indonesia is known by the name of Kepuh. There is no report about pharmacognosy and phytochemical study with this plant.Objective: The main aim of this research is to establish pharmacognosy, phytochemical study and antioxidant activity of Sterculia rubiginosa Zoll.ex. Miq. Leaves. The plant used to cure many diseases of Indonesia. Methods: In the present study, pharmacognosy and phytochemical study of plant material were performed as per the Indonesian Herb Pharmacopoeia. Results: Microscopy powder of Sterculia rubiginosa Zoll.ex. Miq. Leaves shows star shape trichoma as a specific fragment. Physicochemical parameters including total ash (17.152 %), acid-insoluble ash (0.922 %), water-soluble extractive (1.610 % w/w), alcohol-soluble extractive (4.524 % w/w), hexane-soluble extractive (4.005 % w/w), and ethyl acetate-soluble extractive (3.160 % w/w) were evaluated. Phytochemical screening of ethanol extracts showed the presence of tannins, flavonoids, alkaloids, steroids-terpenoids, glycosides, and phenols. And absent of saponins and Anthraquinones. Antioxidant activity with IC 50 157, 4665 ppm and flavonoid total was 59.436 mg/g quercetin equivalent. Conclusion: The pharmacognosy, physiochemical, and phytochemical evaluation provides information for the safety, identification, and class of chemical constituent's presents in this crude extract.

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Bioevaluation of synthetic pyridones as dual inhibitors of α‐amylase and α‐glucosidase enzymes and potential antioxidants

Saleem

Khan

Ullah

et al. 2022

Archiv der Pharmazie

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Herein, a library of novel pyridone derivatives 1-34 was designed, synthesized, and evaluated for α-amylase and α-glucosidase inhibitory as well as antioxidant activities. Pyridone derivatives 1-34 were synthesized via a one-pot multicomponent reaction of variously substituted aromatic aldehydes, acetophenone, ethyl cyanoacetate, and ammonium acetate in absolute ethanol. Synthetic compounds 1-34 were structurally characterized by different spectroscopic techniques. Most of the tested compounds showed more promising inhibition potential than the standard acarbose (IC 50 = 14.87 ± 0.16 µM) but compounds 13 and 12 were found to be the most potent compounds with IC 50 values of 9.20 ± 0.14 µM and 3.05 ± 0.18 µM against α-amylase and α-glucosidase enzymes, respectively. Compounds 1-34 also displayed moderate antioxidant potential in the range of IC 50 = 96.50 ± 0.45 to 189.98 ± 1.00 µM in comparison to the control butylated hydroxytoluene (BHT) (IC 50 = 66.50 ± 0.36 µM), in DPPH radical scavenging activities. Additionally, all synthetic derivatives were subjected to a molecular docking study to investigate the interaction details of compounds 1-34 (ligands) with the active site of enzymes (receptors). These results indicate that the newly synthesized pyridone class may serve as promising lead candidates for controlling diabetes mellitus and as antioxidants.

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Antioxidants and α-glucosidase inhibitors from Ipomoea batatas leaves identified by bioassay-guided approach and structure-activity relationships

Cited by 117 publications

References 30 publications

Antihyperglycemic, antioxidant activities of two Acer palmatum cultivars, and identification of phenolics profile by UPLC-QTOF-MS/MS: New natural sources of functional constituents

Antihyperglycemic, antioxidant activities of two Acer palmatum cultivars, and identification of phenolics profile by UPLC-QTOF-MS/MS: New natural sources of functional constituents

Pharmacognosy, Phytochemical Study and Antioxidant Activity of Sterculia rubiginosa Zoll. Ex Miq. Leaves

Bioevaluation of synthetic pyridones as dual inhibitors of α‐amylase and α‐glucosidase enzymes and potential antioxidants

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