Antioxidant vitamin status of obese patients in terms of the risk of comorbidities

Коденцова, В М; Митрофановна, Коденцова Вера; Vrzhesinskaya, O.A.; Александровна, Вржесинская Оксана; Кошелева, О В; Васильевна, Кошелева Ольга; Beketova, N A; Алексеевна, Бекетова Нина; Sharafetdinov, Khaider Khamzyarovich; Хамзярович, Шарафетдинов Хайдерь

doi:10.14341/omet10144

Cited by 3 publications

(1 citation statement)

References 17 publications

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“…Как известно, злоупотребление алкоголем и несбалансированный рацион питания, недостаток витаминов и антиоксидантов являются ведущими факторами риска развития метаболических нарушений и, в том числе, острого алкогольно-алиментарного панкреатита [15][16][17].…”

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The risk of severe acute pancreatitis depending on the genetic predisposition and diet

Samgina,

Kochetova

2024

jour

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The aim of the study: to determine the influence of genetic predisposition and diet on the risk of severe acute pancreatitis (АР). Materials and methods. The results of diagnostics and treatment of 547 patients with acute pancreatitis were analyzed, 97 of them had a severe АР. Patients' blood DNA samples were used as research material. Detailed questionnaire on nutrition was carried out, the qualitative and quantitative composition of the food consumed was assessed. Genomic DNA was isolated using the standard PCE method. Genotyping was performed on a MALDI-TOF MassARRAY-4 analyzer. The role of the following polymorphic variants was studied: SPINK1 C>T (rs6580502), PRSS1 C>T (rs10273639), CFTR A>G (rs213950), TNF -308 G>A (rs1800629), IL1B A>G (rs16944), IL5 A>G (rs2069812), IL6 G>C (rs1800795), IL10 T>C (rs1800896), CETP G>A (rs708272) and LPL T>G (rs320). Statistical analysis was performed using SNPStats and Statistica 10.0 software. Results. In our study, we found that carriers of A/A rs2069812 IL5, G/G-G/C rs1800795 IL6 and T/T rs320 LPL genotypes increased the risk of severe acute pancreatitis. Alcohol abuse increases the risk of severe disease in carriers of T/T SPINK1 (rs6580502) and A/A CFTR (rs213950) genotypes. Constant exposure to alimentary risk factor manifested by increased consumption of fatty foods increases the risk in carriers of G/A-A/A rs 16944 IL1B, reduced protein and carbohydrate intake with food - in carriers of G/A-A/A rs2069812 IL5, carbohydrate - in carriers of G/A-A/A rs708272 CETP. Conclusion. Predictive diagnostics plays an important role in the prevention of severe acute pancreatitis, eliminating the effects of risk factors in carriers of genotypes associated with a severe course of the disease will make it possible to achieve positive success in the prevention of AP, to reduce the frequency of complications and the development of its severe course, to reduce mortality.

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The risk of severe acute pancreatitis depending on the genetic predisposition and diet

Samgina,

Kochetova

2024

jour

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Substantiation of approaches to the correction of lipid metabolism disorders and non-alcoholic fatty liver disease in children with exogenous obesity

et al. 2022

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BACKGROUND: According to the involvement of oxidative stress in the pathogenesis of obesity, the plasma level of coenzyme q10 in the correlation relationship with lipid metabolism disorders and functional liver state is of interest to study.AIM: Substantiation of approaches to the correction of lipid metabolism disorders and non-alcoholic fatty liver disease in children with exogenous obesity based on the content of coenzyme Q10 and its relationship with lipid profile and liver enzymes.MATERIALS AND METHODS: The single-center cross-sectional study enlisted the control (n=32, -1.0≤BMI SD score ≤+2.0) and obese (n=40, BMI SD score>+2.0) groups of children with the mean age of 12 yr. In all children BMI, lipidogram, liver enzymes (ALT and AST), plasma coenzyme Q10 and liver ultrasound examination were assessed.RESULTS: Patients of both groups were comparable (p> 0.05) in age and gender. The level of coenzyme Q10 in the compared groups was comparable (p> 0.05) and did not differ in patients with different degrees of obesity. According to the results of the study of the lipid profile in the obese children, the level of HDL was lower, and the level of LDL was higher than that in control group. The highest value of HDL was obtained in the patients with the 1st degree of obesity and the highest level of triglycerides — in the patients with the 4th degree of obesity. The control group demonstrated moderate correlations between endogenous coenzyme Q10 and total cholesterol (r=0.474, p=0.009) which persists in patients with the first degree of obesity (r = 0.548, p = 0.035). There was no difference in AST in the study groups, however, the main group demonstrated elevated ALT and ALT/AST ratio (p <0.001). The highest ALT and ALT / AST ratio were observed in patients with greatest degree of obesity. Eighteen obese children (45%) had ALT / AST ratio ≥1 (in the control group –one patient (3%) (p <0.001), while fourteen patients showed liver enlargement and structure change according to ultrasound (80%). The control group demonstrated moderate correlations between endogenous coenzyme Q10 and total cholesterol (r=0.474, p=0.009) and between coenzyme Q10 and ALT / AST ratio (r=0.412, p=0.023) . In the obese group there was correlation between AI and ALT / AST (r = 0.436, p = 0.006) and in patients with the 1st degree of obesity — between also coenzyme Q10 and ALT (r = 0.875, p <0.001).CONCLUSION: The disturbances in adequate control of cholesterol by coenzyme Q10 in obese children possibly confirming the involvement of oxidative stress in the pathogenesis of dyslipidemia and non-alcoholic fatty liver disease can serve as indication to use coenzyme Q10 in order to correct these complications.

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The joint contribution of the GGT1 gene and some haploand phenotypes to the development of acute biliary pancreatitis

Samgina

2023

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He aim of the study was to determine the role of polymorphisms of the GGT1 gene and environmental risk factors in the acute biliary pancreatitis. The material of the study was DNA samples obtained from 84 patients with ABP and 573 healthy individuals. The disease was diagnosed using clinical guidelines (Russian Society of Surgeons). To assess the associations of alleles and genotypes of the gene with the risk of acute pancreatitis, the χ2 test and the odds ratio (OR) with 95% confidence intervals (CI) were used. Statistical analysis was carried out using the Statistica 10.0 program (StatSoft, USA) and the SNPStats program. Results. It was found that the A/A-G/G rs5760489 and A/A rs4820599 GGT1 genotypes have an increased risk of ABP. The H3 A-A-A-A haplotype is associated with a reduced risk of the disease, while the H6 A-G-A-A haplotype, on the contrary, increases the risk of developing the disease. The absence of exposure to alcohol abuse reduces the risk of ABP in carriers of the genotypes A/G-G/G rs5760489, A/G-G/G rs4820599, smoking -A/G-G/G rs4820599 and A/G-G/G rs5760489. The A/G-G/G rs4820599, G/A-A/A rs5751909 and A/G-G/G rs5760489 genotypes have a protective effect with sufficient consumption of fresh vegetables and fruits, the main suppliers of glutathione to the body. The presence of glutathione deficiency leads to the oxidative stress, and phenotypic changes we found: leukocytosis (allele A, rs5760489), peritonitis (allele A, rs5751909). Conclusion. The GGT1 gene can be used to predict the development and clinical course of acute biliary pancreatitis and its complications.

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Antioxidant vitamin status of obese patients in terms of the risk of comorbidities

Cited by 3 publications

References 17 publications

The risk of severe acute pancreatitis depending on the genetic predisposition and diet

The risk of severe acute pancreatitis depending on the genetic predisposition and diet

Substantiation of approaches to the correction of lipid metabolism disorders and non-alcoholic fatty liver disease in children with exogenous obesity

The joint contribution of the GGT1 gene and some haploand phenotypes to the development of acute biliary pancreatitis

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