Antioxidant status and lipid peroxidation in the blood of breast cancer patients of different ages after chemotherapy with 5-fluorouracil, doxorubicin and cyclophosphamide

Kasapović, Jelena; Pejić, Snežana; Stojiljković, Vesna; Todorović, Ana; Radošević-Jelić, Ljiljana; Saičić, Zorica S.; Pajović, Snežana B.

doi:10.1016/j.clinbiochem.2010.08.009

Cited by 82 publications

(70 citation statements)

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“…67 Furthermore, breast cancer patients show systemic evidence of increased oxidative stress and a decreased anti-oxidant defense, which increases with aging and tumor progression. [68][69][70] Chemotherapy and radiation therapy then promote further oxidative stress. 69 Unfortunately, "sub-lethal" doses of oxidative stress during cancer therapy may contribute to tumor recurrence and metastasis, via the activation of myofibroblasts.…”

Section: ©2 0 1 1 L a N D E S B I O S C I E N C E D O N O T D I S Tmentioning

confidence: 99%

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Cancer cells metabolically "fertilize" the tumor microenvironment with hydrogen peroxide, driving the Warburg effect

et al. 2011

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Section: ©2 0 1 1 L a N D E S B I O S C I E N C E D O N O T D I S Tmentioning

confidence: 99%

“…[68][69][70] Chemotherapy and radiation therapy then promote further oxidative stress. 69 Unfortunately, "sub-lethal" doses of oxidative stress during cancer therapy may contribute to tumor recurrence and metastasis, via the activation of myofibroblasts.…”

Section: ©2 0 1 1 L a N D E S B I O S C I E N C E D O N O T D I S Tmentioning

confidence: 99%

Cancer cells metabolically "fertilize" the tumor microenvironment with hydrogen peroxide, driving the Warburg effect

et al. 2011

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“…[32][33][34] Several independent lines of evidence now suggest that hydrogen peroxide may function as the "fertilizer" in this process, by driving accelerated aging, DNA damage, inflammation and cancer metabolism. [35][36][37][38][39] Catalase is one of the major enzymes that detoxifies hydrogen peroxide in the body, functioning as a powerful catalytic anti-oxidant. Catalase converts hydrogen peroxide to water and oxygen.…”

Section: Does Hydrogen Peroxide Functionmentioning

confidence: 99%

Hydrogen peroxide fuels aging, inflammation, cancer metabolism and metastasis

et al. 2011

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“…17 Studies have demonstrated that breast cancers show high levels of oxidative stress as verified by the detection of oxidative DNA adducts in breast cancer tissue 31 or a significant raise in oxidative stress markers in the plasma from breast cancer patients. 32 Moreover, the use of chemotherapy increases oxidative stress 33 FAC chemotherapy and radiotherapy promote further oxidative shift, which potentiate already existing chronic oxidative stress linked to breast cancer. 33 Whereas the protective action of GLN in cancer bearing experimental animals has been demonstrated, 16 one would expect a similar effect in humans.…”

Section: Resultsmentioning

confidence: 99%

“…32 Moreover, the use of chemotherapy increases oxidative stress 33 FAC chemotherapy and radiotherapy promote further oxidative shift, which potentiate already existing chronic oxidative stress linked to breast cancer. 33 Whereas the protective action of GLN in cancer bearing experimental animals has been demonstrated, 16 one would expect a similar effect in humans. It is questioned why GSH levels did not increase in this study.…”

Section: Resultsmentioning

confidence: 99%

Oxidative stress parameters in women with breast cancer undergoing neoadjuvant chemotherapy and treated with nutraceutical doses of oral glutamine

Farias¹,

Furtado²,

Guimarães³

et al. 2011

Acta Cir. Bras.

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PURPOSE: To evaluate the effects of oral administration of GLN on the oxidative stress in women with breast cancer undergoing neoadjuvant FAC chemotherapy (5 fluouracil 500 mg/m²+Doxorubicin 50 mg/m²+Cyclophosphamide 500 mg/m² body surface area). METHODS: Twenty women (mean age: 51.7 years) with breast ductal carcinomas classified as T3 or T4 were included in the study, regardless of pre or post menopause status. Sachets containing glutamine 15g ("A") or milk protein 15g ("B") were prepared by a registered pharmacist. Allocation of patients was made by software program. Patients who received sachets labeled "A" were included in G1 group. The remaining patients, treated with the preparation labeled "B", were included in group G2. Sachets contents were blended in 150 ml of drinking water, and were given daily to each patient during the entire course of neoadjuvant chemotherapy. Peripheral blood samples were collected in the first day of each of the three cycles of chemotherapy before drug infusion. Tumor and normal breast samples were collected at the end of Patey´s surgical procedure. Samples were analysed for GSH and TBARS contents. RESULTS: TBARS and GSH values were not different in breast healthy and tumor tissues nor blood when comparing control (G-2) and glutamine-treated (G-1) patients. Also, no significant differences were found in TBARS and GSH levels comparing different timepoints within the same group. CONCLUSION: Oral GLN (15g/kg/day) offers no protection against systemic or local oxidative stress in women with breast Ca undergoing neoadjuvant chemotherapy (FAC).

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Antioxidant status and lipid peroxidation in the blood of breast cancer patients of different ages after chemotherapy with 5-fluorouracil, doxorubicin and cyclophosphamide

Cited by 82 publications

References 50 publications

Cancer cells metabolically "fertilize" the tumor microenvironment with hydrogen peroxide, driving the Warburg effect

Cancer cells metabolically "fertilize" the tumor microenvironment with hydrogen peroxide, driving the Warburg effect

Hydrogen peroxide fuels aging, inflammation, cancer metabolism and metastasis

Oxidative stress parameters in women with breast cancer undergoing neoadjuvant chemotherapy and treated with nutraceutical doses of oral glutamine

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