Antioxidant role of mulberry (Morus indica L. cv. Anantha) leaves in streptozotocin-diabetic rats

Andallu, B.; Nallanchakravarthula, Varadacharyulu

doi:10.1016/s0009-8981(03)00322-x

Cited by 179 publications

(121 citation statements)

References 34 publications

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“…In addition, significant increase revealed in food efficiency ratio (FER) for all groups (diabetic rats) fed on white and black mulberry as well as its mixture comparing to the diabetic control group. Our findings are, in fact, in a good agreement with that for Andallu and Varadacharyulu [47]. Another theory stated that alloxan decreases body weight due to depressed synthesis of DNA and RNA in the diabetic animals [48].…”

Section: Changes In Body Weight and Food Consumptionsupporting

confidence: 92%

Hypoglycemic effect of white (Morus alba L.) and black (Morus nigra L.) mulberry fruits in diabetic rat

et al. 2014

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KEYWORDSThe aim of the present study was to investigate the hypoglycemic effect of white (Morus alba L.) and black (Morus nigra L.) mulberry fruits either used individually or in a combination on alloxan diabetic rats. These fruits are reported to be rich in antioxidants, flavonoids and phenolics that can potentially fight against diabetes mellitus. Male albino rats were divided into 5 groups: normal control, alloxan-diabetic control, diabetic rats treated with white mulberry fruit powder at 5% in the diet, diabetic rats treated with black mulberry fruit powder at 5% in the diet and diabetic rats treated with mixture of white and black mulberry fruits powder at 5% in the diet. After 4 weeks of treatment, blood glucose level, liver and kidney enzymes activity, lipid profile, lipid peroxidation and histopathological studies on liver, kidney and pancreas were evaluated. The mixture of white and black mulberry fruits showed the most significant (p < 0.05) improvement in feed efficiency ratio with increasing body weight gain, as well as decrease in blood glucose level and liver-kidney dysfunction when compared with diabetic control rats. Significant decrease in serum cholesterol, triglycerides and low density lipoprotein cholesterol (LDLc) as well as significant increase in high density lipoprotein cholesterol (HDLc) in diabetic rats was observed with all treatments. Moreover, mulberry fruits administration caused significant inhibition in lipid peroxidation and α-amylase activity. In addition, the beneficial effect of all treatments was further confirmed with histopathological examination of liver, kidney and pancreas. This study reveals hypoglycemic and hypolipidemic effects of white and black mulberry fruits either used individually or in combination as a dietary supplement in alloxan diabetic rats. Alloxan Antidiabetic Hypoglycemic Morus alba fruits Morus nigra fruits Lipid peroxidation

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Section: Changes In Body Weight and Food Consumptionsupporting

confidence: 92%

Hypoglycemic effect of white (Morus alba L.) and black (Morus nigra L.) mulberry fruits in diabetic rat

et al. 2014

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“…GPx and GST work together with glutathione in the decomposition of H 2 O 2 and other organic hydroperoxides to non-toxic products at the expense of the GSH (Bruce, Freeman & James 1982). The decreased activity of GST observed in diabetic state may be because of the inactivation caused by ROS (Andallu & Varadacharyulu 2003).…”

Section: Discussionmentioning

confidence: 99%

Antidiabetic and anti-oxidant activities of the methanol leaf extract of <i>Vernonia amygdalina</i> in alloxan-induced diabetes in Wistar rats

Adeoye

Oyagbemi

Adedapo

et al. 2017

JOMPED

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The methanolic leaf extract of Vernonia amygdalina (MLVA) was assessed to evaluate its antidiabetic potential in rats. Diabetes was induced in male Wistar rats by the administration of alloxan monohydrate at 100 mg/kg of body weight. After 48 h, rats with fasting blood glucose levels of 200 mg/dL and above were considered diabetic and used for the study. The experimental animals were grouped into five groups (A–E) of 10 animals each. Group A rats were non-diabetic normal control, Group B consisted of diabetic control rats that received no treatment, groups C, D and E rats were diabetic rats but treated with glibenclamide, 200 and 400 mg/kg doses of MLVA respectively. Blood samples were collected at days 14 and 28 after induction for haematological and serum biochemical indices such as triglycerides, LDL, cholesterols etc. The intestine was collected and intestinal homogenate was prepared for the antioxidant studies. The extract at 200 mg/kg and 400 mg/kg doses significantly (p < 0.05) reduced blood glucose levels in extract-treated diabetic rats and also significantly increased weight gain in these rats. Most haematological parameters in treated rats experienced, while platelets and neutrophils were decreased. Biochemical indices measured were reduced in MLVA-treated groups compared with diabetic control. Treatment with MLVA also produced significant (p < 0.05) decrease in markers of oxidative stress but increased levels of enzymic and non-enzymic antioxidant markers in intestinal homogenates of treated groups compared with diabetic control. This study showed that V. amygdalina has antihyperglycaemic and in vivo antioxidant effects.

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“…Kidneys taken metabolism may be responsible [25]. Reduction in body weight in the STZ diabetic rats in comparison to normal rats indicate excessive break down of tissue proteins [26]. O. gratissimum in this study caused more weight reduction in comparison to diabetic control.…”

Section: Results Of Kidney Histopathologymentioning

confidence: 54%

Ocimum Gratissimum Linn Worsens Streptozotocin-Induced Nephrotoxicity in Diabetic Wistar Rats

2012

Maced J Med Sci

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Effects of ethanolic extract of Ocimum gratissimum leaves (O. gratissimum) on the kidneys in Streptozotocin-induced diabetic rats were studied. Thirty-six adult rats were assigned into six groups (A, B, C, D, E and F) of six rats each. Diabetes was induced with a single intraperitoneal injection of Streptozotocin. Group A (non diabetic control) and F (diabetic control) received normal saline orally, group B received a Metformin at 25 mg/kg while groups C, D and E had O. gratissimum at 400, 600 and 800 mg/kg. Body weight and fasting blood glucose levels were monitored weekly; blood levels of Creatinine (Cr) and Urea (U) were measured on day twenty eight. Animals were sacrificed and kidney sections processed for histological study. Statistical analysis was carried out using a one way ANOVA followed by a post-hoc test. Results showed significant reduction in body weight and blood glucose levels in the groups that received either metformin or O.gratissimum as well as dose dependent increase in blood urea and creatinine levels, histopathology revealed varying degrees of renal injury. The study concluded that O. gratissimum worsens diabetes induced renal injury.

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Antioxidant role of mulberry (Morus indica L. cv. Anantha) leaves in streptozotocin-diabetic rats

Cited by 179 publications

References 34 publications

Hypoglycemic effect of white (Morus alba L.) and black (Morus nigra L.) mulberry fruits in diabetic rat

Hypoglycemic effect of white (Morus alba L.) and black (Morus nigra L.) mulberry fruits in diabetic rat

Antidiabetic and anti-oxidant activities of the methanol leaf extract of <i>Vernonia amygdalina</i> in alloxan-induced diabetes in Wistar rats

Ocimum Gratissimum Linn Worsens Streptozotocin-Induced Nephrotoxicity in Diabetic Wistar Rats

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