Antioxidant properties of N-acetylcysteine: their relevance in relation to chronic obstructive pulmonary disease

Dekhuijzen, P.N.R.

doi:10.1183/09031936.04.00016804

Cited by 269 publications

(204 citation statements)

References 87 publications

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“…It is the acetylated derivative of the aminoacid L-cysteine and a precursor for reduced glutathione (GSH) [215,216]. It appears to have direct antioxidant action since its free thiol can interact with the electrophilic groups of ROS [215].…”

Section: Antioxidantsmentioning

confidence: 99%

Lipid Peroxidation and Antioxidants in Arterial Hypertension

Sousa¹,

Afonso²,

Albino‐Teixeira³

et al. 2012

Lipid Peroxidation

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Section: Antioxidantsmentioning

confidence: 99%

Lipid Peroxidation and Antioxidants in Arterial Hypertension

Sousa¹,

Afonso²,

Albino‐Teixeira³

et al. 2012

Lipid Peroxidation

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“…Once administered orally or by injection, it can be rapidly absorbed and transformed into aminothiopropionic acid by deacetylation [14] . By generating aminothiopropionic acid, the substrate of the endocellular antioxidant reduced glutathione hormone (GSH), NAC eventually complements intracellular GSH levels, elevates the ratio of GSH/GSSG, and promotes the antioxidative effects of GSH.…”

Section: Introductionmentioning

confidence: 99%

NAC is associated with additional alleviation of lung injury induced by invasive pulmonary aspergillosis in a neutropenic model

Jian

et al. 2009

Acta Pharmacol Sin

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Aim: Neutropenic individuals are at high risk for invasive pulmonary aspergillosis (IPA), a life-threatening infection. To evaluate the therapeutic potential of antioxidants, IPA was induced in neutropenic mice and the effect of N-acetyl-l-cysteine (NAC) on oxidative stress levels and lung injury was analyzed. Methods: Mice were pretreated with three daily intraperitoneal injections of 150 mg/kg cyclophosphamide, followed by intratracheal inoculation with 4.5×10 6 conidia of Aspergillus fumigatus. The infected mice were then randomly assigned to an amphotericin B (AMB) group, an AMB plus NAC group, or an untreated control (C) group. In each group, the duration of treatment was 24, 48, or 72 h, and activities such as appearance, feeding, and dermal temperature were observed throughout the experiment. Sera and lung tissues were collected and analyzed by quantitative enzyme-linked immunosorbent assay (ELISA) for total protein, superoxide dismutase (SOD), malondialdehyde (MDA), tumor necrosis factor-α (TNF-α), and interleukin-10 (IL-10) levels. The wet/dry weight ratio of the lung was also calculated and lung sections were stained with hematoxylin-eosin for pathological examination and with methenamine silver stain for fungus detection. Results: Compared with the mice untreated with NAC, mice in the AMB plus NAC group had increased SOD and reduced MDA levels both systemically and locally at 24, 48, and 72 h after inoculation with conidia. NAC treatment also decreased the pulmonary protein content at 48 and 72 h and the lung wet/dry weight ratio at 24 and 48 h. Additionally, NAC enhanced pulmonary production of TNF-α and IL-10 at 24 h and 48 h. Conclusion: In combination with antifungal therapy, NAC treatment can alleviate oxidative stress and lung injury associated with IPA in neutropenic mice.

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“…Mucus hypersecretion is not an innocent disorder. However, despite these observations, until now few studies have focused on the effects of mucolytic drugs in patients with COPD, even though some of these mucolytic drugs also appear to have antioxidant properties (Dekhuijzen, 2004;Rahman et al, 1997;Rahman & Kilty 2006;Decramer & Janssens, 2010).…”

Section: Chronic Obstructive Pulmonary Disease (Copd)mentioning

confidence: 99%