Novel Concept in Pulmonary Delivery

Carafa, Maria; Marianecci, Carlotta; Paolino, Donatella; Marzio, Luisa Di; Celia, Christian; Fresta, Massimo; Alhaique, Franco

doi:10.5772/28780

Cited by 2 publications

(2 citation statements)

References 118 publications

(104 reference statements)

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“…Aerosol drug delivery has been a technique used for the treatment of a variety of diseases and recently for experimental antineoplastic therapies [11]. This route increases the bioavailability and decreases the time of action because the doses decrease the risk of side effects, and the drug reaches the lung tissue without the metabolic changes that occur in the liver [19,20]. These benefits have been observed in asthma, COPD, and some lung infections [21,22].…”

Section: Introductionmentioning

confidence: 99%

The Effect of Vanadium Inhalation on the Tumor Progression of Urethane-Induced Lung Adenomas in a Mice Model

2021

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Lung cancer has the highest death rates. Aerosol drug delivery has been used for other lung diseases. The use of inhaled vanadium (V) as an option for lung cancer treatment is explored. Four groups of mice were studied: (1) Saline inhalation alone, (2) Single intraperitoneal (i.p.) dose of urethane, (3) V nebulization twice a week (Wk) for 8 Wk, and (4) A single dose of urethane and V nebulization for 8 Wk. Mice were sacrificed at the end of the experiment. Number and size of tumors, PCNA (proliferating cell nuclear antigen) and TUNEL (terminal deoxynucleotidyl tranferase dUTP nick-end labeling) immunohistochemistry were evaluated and compared within groups. Results: The size and number of tumors decreased in mice exposed to V-urethane and the TUNEL increased in this group; differences in the PCNA were not observed. Conclusions: Aerosol V delivery increased apoptosis and possibly the growth arrest of the tumors with no respiratory clinical changes in the mice.

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Section: Introductionmentioning

confidence: 99%

The Effect of Vanadium Inhalation on the Tumor Progression of Urethane-Induced Lung Adenomas in a Mice Model

2021

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“…Bronchial secretion is a kind of non‐Newtonian fluid that mainly consists of water and macromolecular constituents . The most specific part of bronchial secretion is mucus which is approximately 30 μm thick .…”

Section: Introductionmentioning

confidence: 99%

ANSYS‐MATLAB co‐simulation of mucus flow distribution and clearance effectiveness of a new simulated cough device

Ren

Shi

Cai

et al. 2018

Numer Methods Biomed Eng

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Coughing is an irritable reaction that protects the respiratory system from infection and improves mucus clearance. However, for the patients who cannot cough autonomously, an assisted cough device is essential for mucus clearance. Considering the low efficiency of current assisted cough devices, a new simulated cough device based on the pneumatic system is proposed in this paper. Given the uncertainty of airflow rates necessary to clear mucus from airways, the computational fluid dynamics Eulerian wall film model and cough efficiency (CE) were used in this study to simulate the cough process and evaluate cough effectiveness. The Ansys-Matlab co-simulation model was set up and verified through experimental studies using Newtonian fluids. Next, model simulations were performed using non-Newtonian fluids, and peak cough flow (PCF) and PCF duration time were analyzed to determine their influence on mucus clearance. CE growth rate (λ) was calculated to reflect the CE variation trend. From the numerical simulation results, we find that CE rises as PCF increases while the growth rate trends to slow as PCF increases; when PCF changes from 60 to 360 L/min, CE changes from 3.2% to 51.5% which is approximately 16 times the initial value. Meanwhile, keeping a long PCF duration time could greatly improve CE under the same cough expired volume and PCF. The results indicated that increasing the PCF and PCF duration time can improve the efficiency of mucus clearance. This paper provides a new approach and a research direction for control strategy in simulated cough devices for airway mucus clearance.

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Novel Concept in Pulmonary Delivery

Cited by 2 publications

References 118 publications

The Effect of Vanadium Inhalation on the Tumor Progression of Urethane-Induced Lung Adenomas in a Mice Model

The Effect of Vanadium Inhalation on the Tumor Progression of Urethane-Induced Lung Adenomas in a Mice Model

ANSYS‐MATLAB co‐simulation of mucus flow distribution and clearance effectiveness of a new simulated cough device

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